Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
Аутори
Cumbo, MarijaTomić, Branko
Dunjić Manevski, Sofija
Jovanović, Tamara
Gvozdenov, Maja
Pruner, Iva
Aralica, Gorana
Kapitanović, Sanja
Cacev, Tamara
Đorđević, Valentina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end g...ene variants may play a role in colorectal cancer.
Кључне речи:
tumor / prothrombin / normal adjacent tissue / Colon adenocarcinoma / 3'end gene variantsИзвор:
Anticancer Research, 2019, 39, 11, 6067-6071Издавач:
- Int Inst Anticancer Research, Athens
Финансирање / пројекти:
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
- Republic of Serbia
- Republic of Croatia
DOI: 10.21873/anticanres.13814
ISSN: 0250-7005
PubMed: 31704834
WoS: 000496129100026
Scopus: 2-s2.0-85074729699
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Cumbo, Marija AU - Tomić, Branko AU - Dunjić Manevski, Sofija AU - Jovanović, Tamara AU - Gvozdenov, Maja AU - Pruner, Iva AU - Aralica, Gorana AU - Kapitanović, Sanja AU - Cacev, Tamara AU - Đorđević, Valentina PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1219 AB - Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer. PB - Int Inst Anticancer Research, Athens T2 - Anticancer Research T1 - Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma EP - 6071 IS - 11 SP - 6067 VL - 39 DO - 10.21873/anticanres.13814 ER -
@article{ author = "Cumbo, Marija and Tomić, Branko and Dunjić Manevski, Sofija and Jovanović, Tamara and Gvozdenov, Maja and Pruner, Iva and Aralica, Gorana and Kapitanović, Sanja and Cacev, Tamara and Đorđević, Valentina", year = "2019", abstract = "Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer.", publisher = "Int Inst Anticancer Research, Athens", journal = "Anticancer Research", title = "Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma", pages = "6071-6067", number = "11", volume = "39", doi = "10.21873/anticanres.13814" }
Cumbo, M., Tomić, B., Dunjić Manevski, S., Jovanović, T., Gvozdenov, M., Pruner, I., Aralica, G., Kapitanović, S., Cacev, T.,& Đorđević, V.. (2019). Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma. in Anticancer Research Int Inst Anticancer Research, Athens., 39(11), 6067-6071. https://doi.org/10.21873/anticanres.13814
Cumbo M, Tomić B, Dunjić Manevski S, Jovanović T, Gvozdenov M, Pruner I, Aralica G, Kapitanović S, Cacev T, Đorđević V. Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma. in Anticancer Research. 2019;39(11):6067-6071. doi:10.21873/anticanres.13814 .
Cumbo, Marija, Tomić, Branko, Dunjić Manevski, Sofija, Jovanović, Tamara, Gvozdenov, Maja, Pruner, Iva, Aralica, Gorana, Kapitanović, Sanja, Cacev, Tamara, Đorđević, Valentina, "Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma" in Anticancer Research, 39, no. 11 (2019):6067-6071, https://doi.org/10.21873/anticanres.13814 . .