Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies
Апстракт
Ankrd2 (ankyrin repeats containing domain 2) or Arpp (ankyrin repeat, PEST sequence, and proline-rich region) is a member of the muscle ankyrin repeat protein family. Ankrd2 is mostly expressed in skeletal muscle, where it plays an intriguing role in the transcriptional response to stress induced by mechanical stimulation as well as by cellular reactive oxygen species. Our studies in myoblasts from Emery-Dreifuss muscular dystrophy 2, a LMNA-linked disease affecting skeletal and cardiac muscles, demonstrated that Ankrd2 is a lamin A-binding protein and that mutated lamins found in Emery-Dreifuss muscular dystrophy change the dynamics of Ankrd2 nuclear import, thus affecting oxidative stress response. In this review, besides describing the latest advances related to Ankrd2 studies, including novel discoveries on Ankrd2 isoform-specific functions, we report the main findings on the relationship of Ankrd2 with A-type lamins and discuss known and potential mechanisms involving defective An...krd2-lamin A interplay in the pathogenesis of muscular laminopathies.
Извор:
Oxidative Medicine and Cellular Longevity, 2019, 2019Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- "Associazione Italiana Distrofia Muscolare di Emery-Dreifuss" (AIDMED) onlus
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
- Associazione Alessandra Proietti Onlus
- MIUR [PRIN 2015FBNB5Y]
- Italian Network for Laminopathies
DOI: 10.1155/2019/7318796
ISSN: 1942-0900
PubMed: 31428229
WoS: 000478926800001
Scopus: 2-s2.0-85071416822
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Cenni, Vittoria AU - Kojić, Snežana AU - Capanni, Cristina AU - Faulkner, Georgine AU - Lattanzi, Giovanna PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1282 AB - Ankrd2 (ankyrin repeats containing domain 2) or Arpp (ankyrin repeat, PEST sequence, and proline-rich region) is a member of the muscle ankyrin repeat protein family. Ankrd2 is mostly expressed in skeletal muscle, where it plays an intriguing role in the transcriptional response to stress induced by mechanical stimulation as well as by cellular reactive oxygen species. Our studies in myoblasts from Emery-Dreifuss muscular dystrophy 2, a LMNA-linked disease affecting skeletal and cardiac muscles, demonstrated that Ankrd2 is a lamin A-binding protein and that mutated lamins found in Emery-Dreifuss muscular dystrophy change the dynamics of Ankrd2 nuclear import, thus affecting oxidative stress response. In this review, besides describing the latest advances related to Ankrd2 studies, including novel discoveries on Ankrd2 isoform-specific functions, we report the main findings on the relationship of Ankrd2 with A-type lamins and discuss known and potential mechanisms involving defective Ankrd2-lamin A interplay in the pathogenesis of muscular laminopathies. PB - Hindawi Ltd, London T2 - Oxidative Medicine and Cellular Longevity T1 - Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies VL - 2019 DO - 10.1155/2019/7318796 ER -
@article{ author = "Cenni, Vittoria and Kojić, Snežana and Capanni, Cristina and Faulkner, Georgine and Lattanzi, Giovanna", year = "2019", abstract = "Ankrd2 (ankyrin repeats containing domain 2) or Arpp (ankyrin repeat, PEST sequence, and proline-rich region) is a member of the muscle ankyrin repeat protein family. Ankrd2 is mostly expressed in skeletal muscle, where it plays an intriguing role in the transcriptional response to stress induced by mechanical stimulation as well as by cellular reactive oxygen species. Our studies in myoblasts from Emery-Dreifuss muscular dystrophy 2, a LMNA-linked disease affecting skeletal and cardiac muscles, demonstrated that Ankrd2 is a lamin A-binding protein and that mutated lamins found in Emery-Dreifuss muscular dystrophy change the dynamics of Ankrd2 nuclear import, thus affecting oxidative stress response. In this review, besides describing the latest advances related to Ankrd2 studies, including novel discoveries on Ankrd2 isoform-specific functions, we report the main findings on the relationship of Ankrd2 with A-type lamins and discuss known and potential mechanisms involving defective Ankrd2-lamin A interplay in the pathogenesis of muscular laminopathies.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine and Cellular Longevity", title = "Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies", volume = "2019", doi = "10.1155/2019/7318796" }
Cenni, V., Kojić, S., Capanni, C., Faulkner, G.,& Lattanzi, G.. (2019). Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. in Oxidative Medicine and Cellular Longevity Hindawi Ltd, London., 2019. https://doi.org/10.1155/2019/7318796
Cenni V, Kojić S, Capanni C, Faulkner G, Lattanzi G. Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. in Oxidative Medicine and Cellular Longevity. 2019;2019. doi:10.1155/2019/7318796 .
Cenni, Vittoria, Kojić, Snežana, Capanni, Cristina, Faulkner, Georgine, Lattanzi, Giovanna, "Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies" in Oxidative Medicine and Cellular Longevity, 2019 (2019), https://doi.org/10.1155/2019/7318796 . .