FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle
2000
Аутори
Faulkner, GPallavicini, A
Comelli, A
Salamon, M
Bortoletto, G
Ievolella, C
Trevisan, S
Kojić, Snežana
Dalla Vecchia, F
Laveder, P
Valle, G
Lanfranchi, G
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We report the identification and characterization of a novel 32-kDa protein expressed in skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds to three other Z-disc proteins; therefore, we have-named it FATZ, gamma -filamin/ABP-L, alpha -actinin and telethonin binding protein of the Z-disc. From yeast two-hybrid experiments we are able to show that the SR3-SR4 domains of alpha -actinin 2 are required to bind the COOH-terminal region of the FATZ as does gamma -filamin/ABP-L, Furthermore, by using a glutathione S-transferase overlay assay we find that FATZ also binds telethonin. The level of FATZ protein in muscle cells increases during differentiation, being clearly detectable before the onset of myosin, Although FATZ has no known interaction domains, it would appear to be involved in a complex network of interactions with other Z-band components. On the basis of the information known about its binding partners, we could envisage a central role for... FATZ in the: myofibrillogenesis, After screening our muscle expressed sequence tag data base and the public expressed sequence tag data bases, we were able to assemble two other muscle transcripts that show a high level of identity with FATZ in two different domains. Therefore, FATZ may be the first member of a small family of novel muscle proteins.
Извор:
Journal of Biological Chemistry, 2000, 275, 52, 41234-41242Издавач:
- Amer Soc Biochemistry Molecular Biology Inc, Rockville
Финансирање / пројекти:
- Telethon [B.57, 1023] Funding Source: Medline
DOI: 10.1074/jbc.M007493200
ISSN: 0021-9258
PubMed: 10984498
WoS: 000166114600077
Scopus: 2-s2.0-0034731460
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Faulkner, G AU - Pallavicini, A AU - Comelli, A AU - Salamon, M AU - Bortoletto, G AU - Ievolella, C AU - Trevisan, S AU - Kojić, Snežana AU - Dalla Vecchia, F AU - Laveder, P AU - Valle, G AU - Lanfranchi, G PY - 2000 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/142 AB - We report the identification and characterization of a novel 32-kDa protein expressed in skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds to three other Z-disc proteins; therefore, we have-named it FATZ, gamma -filamin/ABP-L, alpha -actinin and telethonin binding protein of the Z-disc. From yeast two-hybrid experiments we are able to show that the SR3-SR4 domains of alpha -actinin 2 are required to bind the COOH-terminal region of the FATZ as does gamma -filamin/ABP-L, Furthermore, by using a glutathione S-transferase overlay assay we find that FATZ also binds telethonin. The level of FATZ protein in muscle cells increases during differentiation, being clearly detectable before the onset of myosin, Although FATZ has no known interaction domains, it would appear to be involved in a complex network of interactions with other Z-band components. On the basis of the information known about its binding partners, we could envisage a central role for FATZ in the: myofibrillogenesis, After screening our muscle expressed sequence tag data base and the public expressed sequence tag data bases, we were able to assemble two other muscle transcripts that show a high level of identity with FATZ in two different domains. Therefore, FATZ may be the first member of a small family of novel muscle proteins. PB - Amer Soc Biochemistry Molecular Biology Inc, Rockville T2 - Journal of Biological Chemistry T1 - FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle EP - 41242 IS - 52 SP - 41234 VL - 275 DO - 10.1074/jbc.M007493200 ER -
@article{ author = "Faulkner, G and Pallavicini, A and Comelli, A and Salamon, M and Bortoletto, G and Ievolella, C and Trevisan, S and Kojić, Snežana and Dalla Vecchia, F and Laveder, P and Valle, G and Lanfranchi, G", year = "2000", abstract = "We report the identification and characterization of a novel 32-kDa protein expressed in skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds to three other Z-disc proteins; therefore, we have-named it FATZ, gamma -filamin/ABP-L, alpha -actinin and telethonin binding protein of the Z-disc. From yeast two-hybrid experiments we are able to show that the SR3-SR4 domains of alpha -actinin 2 are required to bind the COOH-terminal region of the FATZ as does gamma -filamin/ABP-L, Furthermore, by using a glutathione S-transferase overlay assay we find that FATZ also binds telethonin. The level of FATZ protein in muscle cells increases during differentiation, being clearly detectable before the onset of myosin, Although FATZ has no known interaction domains, it would appear to be involved in a complex network of interactions with other Z-band components. On the basis of the information known about its binding partners, we could envisage a central role for FATZ in the: myofibrillogenesis, After screening our muscle expressed sequence tag data base and the public expressed sequence tag data bases, we were able to assemble two other muscle transcripts that show a high level of identity with FATZ in two different domains. Therefore, FATZ may be the first member of a small family of novel muscle proteins.", publisher = "Amer Soc Biochemistry Molecular Biology Inc, Rockville", journal = "Journal of Biological Chemistry", title = "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle", pages = "41242-41234", number = "52", volume = "275", doi = "10.1074/jbc.M007493200" }
Faulkner, G., Pallavicini, A., Comelli, A., Salamon, M., Bortoletto, G., Ievolella, C., Trevisan, S., Kojić, S., Dalla Vecchia, F., Laveder, P., Valle, G.,& Lanfranchi, G.. (2000). FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle. in Journal of Biological Chemistry Amer Soc Biochemistry Molecular Biology Inc, Rockville., 275(52), 41234-41242. https://doi.org/10.1074/jbc.M007493200
Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojić S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G. FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle. in Journal of Biological Chemistry. 2000;275(52):41234-41242. doi:10.1074/jbc.M007493200 .
Faulkner, G, Pallavicini, A, Comelli, A, Salamon, M, Bortoletto, G, Ievolella, C, Trevisan, S, Kojić, Snežana, Dalla Vecchia, F, Laveder, P, Valle, G, Lanfranchi, G, "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle" in Journal of Biological Chemistry, 275, no. 52 (2000):41234-41242, https://doi.org/10.1074/jbc.M007493200 . .