Biomarkers of Uremic Cardiotoxicity
2021
Аутори
Stopić, BojanDragičević, Sandra
Medić-Brkić, Branislava
Nikolić, Aleksandra
Stojanović, Marko
Budisavljević, Sreten
Dimković, Nada
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a-4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in re...gards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients.
Кључне речи:
oxidative stress / microRNAs / inflammation / cardiovascular event / biomarkers / acute renal injuryИзвор:
Toxins, 2021, 13, 9Издавач:
- MDPI, Basel
DOI: 10.3390/toxins13090639
ISSN: 2072-6651
PubMed: 34564643
WoS: 000700149700001
Scopus: 2-s2.0-85115129191
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stopić, Bojan AU - Dragičević, Sandra AU - Medić-Brkić, Branislava AU - Nikolić, Aleksandra AU - Stojanović, Marko AU - Budisavljević, Sreten AU - Dimković, Nada PY - 2021 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1463 AB - Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a-4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients. PB - MDPI, Basel T2 - Toxins T1 - Biomarkers of Uremic Cardiotoxicity IS - 9 VL - 13 DO - 10.3390/toxins13090639 ER -
@article{ author = "Stopić, Bojan and Dragičević, Sandra and Medić-Brkić, Branislava and Nikolić, Aleksandra and Stojanović, Marko and Budisavljević, Sreten and Dimković, Nada", year = "2021", abstract = "Cardiovascular (CV) morbidity and mortality increase along with the progression of chronic kidney disease (CKD). The potential novel biomarkers of cardiotoxicity have been tested with the aim of the early detection of patients at high CV risk, and among them are markers of inflammation, oxidative stress, acute renal injury, and microRNAs. The study analyzed biomarkers in non-dialysis-dependent (NDD; stage 3a-4 CKD) and dialysis-dependent (DD) CKD patients. The prospective cohort study included 87 patients who were followed for 18 months, during which period newly occurred CV events were recorded. Cox regression analysis confirmed serum albumin, urea, interventricular septum thickness diameter (IVST), the use of calcium antagonist, and erythropoiesis-stimulating agent to be significant predictors of CV outcome. No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. Serum albumin, urea, IVST, and the use of calcium antagonist and erythropoiesis-stimulating agents were confirmed to be factors associated with CV events in CKD patients. Apart from traditional risk factors, new research is needed to define novel and reliable biomarkers of cardiotoxicity in CKD patients.", publisher = "MDPI, Basel", journal = "Toxins", title = "Biomarkers of Uremic Cardiotoxicity", number = "9", volume = "13", doi = "10.3390/toxins13090639" }
Stopić, B., Dragičević, S., Medić-Brkić, B., Nikolić, A., Stojanović, M., Budisavljević, S.,& Dimković, N.. (2021). Biomarkers of Uremic Cardiotoxicity. in Toxins MDPI, Basel., 13(9). https://doi.org/10.3390/toxins13090639
Stopić B, Dragičević S, Medić-Brkić B, Nikolić A, Stojanović M, Budisavljević S, Dimković N. Biomarkers of Uremic Cardiotoxicity. in Toxins. 2021;13(9). doi:10.3390/toxins13090639 .
Stopić, Bojan, Dragičević, Sandra, Medić-Brkić, Branislava, Nikolić, Aleksandra, Stojanović, Marko, Budisavljević, Sreten, Dimković, Nada, "Biomarkers of Uremic Cardiotoxicity" in Toxins, 13, no. 9 (2021), https://doi.org/10.3390/toxins13090639 . .