Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
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2022
Authors
Marković, Sanja B.Maciejewska, Natalia
Olszewski, Mateusz
Visnjevac, Aleksandar
Puerta, Adrian
Padron, Jose M.
Novaković, Irena
Kojić, Snežana
Fernandes, Henrique S.
Ramotowska, Sandra
Chylewska, Agnieszka
Makowski, Mariusz
Todorović, Tamara R.
Filipović, Nenad R.
Article (Published version)
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Show full item recordAbstract
The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell ...growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carci-noma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.
Keywords:
Hydrazonyl-thiazoles / DNA interactions / Cd complexes / Autophagy / ApoptosisSource:
European Journal of Medicinal Chemistry, 2022, 238Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Funding / projects:
- Spanish Government [PGC2018-094503-B-C22]
- Canary Islands Government [ProID2020010101]
- Canary Islands ACIISI [TESIS2020010055]
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200116 (University of Belgrade, Faculty of Agriculture) (RS-MESTD-inst-2020-200116)
DOI: 10.1016/j.ejmech.2022.114449
ISSN: 0223-5234
PubMed: 35580425
WoS: 000810149900002
Scopus: 2-s2.0-85130369502
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Marković, Sanja B. AU - Maciejewska, Natalia AU - Olszewski, Mateusz AU - Visnjevac, Aleksandar AU - Puerta, Adrian AU - Padron, Jose M. AU - Novaković, Irena AU - Kojić, Snežana AU - Fernandes, Henrique S. AU - Ramotowska, Sandra AU - Chylewska, Agnieszka AU - Makowski, Mariusz AU - Todorović, Tamara R. AU - Filipović, Nenad R. PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1551 AB - The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carci-noma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters VL - 238 DO - 10.1016/j.ejmech.2022.114449 ER -
@article{ author = "Marković, Sanja B. and Maciejewska, Natalia and Olszewski, Mateusz and Visnjevac, Aleksandar and Puerta, Adrian and Padron, Jose M. and Novaković, Irena and Kojić, Snežana and Fernandes, Henrique S. and Ramotowska, Sandra and Chylewska, Agnieszka and Makowski, Mariusz and Todorović, Tamara R. and Filipović, Nenad R.", year = "2022", abstract = "The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carci-noma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters", volume = "238", doi = "10.1016/j.ejmech.2022.114449" }
Marković, S. B., Maciejewska, N., Olszewski, M., Visnjevac, A., Puerta, A., Padron, J. M., Novaković, I., Kojić, S., Fernandes, H. S., Ramotowska, S., Chylewska, A., Makowski, M., Todorović, T. R.,& Filipović, N. R.. (2022). Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 238. https://doi.org/10.1016/j.ejmech.2022.114449
Marković SB, Maciejewska N, Olszewski M, Visnjevac A, Puerta A, Padron JM, Novaković I, Kojić S, Fernandes HS, Ramotowska S, Chylewska A, Makowski M, Todorović TR, Filipović NR. Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry. 2022;238. doi:10.1016/j.ejmech.2022.114449 .
Marković, Sanja B., Maciejewska, Natalia, Olszewski, Mateusz, Visnjevac, Aleksandar, Puerta, Adrian, Padron, Jose M., Novaković, Irena, Kojić, Snežana, Fernandes, Henrique S., Ramotowska, Sandra, Chylewska, Agnieszka, Makowski, Mariusz, Todorović, Tamara R., Filipović, Nenad R., "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters" in European Journal of Medicinal Chemistry, 238 (2022), https://doi.org/10.1016/j.ejmech.2022.114449 . .