The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation
Authors
Dunjić, SofijaCumbo, Marija
Gvozdenov, Maja
Taxiarchis, Apostolos
Tomić, Branko
Antović, Jovan
Đorđević, Valentina
Conference object (Published version)
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Prothrombin Belgrade mutation is a result of the c.1787G>T
mutation in the prothrombin gene, which leads to the substitution of
Arg596 by Gln. This mutation is located in the antithrombin binding site
and leads to the impaired inactivation of thrombin by antithrombin and
antithrombin resistance, resulting in a thrombotic phenotype. Previous
studies have shown the complex mechanism of this mutation, manifested with higher endogenous thrombin potential, lower prothrombin
activity with normal prothrombin levels in carriers’ plasma.
Source:
Research and Practice in Thrombosis and Haemostasis, 2020, 4, 1, 1117-1117Note:
- PB2232
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Dunjić, Sofija AU - Cumbo, Marija AU - Gvozdenov, Maja AU - Taxiarchis, Apostolos AU - Tomić, Branko AU - Antović, Jovan AU - Đorđević, Valentina PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1635 AB - Prothrombin Belgrade mutation is a result of the c.1787G>T mutation in the prothrombin gene, which leads to the substitution of Arg596 by Gln. This mutation is located in the antithrombin binding site and leads to the impaired inactivation of thrombin by antithrombin and antithrombin resistance, resulting in a thrombotic phenotype. Previous studies have shown the complex mechanism of this mutation, manifested with higher endogenous thrombin potential, lower prothrombin activity with normal prothrombin levels in carriers’ plasma. C3 - Research and Practice in Thrombosis and Haemostasis C3 - Research and Practice in Thrombosis and Haemostasis T1 - The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation EP - 1117 IS - 1 SP - 1117 VL - 4 UR - https://hdl.handle.net/21.15107/rcub_imagine_1635 ER -
@conference{ author = "Dunjić, Sofija and Cumbo, Marija and Gvozdenov, Maja and Taxiarchis, Apostolos and Tomić, Branko and Antović, Jovan and Đorđević, Valentina", year = "2020", abstract = "Prothrombin Belgrade mutation is a result of the c.1787G>T mutation in the prothrombin gene, which leads to the substitution of Arg596 by Gln. This mutation is located in the antithrombin binding site and leads to the impaired inactivation of thrombin by antithrombin and antithrombin resistance, resulting in a thrombotic phenotype. Previous studies have shown the complex mechanism of this mutation, manifested with higher endogenous thrombin potential, lower prothrombin activity with normal prothrombin levels in carriers’ plasma.", journal = "Research and Practice in Thrombosis and Haemostasis, Research and Practice in Thrombosis and Haemostasis", title = "The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation", pages = "1117-1117", number = "1", volume = "4", url = "https://hdl.handle.net/21.15107/rcub_imagine_1635" }
Dunjić, S., Cumbo, M., Gvozdenov, M., Taxiarchis, A., Tomić, B., Antović, J.,& Đorđević, V.. (2020). The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation. in Research and Practice in Thrombosis and Haemostasis, 4(1), 1117-1117. https://hdl.handle.net/21.15107/rcub_imagine_1635
Dunjić S, Cumbo M, Gvozdenov M, Taxiarchis A, Tomić B, Antović J, Đorđević V. The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation. in Research and Practice in Thrombosis and Haemostasis. 2020;4(1):1117-1117. https://hdl.handle.net/21.15107/rcub_imagine_1635 .
Dunjić, Sofija, Cumbo, Marija, Gvozdenov, Maja, Taxiarchis, Apostolos, Tomić, Branko, Antović, Jovan, Đorđević, Valentina, "The prothrombin Belgrade mutation causing antithrombin resistance does not affect fibrin clot formation" in Research and Practice in Thrombosis and Haemostasis, 4, no. 1 (2020):1117-1117, https://hdl.handle.net/21.15107/rcub_imagine_1635 .