Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology
Апстракт
: Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the treatment of
infections caused by multidrug-resistant A. baumannii. Since the reintroduction of colistin, a number
of mechanisms of colistin resistance in A. baumannii have been reported, including complete loss of
LPS by inactivation of the biosynthetic pathway, modifications of target LPS driven by the addition
of phosphoethanolamine (PEtN) moieties to lipid A mediated by the chromosomal pmrCAB operon
and eptA gene-encoded enzymes or plasmid-encoded mcr genes and efflux of colistin from the cell.
In addition to resistance to colistin, widespread heteroresistance is another feature of A. baumannii
that leads to colistin treatment failure. This review aims to present a critical assessment of relevant
published (>50 experimental papers) up-to-date knowledge on the molecular mechanisms of colistin
...
resistance in A. baumannii with a detailed review of implicated mutations and the global distribution
of colistin-resistant strains.
Кључне речи:
Acinetobacter baumannii / colistin resistance / lpx / pmr / mcr / LPS / lipid A / phosphoethanolamine transferase / epidemiologyИзвор:
Antibiotics, 2023, 12, 3, 516-Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200178 (Универзитет у Београду, Биолошки факултет) (RS-MESTD-inst-2020-200178)
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Novović, Katarina AU - Jovčić, Branko PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1786 AB - : Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the treatment of infections caused by multidrug-resistant A. baumannii. Since the reintroduction of colistin, a number of mechanisms of colistin resistance in A. baumannii have been reported, including complete loss of LPS by inactivation of the biosynthetic pathway, modifications of target LPS driven by the addition of phosphoethanolamine (PEtN) moieties to lipid A mediated by the chromosomal pmrCAB operon and eptA gene-encoded enzymes or plasmid-encoded mcr genes and efflux of colistin from the cell. In addition to resistance to colistin, widespread heteroresistance is another feature of A. baumannii that leads to colistin treatment failure. This review aims to present a critical assessment of relevant published (>50 experimental papers) up-to-date knowledge on the molecular mechanisms of colistin resistance in A. baumannii with a detailed review of implicated mutations and the global distribution of colistin-resistant strains. PB - MDPI T2 - Antibiotics T1 - Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology IS - 3 SP - 516 VL - 12 DO - 10.3390/antibiotics12030516 ER -
@article{ author = "Novović, Katarina and Jovčić, Branko", year = "2023", abstract = ": Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the treatment of infections caused by multidrug-resistant A. baumannii. Since the reintroduction of colistin, a number of mechanisms of colistin resistance in A. baumannii have been reported, including complete loss of LPS by inactivation of the biosynthetic pathway, modifications of target LPS driven by the addition of phosphoethanolamine (PEtN) moieties to lipid A mediated by the chromosomal pmrCAB operon and eptA gene-encoded enzymes or plasmid-encoded mcr genes and efflux of colistin from the cell. In addition to resistance to colistin, widespread heteroresistance is another feature of A. baumannii that leads to colistin treatment failure. This review aims to present a critical assessment of relevant published (>50 experimental papers) up-to-date knowledge on the molecular mechanisms of colistin resistance in A. baumannii with a detailed review of implicated mutations and the global distribution of colistin-resistant strains.", publisher = "MDPI", journal = "Antibiotics", title = "Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology", number = "3", pages = "516", volume = "12", doi = "10.3390/antibiotics12030516" }
Novović, K.,& Jovčić, B.. (2023). Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology. in Antibiotics MDPI., 12(3), 516. https://doi.org/10.3390/antibiotics12030516
Novović K, Jovčić B. Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology. in Antibiotics. 2023;12(3):516. doi:10.3390/antibiotics12030516 .
Novović, Katarina, Jovčić, Branko, "Colistin resistance in acinetobacter baumannii: Molecular mechanisms and epidemiology" in Antibiotics, 12, no. 3 (2023):516, https://doi.org/10.3390/antibiotics12030516 . .