Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer
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Aim To analyze the expression of autophagy markers p62,
LC3, and Beclin1 in ovarian cancer tissue and evaluate the
prognostic potential of these markers.
Methods The study enrolled 328 patients: 122 with epithelial ovarian carcinoma, 42 with atypical proliferative tumor, and 164 with benign epithelial ovarian tumor. The expression of p62, LC3, and Beclin1 was analyzed in central
and invasive tumor segments with immunohistochemistry
combined with tissue microarray. The expression levels of
the analyzed markers were correlated with relevant histopathology parameters.
Results The expression of all analyzed markers was most
remarkable in epithelial ovarian carcinoma. There was a
strong positive correlation between the expressions of p62
and LC3, while these two markers negatively correlated
with Beclin1. High-grade serous carcinoma had higher p62
and LC3 levels, and lower Beclin1 levels than other tumor
types. This expression profile was also observed in more
advanced tumor s...tages.
Conclusion Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous
carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype.
Кључне речи:
ovarian cancerИзвор:
Croatian Medical Journal, 2022, 63, 5, 453-460Издавач:
- Medicinska naklada (Croatia)
DOI: 10.3325/cmj.2022.63.453
ISSN: 0353-9504; 1332-8166 (Online)
WoS: 000907637200009
Scopus: 2-s2.0-85141166226
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jovanović, Ljubiša AU - Nikolić, Aleksandra AU - Dragičević, Sandra AU - Jović, Milena AU - Janković, Radmila PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2300 AB - Aim To analyze the expression of autophagy markers p62, LC3, and Beclin1 in ovarian cancer tissue and evaluate the prognostic potential of these markers. Methods The study enrolled 328 patients: 122 with epithelial ovarian carcinoma, 42 with atypical proliferative tumor, and 164 with benign epithelial ovarian tumor. The expression of p62, LC3, and Beclin1 was analyzed in central and invasive tumor segments with immunohistochemistry combined with tissue microarray. The expression levels of the analyzed markers were correlated with relevant histopathology parameters. Results The expression of all analyzed markers was most remarkable in epithelial ovarian carcinoma. There was a strong positive correlation between the expressions of p62 and LC3, while these two markers negatively correlated with Beclin1. High-grade serous carcinoma had higher p62 and LC3 levels, and lower Beclin1 levels than other tumor types. This expression profile was also observed in more advanced tumor stages. Conclusion Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype. PB - Medicinska naklada (Croatia) T2 - Croatian Medical Journal T1 - Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer EP - 460 IS - 5 SP - 453 VL - 63 DO - 10.3325/cmj.2022.63.453 ER -
@article{ author = "Jovanović, Ljubiša and Nikolić, Aleksandra and Dragičević, Sandra and Jović, Milena and Janković, Radmila", year = "2022", abstract = "Aim To analyze the expression of autophagy markers p62, LC3, and Beclin1 in ovarian cancer tissue and evaluate the prognostic potential of these markers. Methods The study enrolled 328 patients: 122 with epithelial ovarian carcinoma, 42 with atypical proliferative tumor, and 164 with benign epithelial ovarian tumor. The expression of p62, LC3, and Beclin1 was analyzed in central and invasive tumor segments with immunohistochemistry combined with tissue microarray. The expression levels of the analyzed markers were correlated with relevant histopathology parameters. Results The expression of all analyzed markers was most remarkable in epithelial ovarian carcinoma. There was a strong positive correlation between the expressions of p62 and LC3, while these two markers negatively correlated with Beclin1. High-grade serous carcinoma had higher p62 and LC3 levels, and lower Beclin1 levels than other tumor types. This expression profile was also observed in more advanced tumor stages. Conclusion Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype.", publisher = "Medicinska naklada (Croatia)", journal = "Croatian Medical Journal", title = "Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer", pages = "460-453", number = "5", volume = "63", doi = "10.3325/cmj.2022.63.453" }
Jovanović, L., Nikolić, A., Dragičević, S., Jović, M.,& Janković, R.. (2022). Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer. in Croatian Medical Journal Medicinska naklada (Croatia)., 63(5), 453-460. https://doi.org/10.3325/cmj.2022.63.453
Jovanović L, Nikolić A, Dragičević S, Jović M, Janković R. Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer. in Croatian Medical Journal. 2022;63(5):453-460. doi:10.3325/cmj.2022.63.453 .
Jovanović, Ljubiša, Nikolić, Aleksandra, Dragičević, Sandra, Jović, Milena, Janković, Radmila, "Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer" in Croatian Medical Journal, 63, no. 5 (2022):453-460, https://doi.org/10.3325/cmj.2022.63.453 . .