3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells
Само за регистроване кориснике
2011
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Different pharmacologically active components have been isolated from royal jelly. Some of them possess imunomodulatory activity, but the mechanisms of their effect on the immune system have not been elucidated yet. In this study we tested the effect of 3,10-dihydroxy-decanoic acid (3,10-DDA), a fatty acid isolated from royal jelly, on maturation and functions of human monocyte-derived dendritic cells (MoDCs). We showed that 3,10-DDA stimulated maturation of MoDCs by up-regulating the expression of CD40, CD54, CD86 and CD1a, and increased their allostimulatory potential in co-culture with allogeneic CD4(+)T cells. 3,10-DDA-treated MoDCs enhanced the production of IL-12 and IL-18, and stimulated the production of interferon-gamma in co-culture with allogeneic CD4(+)T cells, compared to control MoDCs. In contrast, the production of IL-10 was down-regulated. In conclusion, our results suggest that 3,10-DDA stimulates maturation and Th1 polarising capability of human MoDCs in vitro, which ...could be beneficial for anti-tumour and anti-viral immune responses.
Кључне речи:
Royal jelly / Phenotypisation / Monocyte-derived dendritic cells / Cytokines / 3,10-Dihydroxy-decanoic acidИзвор:
Food Chemistry, 2011, 126, 3, 1211-1217Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Military Medical Academy, Belgrade, Serbia [VMA 07-10/B.23]
- Serbian Academy of Science and Arts
- General Secretariat of Research and Technology of Greece
- "Korres" Natural Products, S.A
DOI: 10.1016/j.foodchem.2010.12.004
ISSN: 0308-8146
WoS: 000287349400060
Scopus: 2-s2.0-78751574062
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Dzopalić, Tanja AU - Vucević, Dragana AU - Tomić, Sergej AU - Đokić, Jelena AU - Chinou, Ioanna AU - Čolić, Miodrag PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/482 AB - Different pharmacologically active components have been isolated from royal jelly. Some of them possess imunomodulatory activity, but the mechanisms of their effect on the immune system have not been elucidated yet. In this study we tested the effect of 3,10-dihydroxy-decanoic acid (3,10-DDA), a fatty acid isolated from royal jelly, on maturation and functions of human monocyte-derived dendritic cells (MoDCs). We showed that 3,10-DDA stimulated maturation of MoDCs by up-regulating the expression of CD40, CD54, CD86 and CD1a, and increased their allostimulatory potential in co-culture with allogeneic CD4(+)T cells. 3,10-DDA-treated MoDCs enhanced the production of IL-12 and IL-18, and stimulated the production of interferon-gamma in co-culture with allogeneic CD4(+)T cells, compared to control MoDCs. In contrast, the production of IL-10 was down-regulated. In conclusion, our results suggest that 3,10-DDA stimulates maturation and Th1 polarising capability of human MoDCs in vitro, which could be beneficial for anti-tumour and anti-viral immune responses. PB - Elsevier Sci Ltd, Oxford T2 - Food Chemistry T1 - 3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells EP - 1217 IS - 3 SP - 1211 VL - 126 DO - 10.1016/j.foodchem.2010.12.004 ER -
@article{ author = "Dzopalić, Tanja and Vucević, Dragana and Tomić, Sergej and Đokić, Jelena and Chinou, Ioanna and Čolić, Miodrag", year = "2011", abstract = "Different pharmacologically active components have been isolated from royal jelly. Some of them possess imunomodulatory activity, but the mechanisms of their effect on the immune system have not been elucidated yet. In this study we tested the effect of 3,10-dihydroxy-decanoic acid (3,10-DDA), a fatty acid isolated from royal jelly, on maturation and functions of human monocyte-derived dendritic cells (MoDCs). We showed that 3,10-DDA stimulated maturation of MoDCs by up-regulating the expression of CD40, CD54, CD86 and CD1a, and increased their allostimulatory potential in co-culture with allogeneic CD4(+)T cells. 3,10-DDA-treated MoDCs enhanced the production of IL-12 and IL-18, and stimulated the production of interferon-gamma in co-culture with allogeneic CD4(+)T cells, compared to control MoDCs. In contrast, the production of IL-10 was down-regulated. In conclusion, our results suggest that 3,10-DDA stimulates maturation and Th1 polarising capability of human MoDCs in vitro, which could be beneficial for anti-tumour and anti-viral immune responses.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Food Chemistry", title = "3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells", pages = "1217-1211", number = "3", volume = "126", doi = "10.1016/j.foodchem.2010.12.004" }
Dzopalić, T., Vucević, D., Tomić, S., Đokić, J., Chinou, I.,& Čolić, M.. (2011). 3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells. in Food Chemistry Elsevier Sci Ltd, Oxford., 126(3), 1211-1217. https://doi.org/10.1016/j.foodchem.2010.12.004
Dzopalić T, Vucević D, Tomić S, Đokić J, Chinou I, Čolić M. 3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells. in Food Chemistry. 2011;126(3):1211-1217. doi:10.1016/j.foodchem.2010.12.004 .
Dzopalić, Tanja, Vucević, Dragana, Tomić, Sergej, Đokić, Jelena, Chinou, Ioanna, Čolić, Miodrag, "3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells" in Food Chemistry, 126, no. 3 (2011):1211-1217, https://doi.org/10.1016/j.foodchem.2010.12.004 . .