Regulation of the SOX3 Gene Expression by Retinoid Receptors
2011
Аутори
Nikčević, GordanaKovačević Grujičić, Nataša
Mojsin, Marija
Krstić, A.
Savić, T.
Stevanović, Milena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a soli...d base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood.
Кључне речи:
SOX3 / Retinoid receptors / Retinoic acid / Neuronal differentiation / Embryonal carcinoma cellsИзвор:
Physiological Research, 2011, 60, S83-S91Издавач:
- Acad Sciences Czech Republic, Inst Physiology, Prague 4
Финансирање / пројекти:
- Изучавање регулације експресије и функције хуманих SOX гена (RS-MESTD-MPN2006-2010-143028)
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.33549/physiolres.932184
ISSN: 0862-8408
PubMed: 21777018
WoS: 000296334200008
Scopus: 2-s2.0-84856593300
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Nikčević, Gordana AU - Kovačević Grujičić, Nataša AU - Mojsin, Marija AU - Krstić, A. AU - Savić, T. AU - Stevanović, Milena PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/485 AB - Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood. PB - Acad Sciences Czech Republic, Inst Physiology, Prague 4 T2 - Physiological Research T1 - Regulation of the SOX3 Gene Expression by Retinoid Receptors EP - S91 SP - S83 VL - 60 DO - 10.33549/physiolres.932184 ER -
@article{ author = "Nikčević, Gordana and Kovačević Grujičić, Nataša and Mojsin, Marija and Krstić, A. and Savić, T. and Stevanović, Milena", year = "2011", abstract = "Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood.", publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4", journal = "Physiological Research", title = "Regulation of the SOX3 Gene Expression by Retinoid Receptors", pages = "S91-S83", volume = "60", doi = "10.33549/physiolres.932184" }
Nikčević, G., Kovačević Grujičić, N., Mojsin, M., Krstić, A., Savić, T.,& Stevanović, M.. (2011). Regulation of the SOX3 Gene Expression by Retinoid Receptors. in Physiological Research Acad Sciences Czech Republic, Inst Physiology, Prague 4., 60, S83-S91. https://doi.org/10.33549/physiolres.932184
Nikčević G, Kovačević Grujičić N, Mojsin M, Krstić A, Savić T, Stevanović M. Regulation of the SOX3 Gene Expression by Retinoid Receptors. in Physiological Research. 2011;60:S83-S91. doi:10.33549/physiolres.932184 .
Nikčević, Gordana, Kovačević Grujičić, Nataša, Mojsin, Marija, Krstić, A., Savić, T., Stevanović, Milena, "Regulation of the SOX3 Gene Expression by Retinoid Receptors" in Physiological Research, 60 (2011):S83-S91, https://doi.org/10.33549/physiolres.932184 . .