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Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
(European Journal of Medicinal ChemistryEuropean Journal of Medicinal ChemistryEuropean Journal of Medicinal Chemistry, 2023)
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them ...
THE IMPACT OF NEXT-GENERATION SEQUENCING ON DIAGNOSIS AND TREATMENT OF RARE DISEASES
(Macedonian Academy of Sciences and Arts, 2023)
Introduction: Rare diseases are heterogeneous group of diseases, with one common characteristics, a
prevalence less than 1 in 2000 people. Vast majority of them are monogenic and finding pathogenic genetic
variants is ...
Potential of environmental Serratia from herbicide treated soil for pathogenicity in humans
(European Congress of Clinical Microbiology & Infectious Diseases, 2022)
Soils contain microorganisms capable of causing diseases in humans, either
as opportunistic or as obligate pathogens. The application of herbicides
increases the prevalence of antibiotic resistance genes and mobile ...
Microbial live interactions with textiles
(FEMS2023 Congress of European Microbiologists, 2023)
Microorganisms, especially soil-dwelling Streptomyces, have the potential to both degrade
and colour a variety of textiles. Pigments from Streptomycetes could serve as colouring
agents for different natural and synthetic ...
Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze
(Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo, 2023)
Multipla skleroza (MS) je hronična autoimunska bolest centralnog nervnog sistema (CNS) čiji osnovni
patogenetski mehanizmi obuhvataju neuroinflamaciju, demijelinizaciju i neurodegeneraciju. Glavno
patofiziološko obeležje ...
Probiotic characterization of Limosilactobacillus fermentum BGHV110 strain and its influence on innate immune response in Caenorhabditis elegans / Probiotička karakterizacija soja Limosilactobacillus fermentum BGHV110 i njegov uticaj na urođeni imunski odgovor kod Caenorhabditis elegans
(Centre for Evaluation in Education and Science, 2023)
Probiotic lactobacilli exhibit the potential to promote health benefits for the host. Thanks to its numerous beneficial effects on human health, Limosilactobacillus fermentum stood out as an excellent candidate for the ...
Outcome of a Serbian pilot initiative: Spinal muscular atrophy newborn screening over a 16-month period
(International Journal of Medical Genetic, 2023)
Background: Spinal muscular atrophy
(SMA) is the prevalent genetic cause of childhood
mortality. Pioneering treatments yield utmost advantages
only within the presymptomatic phase,
underlining the significance of newborn ...
Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365
(Beograd : Srpsko hemijsko društvo, 2023)
The genus Streptomyces has been studied for the vast secondary metabolite
production, biological activity of crude extracts, as well as colouring properties on textile
materials [1, 2]. Streptomyces sp. BV365 is a potent ...
The influence of Wilms' tumor 1 gene expression level on prognosis and risk stratification of acute promyelocytic leukemia patients
(Wiley, Hoboken, 2020)
Introduction Patients with acute promyelocytic leukemia (APL) are characterized by the highest expression of Wilms' tumor 1 (WT1) gene compared with other subtypes of acute myeloid leukemia, and yet this molecular marker ...
A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research
(Hemijska industrija (Chemical Industry), 2024)
Comprehensive research, particularly in evaluating drug efficacy, still heavily relies on the results obtained by the utilization of cell monolayers and animals. However, the inherent limitations of these models such as ...