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New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis
(Nature Publishing Group, London, 2011)
A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main ...
Molekularna osnova hronične limfocitne leukemije : korelacija između mutacionog statusa teških lanaca imunoglobulina i ekspresije apoptotskih gena / Molecular basis of chronic lymphocytic leukemia: correlation between the immunoglobulin heavy chain mutational status and the expression of apoptotic genes
(Univerzitet u Beogradu, Biološki fakultet, 2012)
Hronična limfocitna leukemija (HLL), najčešći tip leukemije u Evropi i Severnoj Americi, se manifestuje kao klonska ekspanzija zrelih CD5+ CD19+ CD23+ sIgM+/- B limfocita i karakteriše se izuzetno heterogenim kliničkim ...
Numerical and Biological Modeling Approach in the Analysis of the Cancer Viability and Apoptosis
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Biomedicine is a multidisciplinary branch of science that requires a clear approach to the
study and analysis of various life processes necessary for a deeper understanding of
human health. This research focuses on the ...
Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases
(MDPI, Basel, 2022)
Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype-phenotype correlation. ...
Molekularni mehanizmi patogeneze mijeloproliferativnih neoplazija : poremećaj ekspresije gena uključenih u proliferaciju i apoptozu / Molecular mechanisms of pathogenesis of myeloproliferative neoplasms: deregulation of genes involved in cell proliferation and apoptosis
(Univerzitet u Beogradu, Biološki fakultet, 2012)
Mijeloproliferativne neoplazije (MPN) su hronični hematološki maligniteti koji se odlikuju autonomnom proliferacijom opredeljenih progenitora hematopoeze i aberantnom aktivacijom tirozin kinaznih signalnih puteva u kombinaciji ...
Analiza ekspresije i uloge humanog gena SOX14 u neuralnoj diferencijaciji in vitro i regulaciji malignog fenotipa / Analysis of the expression and role of the human gene SOX14 in neural differentiation in vitro and in the regulation of malignant phenotype
(Univerzitet u Beogradu, Biološki fakultet, 2018)
Visok stepen očuvanosti tokom evolucije i činjenica da do danas nije opisan nijedan klinički sindrom povezan sa mutacijama u genu SOX14, ukazuju na značajnu ulogu ovog gena tokom embrionalnog razvića. Iako je prošlo dvadeset ...
Application of CRISPR/cas9 technology for in vitro disease modelling in glycogen storage disease type IB
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is an autosomal recessive disorder characterized by fasting hypoglycemia and the accumulation of glycogen in the liver, kidneys and intestinal mucosa. Recent studies ...
Structure optimisation of biopigment prodigiosin from Serratia marcescens ATCC 27117 and antimicrobial and anticancer properties of novel halogenated derivatives / Strukturna optimizacija biopigmenta prodigiozin iz bakterije Serratia marcescens ATCC 27117 ter antimikrobne in antitumorske lastnosti novih halogeniranih derivatov
(University of Nova Gorica, 2022)
Prodigiosins (PGs) are a class of bacterial secondary metabolites with remarkable biological activities and colour. In this study, optimised fermentative production of prodigiosin (PG) using waste processed meat as a ...
The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis
(MDPI, 2023)
Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple organ involvement. Skin changes present the hallmark of SSc and coincide with poor prognosis. Interstitial lung diseases (ILD) are the ...
Ekspresija Bcl2 gena kod pacijenata sa hroničnom limfocitnom leukemijom / Expression of the Bcl2 gene in chronic lymphocytic leukaemia patients
(Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac, 2015)
Hronična limfocitna leukemija (HLL) se manifestuje kao klonska ekspanzija zrelih B limfocita, čija se akumulacija pripisuje prvenstveno poremećajima procesa apoptoze. U HLL su uočene genetičke promene i aberantna ekspresija ...