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THE IMPACT OF NEXT-GENERATION SEQUENCING ON DIAGNOSIS AND TREATMENT OF RARE DISEASES
(Macedonian Academy of Sciences and Arts, 2023)
Introduction: Rare diseases are heterogeneous group of diseases, with one common characteristics, a
prevalence less than 1 in 2000 people. Vast majority of them are monogenic and finding pathogenic genetic
variants is ...
Potential of environmental Serratia from herbicide treated soil for pathogenicity in humans
(European Congress of Clinical Microbiology & Infectious Diseases, 2022)
Soils contain microorganisms capable of causing diseases in humans, either
as opportunistic or as obligate pathogens. The application of herbicides
increases the prevalence of antibiotic resistance genes and mobile ...
Microbial live interactions with textiles
(FEMS2023 Congress of European Microbiologists, 2023)
Microorganisms, especially soil-dwelling Streptomyces, have the potential to both degrade
and colour a variety of textiles. Pigments from Streptomycetes could serve as colouring
agents for different natural and synthetic ...
Outcome of a Serbian pilot initiative: Spinal muscular atrophy newborn screening over a 16-month period
(International Journal of Medical Genetic, 2023)
Background: Spinal muscular atrophy
(SMA) is the prevalent genetic cause of childhood
mortality. Pioneering treatments yield utmost advantages
only within the presymptomatic phase,
underlining the significance of newborn ...
Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365
(Beograd : Srpsko hemijsko društvo, 2023)
The genus Streptomyces has been studied for the vast secondary metabolite
production, biological activity of crude extracts, as well as colouring properties on textile
materials [1, 2]. Streptomyces sp. BV365 is a potent ...
A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research
(Hemijska industrija (Chemical Industry), 2024)
Comprehensive research, particularly in evaluating drug efficacy, still heavily relies on the results obtained by the utilization of cell monolayers and animals. However, the inherent limitations of these models such as ...
The pharmacogenomics of vincristine-induced peripheral neuropathy in pediatric acute lymphoblastic leukemia patients in Serbia
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Vincristine (VCR) is one of the key drugs in current treatment protocols for pediatric acute
lymphoblastic leukemia (ALL). By destabilization of microtubules, VCR arrests cells in metaphase,
inducing apoptosis of malignant ...
Application of Next-Generation Sequencing Technology and Establishment of Biobanks
(Karger, Basel, 2018)
Institute of Molecular Genetics and Genetic Engineering has
become widely recognized as an expert centre for rare diseases
(RD). It is the first institution is Serbia that applied NGS methodology in research and diagnostics ...
An analysis of rat beta(miny)-globin gene promoter
(Wiley, Hoboken, 1998)
Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway
(Georg Thieme Verlag Kg, Stuttgart, 2009)