Antibacterial and antifungal properties of guanylhydrazones
Authors
Ajdačić, VladimirLazić, Jelena
Mojicević, Marija
Segan, Sandra
Nikodinović-Runić, Jasmina
Opsenica, Igor M.
Article (Published version)
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Show full item recordAbstract
A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 ae g mL(-1), and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development.
Keywords:
iminoguanidines / guanylhydrazones / Candida spp. / antifungal activity / antibacterial activitySource:
Journal of the Serbian Chemical Society, 2017, 82, 6, 641-649Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Serbian Academy of Sciences and Arts
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-MESTD-Basic Research (BR or ON)-172008)
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.2298/JSC170213033A
ISSN: 0352-5139
WoS: 000408085700003
Scopus: 2-s2.0-85026736401
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Ajdačić, Vladimir AU - Lazić, Jelena AU - Mojicević, Marija AU - Segan, Sandra AU - Nikodinović-Runić, Jasmina AU - Opsenica, Igor M. PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1010 AB - A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 ae g mL(-1), and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Antibacterial and antifungal properties of guanylhydrazones EP - 649 IS - 6 SP - 641 VL - 82 DO - 10.2298/JSC170213033A ER -
@article{ author = "Ajdačić, Vladimir and Lazić, Jelena and Mojicević, Marija and Segan, Sandra and Nikodinović-Runić, Jasmina and Opsenica, Igor M.", year = "2017", abstract = "A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 ae g mL(-1), and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Antibacterial and antifungal properties of guanylhydrazones", pages = "649-641", number = "6", volume = "82", doi = "10.2298/JSC170213033A" }
Ajdačić, V., Lazić, J., Mojicević, M., Segan, S., Nikodinović-Runić, J.,& Opsenica, I. M.. (2017). Antibacterial and antifungal properties of guanylhydrazones. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 82(6), 641-649. https://doi.org/10.2298/JSC170213033A
Ajdačić V, Lazić J, Mojicević M, Segan S, Nikodinović-Runić J, Opsenica IM. Antibacterial and antifungal properties of guanylhydrazones. in Journal of the Serbian Chemical Society. 2017;82(6):641-649. doi:10.2298/JSC170213033A .
Ajdačić, Vladimir, Lazić, Jelena, Mojicević, Marija, Segan, Sandra, Nikodinović-Runić, Jasmina, Opsenica, Igor M., "Antibacterial and antifungal properties of guanylhydrazones" in Journal of the Serbian Chemical Society, 82, no. 6 (2017):641-649, https://doi.org/10.2298/JSC170213033A . .