Benzothiazole carbamates and amides as antiproliferative species
Nema prikaza
Autori
Videnović, MilicaMojsin, Marija
Stevanović, Milena
Opsenica, Igor
Srdić-Rajić, Tatjana
Solaja, Bogdan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.
Ključne reči:
NT2/D1 / MCF-7 / Benzothiazoles / Antiproliferative / AnoikisIzvor:
European Journal of Medicinal Chemistry, 2018, 157, 1096-1114Izdavač:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Finansiranje / projekti:
- Serbian Academy of Sciences and Arts
- Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A (RS-MESTD-Basic Research (BR or ON)-172008)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.1016/j.ejmech.2018.08.067
ISSN: 0223-5234
PubMed: 30179747
WoS: 000447480000079
Scopus: 2-s2.0-85054063702
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Videnović, Milica AU - Mojsin, Marija AU - Stevanović, Milena AU - Opsenica, Igor AU - Srdić-Rajić, Tatjana AU - Solaja, Bogdan PY - 2018 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1148 AB - A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Benzothiazole carbamates and amides as antiproliferative species EP - 1114 SP - 1096 VL - 157 DO - 10.1016/j.ejmech.2018.08.067 ER -
@article{ author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Solaja, Bogdan", year = "2018", abstract = "A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Benzothiazole carbamates and amides as antiproliferative species", pages = "1114-1096", volume = "157", doi = "10.1016/j.ejmech.2018.08.067" }
Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Solaja, B.. (2018). Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114. https://doi.org/10.1016/j.ejmech.2018.08.067
Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Solaja B. Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry. 2018;157:1096-1114. doi:10.1016/j.ejmech.2018.08.067 .
Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Solaja, Bogdan, "Benzothiazole carbamates and amides as antiproliferative species" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114, https://doi.org/10.1016/j.ejmech.2018.08.067 . .