Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea
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2020
Authors
Jovanović, Svetlana P.Syrgiannis, Zois
Budimir, Milica D.
Milivojević, Dusan D.
Jovanović, Dragana J.
Pavlović, Vladimir B.
Papan, Jelena M.
Bartenwerfer, Malte
Mojsin, Marija
Stevanović, Milena
Marković, Biljana M. Todorovic
Article (Published version)
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Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the prod...uction of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.
Keywords:
Singlet oxygen / Photodynamic therapy / Graphene quantum dots / Cytotoxicity / AntioxidantSource:
Materials Science & Engineering C-Materials For Biological Applications, 2020, 109Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Thin films of single wall carbon nanotubes and graphene for electronic application (RS-MESTD-Basic Research (BR or ON)-172003)
- Studying signal transduction pathways and epigenetic mechanisms that control human SOX genes expression: further insight into their roles in cell fate determination and differentiation (RS-MESTD-Basic Research (BR or ON)-173051)
- 451-03-01732/2017-09/7
DOI: 10.1016/j.msec.2019.110539
ISSN: 0928-4931
PubMed: 32229000
WoS: 000527394600048
Scopus: 2-s2.0-85076495597
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jovanović, Svetlana P. AU - Syrgiannis, Zois AU - Budimir, Milica D. AU - Milivojević, Dusan D. AU - Jovanović, Dragana J. AU - Pavlović, Vladimir B. AU - Papan, Jelena M. AU - Bartenwerfer, Malte AU - Mojsin, Marija AU - Stevanović, Milena AU - Marković, Biljana M. Todorovic PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1380 AB - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. PB - Elsevier, Amsterdam T2 - Materials Science & Engineering C-Materials For Biological Applications T1 - Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea VL - 109 DO - 10.1016/j.msec.2019.110539 ER -
@article{ author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica D. and Milivojević, Dusan D. and Jovanović, Dragana J. and Pavlović, Vladimir B. and Papan, Jelena M. and Bartenwerfer, Malte and Mojsin, Marija and Stevanović, Milena and Marković, Biljana M. Todorovic", year = "2020", abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.", publisher = "Elsevier, Amsterdam", journal = "Materials Science & Engineering C-Materials For Biological Applications", title = "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea", volume = "109", doi = "10.1016/j.msec.2019.110539" }
Jovanović, S. P., Syrgiannis, Z., Budimir, M. D., Milivojević, D. D., Jovanović, D. J., Pavlović, V. B., Papan, J. M., Bartenwerfer, M., Mojsin, M., Stevanović, M.,& Marković, B. M. T.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials For Biological Applications Elsevier, Amsterdam., 109. https://doi.org/10.1016/j.msec.2019.110539
Jovanović SP, Syrgiannis Z, Budimir MD, Milivojević DD, Jovanović DJ, Pavlović VB, Papan JM, Bartenwerfer M, Mojsin M, Stevanović M, Marković BMT. Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials For Biological Applications. 2020;109. doi:10.1016/j.msec.2019.110539 .
Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica D., Milivojević, Dusan D., Jovanović, Dragana J., Pavlović, Vladimir B., Papan, Jelena M., Bartenwerfer, Malte, Mojsin, Marija, Stevanović, Milena, Marković, Biljana M. Todorovic, "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea" in Materials Science & Engineering C-Materials For Biological Applications, 109 (2020), https://doi.org/10.1016/j.msec.2019.110539 . .