Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands
Autori
Durić, Sonja Z.Vojnović, Sandra
Andrejević, Tina P.
Stevanović, Nevena Lj.
Savić, Nada D.
Nikodinović-Runić, Jasmina
Glišić, Biljana
Djuran, Milos
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}(n) (1), {[Ag(bpa)(2)](CF3SO3H2O)-H-.}(n) (2) and {[Ag(bpe)]CF3SO3}(n) (3). In complexes 1-3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The silver(I) complexes 1-3 showed selectivity towards Candida spp. and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 mu g/mL and the growth of E. coli, with MIC value being 12.5 mu g/mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pa...thogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1-3. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.
Izvor:
Bioinorganic Chemistry and Applications, 2020, 2020Izdavač:
- Hindawi Ltd, London
Finansiranje / projekti:
- Serbian Academy of Sciences and Arts [01-2019-F65, F128]
- Sinteza novih kompleksa metala i ispitivanje njihovih reakcija sa peptidima (RS-MESTD-Basic Research (BR or ON)-172036)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1155/2020/3812050
ISSN: 1565-3633
WoS: 000530340500001
Scopus: 2-s2.0-85085095387
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Durić, Sonja Z. AU - Vojnović, Sandra AU - Andrejević, Tina P. AU - Stevanović, Nevena Lj. AU - Savić, Nada D. AU - Nikodinović-Runić, Jasmina AU - Glišić, Biljana AU - Djuran, Milos PY - 2020 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1401 AB - 1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}(n) (1), {[Ag(bpa)(2)](CF3SO3H2O)-H-.}(n) (2) and {[Ag(bpe)]CF3SO3}(n) (3). In complexes 1-3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The silver(I) complexes 1-3 showed selectivity towards Candida spp. and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 mu g/mL and the growth of E. coli, with MIC value being 12.5 mu g/mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1-3. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action. PB - Hindawi Ltd, London T2 - Bioinorganic Chemistry and Applications T1 - Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands VL - 2020 DO - 10.1155/2020/3812050 ER -
@article{ author = "Durić, Sonja Z. and Vojnović, Sandra and Andrejević, Tina P. and Stevanović, Nevena Lj. and Savić, Nada D. and Nikodinović-Runić, Jasmina and Glišić, Biljana and Djuran, Milos ", year = "2020", abstract = "1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}(n) (1), {[Ag(bpa)(2)](CF3SO3H2O)-H-.}(n) (2) and {[Ag(bpe)]CF3SO3}(n) (3). In complexes 1-3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The silver(I) complexes 1-3 showed selectivity towards Candida spp. and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 mu g/mL and the growth of E. coli, with MIC value being 12.5 mu g/mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1-3. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.", publisher = "Hindawi Ltd, London", journal = "Bioinorganic Chemistry and Applications", title = "Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands", volume = "2020", doi = "10.1155/2020/3812050" }
Durić, S. Z., Vojnović, S., Andrejević, T. P., Stevanović, N. Lj., Savić, N. D., Nikodinović-Runić, J., Glišić, B.,& Djuran, M.. (2020). Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands. in Bioinorganic Chemistry and Applications Hindawi Ltd, London., 2020. https://doi.org/10.1155/2020/3812050
Durić SZ, Vojnović S, Andrejević TP, Stevanović NL, Savić ND, Nikodinović-Runić J, Glišić B, Djuran M. Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands. in Bioinorganic Chemistry and Applications. 2020;2020. doi:10.1155/2020/3812050 .
Durić, Sonja Z., Vojnović, Sandra, Andrejević, Tina P., Stevanović, Nevena Lj., Savić, Nada D., Nikodinović-Runić, Jasmina, Glišić, Biljana, Djuran, Milos , "Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands" in Bioinorganic Chemistry and Applications, 2020 (2020), https://doi.org/10.1155/2020/3812050 . .