Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone)
2022
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Аутори
Atanase, Leonard IonutSalhi, Slim
Cucoveica, Oana
Ponjavić, Marijana
Nikodinović-Runić, Jasmina
Delaite, Christelle
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(epsilon-caprolactone)-b-poly(ethylene adipate)-b-poly(epsilon-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained. The starting point of these copolymers was a dihydroxy-PEA precursor with a molar mass (M-n) of 2500 g/mol. Mn values of the PCL varied between 1000 and 10,000 g/mol. Both the precursors and the copolymers were characterized using different physicochemical methods, such as: NMR, SEC, Maldi-TOFF, DSC, and ATG. The molecular characteristics of the copolymers were in a direct correlation with the sequence length of the PCL. Enzymatic degradability ...studies were also conducted by using cell-free extract containing Pseudomonas aeruginosa PAO1 for 10 and 21 days, and it appeared that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples. In fact, copolymer PCL7000-PEA(2500)-PCL7000 had a weight loss of around 50% after 10 days whereas the weight loss of the homopolymer PCL, with a similar M-n of 14,000 g/mol, was only 6%. The results obtained in this study indicate that these copolymer samples can be further used for the preparation of drug delivery systems with modulated biodegradability.
Кључне речи:
polyesters / PEA / PCL / copolymers / biodegradabilityИзвор:
Polymers, 2022, 14, 18Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Romanian Ministry of Education and Research, CNCS-UEFISCDI [PN-III-P1-1.1-TE-2019-0664]
DOI: 10.3390/polym14183736
ISSN: 2073-4360
WoS: 000857519300001
Scopus: 2-s2.0-85138827330
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Atanase, Leonard Ionut AU - Salhi, Slim AU - Cucoveica, Oana AU - Ponjavić, Marijana AU - Nikodinović-Runić, Jasmina AU - Delaite, Christelle PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1520 AB - Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(epsilon-caprolactone)-b-poly(ethylene adipate)-b-poly(epsilon-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained. The starting point of these copolymers was a dihydroxy-PEA precursor with a molar mass (M-n) of 2500 g/mol. Mn values of the PCL varied between 1000 and 10,000 g/mol. Both the precursors and the copolymers were characterized using different physicochemical methods, such as: NMR, SEC, Maldi-TOFF, DSC, and ATG. The molecular characteristics of the copolymers were in a direct correlation with the sequence length of the PCL. Enzymatic degradability studies were also conducted by using cell-free extract containing Pseudomonas aeruginosa PAO1 for 10 and 21 days, and it appeared that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples. In fact, copolymer PCL7000-PEA(2500)-PCL7000 had a weight loss of around 50% after 10 days whereas the weight loss of the homopolymer PCL, with a similar M-n of 14,000 g/mol, was only 6%. The results obtained in this study indicate that these copolymer samples can be further used for the preparation of drug delivery systems with modulated biodegradability. PB - MDPI, Basel T2 - Polymers T1 - Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone) IS - 18 VL - 14 DO - 10.3390/polym14183736 ER -
@article{ author = "Atanase, Leonard Ionut and Salhi, Slim and Cucoveica, Oana and Ponjavić, Marijana and Nikodinović-Runić, Jasmina and Delaite, Christelle", year = "2022", abstract = "Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(epsilon-caprolactone)-b-poly(ethylene adipate)-b-poly(epsilon-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained. The starting point of these copolymers was a dihydroxy-PEA precursor with a molar mass (M-n) of 2500 g/mol. Mn values of the PCL varied between 1000 and 10,000 g/mol. Both the precursors and the copolymers were characterized using different physicochemical methods, such as: NMR, SEC, Maldi-TOFF, DSC, and ATG. The molecular characteristics of the copolymers were in a direct correlation with the sequence length of the PCL. Enzymatic degradability studies were also conducted by using cell-free extract containing Pseudomonas aeruginosa PAO1 for 10 and 21 days, and it appeared that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples. In fact, copolymer PCL7000-PEA(2500)-PCL7000 had a weight loss of around 50% after 10 days whereas the weight loss of the homopolymer PCL, with a similar M-n of 14,000 g/mol, was only 6%. The results obtained in this study indicate that these copolymer samples can be further used for the preparation of drug delivery systems with modulated biodegradability.", publisher = "MDPI, Basel", journal = "Polymers", title = "Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone)", number = "18", volume = "14", doi = "10.3390/polym14183736" }
Atanase, L. I., Salhi, S., Cucoveica, O., Ponjavić, M., Nikodinović-Runić, J.,& Delaite, C.. (2022). Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone). in Polymers MDPI, Basel., 14(18). https://doi.org/10.3390/polym14183736
Atanase LI, Salhi S, Cucoveica O, Ponjavić M, Nikodinović-Runić J, Delaite C. Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone). in Polymers. 2022;14(18). doi:10.3390/polym14183736 .
Atanase, Leonard Ionut, Salhi, Slim, Cucoveica, Oana, Ponjavić, Marijana, Nikodinović-Runić, Jasmina, Delaite, Christelle, "Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(epsilon-caprolactone)" in Polymers, 14, no. 18 (2022), https://doi.org/10.3390/polym14183736 . .