Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin
Autori
Milisavljević, MiraZivković, S.
Pekmezović, M.
Stanković, Nada
Vojnović, Sandra
Vasiljević, Branka
Šenerović, Lidija
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colleto...trichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection.
Ključne reči:
polyene macrolide / plant pathogens / human pathogens / fungi / 33-didehydroroflamycoin / 32Izvor:
Journal of Applied Microbiology, 2015, 118, 6, 1426-1434Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
- Molekularni mehanizmi odgovora biljaka na abiotički stres-uloga transkripcionih faktora i malih RNK i analiza genetičkog diverziteta biljnih kultura od interesa za poljoprivredu i biotehnologiju (RS-MESTD-Basic Research (BR or ON)-173005)
- Razrada integrisanog upravljanja i primene savremenih principa suzbijanja štetnih organizama u zaštiti bilja (RS-MESTD-Technological Development (TD or TR)-31018)
Napomena:
- This is the peer reviewed version of the paper: Milisavljevic, M., Zivkovic, S., Pekmezovic, M., Stankovic, N., Vojnovic, S., Vasiljevic, B., & Senerovic, L. (2015). Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin. Journal of Applied Microbiology, 118(6), 1426–1434. https://doi.org/10.1111/jam.12811
- https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/jam.12811
Povezane informacije:
- Druga verzija
https://imagine.imgge.bg.ac.rs/handle/123456789/876 - Druga verzija
https://doi.org/10.1111/jam.12811
DOI: 10.1111/jam.12811
ISSN: 1364-5072
PubMed: 25810243
WoS: 000354570600017
Scopus: 2-s2.0-84929509136
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Milisavljević, Mira AU - Zivković, S. AU - Pekmezović, M. AU - Stanković, Nada AU - Vojnović, Sandra AU - Vasiljević, Branka AU - Šenerović, Lidija PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1608 AB - AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colletotrichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection. PB - Wiley, Hoboken T2 - Journal of Applied Microbiology T1 - Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin EP - 1434 IS - 6 SP - 1426 VL - 118 DO - 10.1111/jam.12811 ER -
@article{ author = "Milisavljević, Mira and Zivković, S. and Pekmezović, M. and Stanković, Nada and Vojnović, Sandra and Vasiljević, Branka and Šenerović, Lidija", year = "2015", abstract = "AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colletotrichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection.", publisher = "Wiley, Hoboken", journal = "Journal of Applied Microbiology", title = "Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin", pages = "1434-1426", number = "6", volume = "118", doi = "10.1111/jam.12811" }
Milisavljević, M., Zivković, S., Pekmezović, M., Stanković, N., Vojnović, S., Vasiljević, B.,& Šenerović, L.. (2015). Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin. in Journal of Applied Microbiology Wiley, Hoboken., 118(6), 1426-1434. https://doi.org/10.1111/jam.12811
Milisavljević M, Zivković S, Pekmezović M, Stanković N, Vojnović S, Vasiljević B, Šenerović L. Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin. in Journal of Applied Microbiology. 2015;118(6):1426-1434. doi:10.1111/jam.12811 .
Milisavljević, Mira, Zivković, S., Pekmezović, M., Stanković, Nada, Vojnović, Sandra, Vasiljević, Branka, Šenerović, Lidija, "Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin" in Journal of Applied Microbiology, 118, no. 6 (2015):1426-1434, https://doi.org/10.1111/jam.12811 . .