Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
Authors
Dragasevic, SanjaStanković, Biljana
Kotur, Nikola
Milutinovic, Aleksandra Sokic
Milovanovic, Tamara
Stojkovic Lalosevic, Milica
Stojanovic, Maja
Pavlović, Sonja
Popovic, Dragan
Article (Published version)
Metadata
Show full item recordAbstract
Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption..., transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment.
Keywords:
B12 / B9 / genetics / IBD / iron / vitamin A / vitamin D / zincSource:
Life, 2022, 12, 10, 1623-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Dragasevic, Sanja AU - Stanković, Biljana AU - Kotur, Nikola AU - Milutinovic, Aleksandra Sokic AU - Milovanovic, Tamara AU - Stojkovic Lalosevic, Milica AU - Stojanovic, Maja AU - Pavlović, Sonja AU - Popovic, Dragan PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1664 AB - Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment. T2 - Life T2 - Life T1 - Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease IS - 10 SP - 1623 VL - 12 DO - 10.3390/life12101623 ER -
@article{ author = "Dragasevic, Sanja and Stanković, Biljana and Kotur, Nikola and Milutinovic, Aleksandra Sokic and Milovanovic, Tamara and Stojkovic Lalosevic, Milica and Stojanovic, Maja and Pavlović, Sonja and Popovic, Dragan", year = "2022", abstract = "Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment.", journal = "Life, Life", title = "Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease", number = "10", pages = "1623", volume = "12", doi = "10.3390/life12101623" }
Dragasevic, S., Stanković, B., Kotur, N., Milutinovic, A. S., Milovanovic, T., Stojkovic Lalosevic, M., Stojanovic, M., Pavlović, S.,& Popovic, D.. (2022). Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease. in Life, 12(10), 1623. https://doi.org/10.3390/life12101623
Dragasevic S, Stanković B, Kotur N, Milutinovic AS, Milovanovic T, Stojkovic Lalosevic M, Stojanovic M, Pavlović S, Popovic D. Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease. in Life. 2022;12(10):1623. doi:10.3390/life12101623 .
Dragasevic, Sanja, Stanković, Biljana, Kotur, Nikola, Milutinovic, Aleksandra Sokic, Milovanovic, Tamara, Stojkovic Lalosevic, Milica, Stojanovic, Maja, Pavlović, Sonja, Popovic, Dragan, "Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease" in Life, 12, no. 10 (2022):1623, https://doi.org/10.3390/life12101623 . .