Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)
Samo za registrovane korisnike
2023
Autori
Başpınar, YaseminGürbüz, Perihan
Dilem Doğan, Şengül
Gözde Gündüz, Miyase
Aleksić, Ivana
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Yavuz Paksoy, Mehmet
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds... isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.
Ključne reči:
Antibacterial / antifungal / cancer / molecular modeling / Pulicaria spIzvor:
Chemistry & Biodiversity, 2023, 20, e202300134-Finansiranje / projekti:
- The authors are indebted to the Research Foundation of Erciyes University (Project Number: TYL-2020-10492) for financially supporting the project. MGG would like to thank Prof. Dr. Gerhard Wolber, Freie Universität Berlin, for providing the license for LigandScout 4.4. IA, SV.
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200042 (Univerzitet u Beogradu, Institut za molekularnu genetiku i genetičko inženjerstvo) (RS-MESTD-inst-2020-200042)
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202300134https://imagine.imgge.bg.ac.rs/handle/123456789/1798
Kolekcije
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Başpınar, Yasemin AU - Gürbüz, Perihan AU - Dilem Doğan, Şengül AU - Gözde Gündüz, Miyase AU - Aleksić, Ivana AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina AU - Yavuz Paksoy, Mehmet PY - 2023 UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202300134 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1798 AB - This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment. T2 - Chemistry & Biodiversity T1 - Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae) SP - e202300134 VL - 20 DO - 10.1002/cbdv.202300134 ER -
@article{ author = "Başpınar, Yasemin and Gürbüz, Perihan and Dilem Doğan, Şengül and Gözde Gündüz, Miyase and Aleksić, Ivana and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Yavuz Paksoy, Mehmet", year = "2023", abstract = "This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.", journal = "Chemistry & Biodiversity", title = "Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)", pages = "e202300134", volume = "20", doi = "10.1002/cbdv.202300134" }
Başpınar, Y., Gürbüz, P., Dilem Doğan, Ş., Gözde Gündüz, M., Aleksić, I., Vojnović, S., Nikodinović-Runić, J.,& Yavuz Paksoy, M.. (2023). Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae). in Chemistry & Biodiversity, 20, e202300134. https://doi.org/10.1002/cbdv.202300134
Başpınar Y, Gürbüz P, Dilem Doğan Ş, Gözde Gündüz M, Aleksić I, Vojnović S, Nikodinović-Runić J, Yavuz Paksoy M. Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae). in Chemistry & Biodiversity. 2023;20:e202300134. doi:10.1002/cbdv.202300134 .
Başpınar, Yasemin, Gürbüz, Perihan, Dilem Doğan, Şengül, Gözde Gündüz, Miyase, Aleksić, Ivana, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Yavuz Paksoy, Mehmet, "Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)" in Chemistry & Biodiversity, 20 (2023):e202300134, https://doi.org/10.1002/cbdv.202300134 . .