Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate
Modern approaches in research of the molecular basis of prostate cancer
Authors
Dobrijević, ZoranaMatijašević-Joković, Suzana
Branković, Ana
Djordjević, Ana
Popović, Milica
Brajušković, Goran
Contributors
Pavlović, SonjaBook part (Published version)
![](/themes/Mirageimagine//images/creativecommons/arr.png)
Metadata
Show full item recordAbstract
U ovom radu preglednog tipa prikazano je desetogodišnje iskustvo istraživačkog tima PROSTATSERBIA
koji za temu svog istraživanja ima molekularnu osnovu karcinoma prostate (KP). Centar
za humanu molekularnu genetiku Biološkog fakulteta Univerziteta u Beogradu poseduje kolekciju
uzoraka i banku podataka za gotovo 1000 muškaraca sa bolestima prostate (KP i benigna hiperplazija
prostate) i preko 350 muškaraca bez znakova bolesti prostate iz populacije Republike Srbije. Najveći
broj studija bio je dizajniran kao studije asocijacije odabranih genetičkih varijanti sa rizikom za
razvoj i progresiju KP. U ovim studijama slučajeva i kontola ispitivane su genetičke varijente kako u genima
za proteine i nekodirajuće molekule RNK, tako i u nekodirajućim regionima genoma (tzv. „genskim
pustinjama“). Pored studija slučajeva i kontrola, sprovođene su i meta-analize kao i analize
statističkih epistatičkih interakcija analiziranih genetičkih varijanti. Krajnji cilj ovih studija je kreiranje
al...goritma za procenu rizika za progresiju bolesti koji bi se koristio u fazi aktivnog praćenja bolesnika
sa ranodijagnostikovanim KP. U poslednje vreme, istraživanja su usmerena na egzozome i njihov makromolekulski
sadržaj (proteine i nekodirajuće molekule RNK) kao potencijalne biološke markere
tečne biopsije KP. Pored toga, biološki makromolekuli na površini egzozoma predstavljaju i ciljane
molekule u novim strategijama lečenja KP.
This review-type paper will present the ten-year experience of the PROSTATSERBIA research team,
which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Molecular
Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a
data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for
over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies
were designed as studies of association of selected genetic variants with the risk for development
and progression of PCa. In these case-control studies, genetic variants were examined both in genes
for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene
deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epistatic
interactions of the analyzed genetic variants were conducted. The main goal of all these st...udies was
to create an algorithm for risk assessment for disease progression that would be used in the phase of
active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on
exosomes and their macromolecular content (proteins and microRNAs) as potential biological markers
of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent
target molecules for new PCa treatment strategies.
Keywords:
karcinom prostate / studije asocijacije / meta-analize / genetičke varijante / egzozomi / mikroRNK / PSMA / prostate cancer / association studies / meta-analysis / genetic variants / exosomes / microRNA / PSMASource:
Trendovi u molekularnoj Biologiji, 2022, 2, 63-74Publisher:
- Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
Funding / projects:
- Analysis of the structural genome changes as a diagnostic and prognostic parameter of human diseases (RS-MESTD-Basic Research (BR or ON)-173016)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200178 (University of Belgrade, Faculty of Biology) (RS-MESTD-inst-2020-200178)
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CHAP AU - Dobrijević, Zorana AU - Matijašević-Joković, Suzana AU - Branković, Ana AU - Djordjević, Ana AU - Popović, Milica AU - Brajušković, Goran PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1813 AB - U ovom radu preglednog tipa prikazano je desetogodišnje iskustvo istraživačkog tima PROSTATSERBIA koji za temu svog istraživanja ima molekularnu osnovu karcinoma prostate (KP). Centar za humanu molekularnu genetiku Biološkog fakulteta Univerziteta u Beogradu poseduje kolekciju uzoraka i banku podataka za gotovo 1000 muškaraca sa bolestima prostate (KP i benigna hiperplazija prostate) i preko 350 muškaraca bez znakova bolesti prostate iz populacije Republike Srbije. Najveći broj studija bio je dizajniran kao studije asocijacije odabranih genetičkih varijanti sa rizikom za razvoj i progresiju KP. U ovim studijama slučajeva i kontola ispitivane su genetičke varijente kako u genima za proteine i nekodirajuće molekule RNK, tako i u nekodirajućim regionima genoma (tzv. „genskim pustinjama“). Pored studija slučajeva i kontrola, sprovođene su i meta-analize kao i analize statističkih epistatičkih interakcija analiziranih genetičkih varijanti. Krajnji cilj ovih studija je kreiranje algoritma za procenu rizika za progresiju bolesti koji bi se koristio u fazi aktivnog praćenja bolesnika sa ranodijagnostikovanim KP. U poslednje vreme, istraživanja su usmerena na egzozome i njihov makromolekulski sadržaj (proteine i nekodirajuće molekule RNK) kao potencijalne biološke markere tečne biopsije KP. Pored toga, biološki makromolekuli na površini egzozoma predstavljaju i ciljane molekule u novim strategijama lečenja KP. AB - This review-type paper will present the ten-year experience of the PROSTATSERBIA research team, which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Molecular Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies were designed as studies of association of selected genetic variants with the risk for development and progression of PCa. In these case-control studies, genetic variants were examined both in genes for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epistatic interactions of the analyzed genetic variants were conducted. The main goal of all these studies was to create an algorithm for risk assessment for disease progression that would be used in the phase of active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on exosomes and their macromolecular content (proteins and microRNAs) as potential biological markers of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent target molecules for new PCa treatment strategies. PB - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo T2 - Trendovi u molekularnoj Biologiji T1 - Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate T1 - Modern approaches in research of the molecular basis of prostate cancer EP - 74 IS - 2 SP - 63 UR - https://hdl.handle.net/21.15107/rcub_imagine_1813 ER -
@inbook{ author = "Dobrijević, Zorana and Matijašević-Joković, Suzana and Branković, Ana and Djordjević, Ana and Popović, Milica and Brajušković, Goran", year = "2022", abstract = "U ovom radu preglednog tipa prikazano je desetogodišnje iskustvo istraživačkog tima PROSTATSERBIA koji za temu svog istraživanja ima molekularnu osnovu karcinoma prostate (KP). Centar za humanu molekularnu genetiku Biološkog fakulteta Univerziteta u Beogradu poseduje kolekciju uzoraka i banku podataka za gotovo 1000 muškaraca sa bolestima prostate (KP i benigna hiperplazija prostate) i preko 350 muškaraca bez znakova bolesti prostate iz populacije Republike Srbije. Najveći broj studija bio je dizajniran kao studije asocijacije odabranih genetičkih varijanti sa rizikom za razvoj i progresiju KP. U ovim studijama slučajeva i kontola ispitivane su genetičke varijente kako u genima za proteine i nekodirajuće molekule RNK, tako i u nekodirajućim regionima genoma (tzv. „genskim pustinjama“). Pored studija slučajeva i kontrola, sprovođene su i meta-analize kao i analize statističkih epistatičkih interakcija analiziranih genetičkih varijanti. Krajnji cilj ovih studija je kreiranje algoritma za procenu rizika za progresiju bolesti koji bi se koristio u fazi aktivnog praćenja bolesnika sa ranodijagnostikovanim KP. U poslednje vreme, istraživanja su usmerena na egzozome i njihov makromolekulski sadržaj (proteine i nekodirajuće molekule RNK) kao potencijalne biološke markere tečne biopsije KP. Pored toga, biološki makromolekuli na površini egzozoma predstavljaju i ciljane molekule u novim strategijama lečenja KP., This review-type paper will present the ten-year experience of the PROSTATSERBIA research team, which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Molecular Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies were designed as studies of association of selected genetic variants with the risk for development and progression of PCa. In these case-control studies, genetic variants were examined both in genes for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epistatic interactions of the analyzed genetic variants were conducted. The main goal of all these studies was to create an algorithm for risk assessment for disease progression that would be used in the phase of active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on exosomes and their macromolecular content (proteins and microRNAs) as potential biological markers of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent target molecules for new PCa treatment strategies.", publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo", journal = "Trendovi u molekularnoj Biologiji", booktitle = "Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate, Modern approaches in research of the molecular basis of prostate cancer", pages = "74-63", number = "2", url = "https://hdl.handle.net/21.15107/rcub_imagine_1813" }
Dobrijević, Z., Matijašević-Joković, S., Branković, A., Djordjević, A., Popović, M.,& Brajušković, G.. (2022). Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate. in Trendovi u molekularnoj Biologiji Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 63-74. https://hdl.handle.net/21.15107/rcub_imagine_1813
Dobrijević Z, Matijašević-Joković S, Branković A, Djordjević A, Popović M, Brajušković G. Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate. in Trendovi u molekularnoj Biologiji. 2022;(2):63-74. https://hdl.handle.net/21.15107/rcub_imagine_1813 .
Dobrijević, Zorana, Matijašević-Joković, Suzana, Branković, Ana, Djordjević, Ana, Popović, Milica, Brajušković, Goran, "Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate" in Trendovi u molekularnoj Biologiji, no. 2 (2022):63-74, https://hdl.handle.net/21.15107/rcub_imagine_1813 .