Uloga hsa-miR-93-5p u kolorektalnom karcinomu
Role of hsa-miR-93-5p in colorectal cancer
Abstract
Kolorektalni karcinom predstavlja heterogenu bolest koja zauzima treće i drugo mesto na svetu po stepenu
incidence i stopi mortaliteta, respektivno. Poznato je da mikroRNK molekuli imaju ključne uloge u
procesu patogeneze, progresije i metastaziranja kolorektalnog karcinoma, ali i rezistenciji na hemioterapiju.
U različitim tumorima je pokazano da hsa-miR-93-5p može imati onkogenu, ali i tumor-supresorsku
ulogu. Ovaj rad ima za cilj da predstavi dosadašnja saznanja o ulozi hsa-miR-93-5p u procesima vezanim
za kolorektalnu karcinogenezu, metastaziranje i odgovor na hemioterapiju kod pacijenata sa kolorektalnim
karcinomom. Rad takođe razmatra hsa-miR-93-5p kao potencijalni prognostički i prediktivni biomarker
i primenu ovog molekula u kliničkoj praksi.
Colorectal cancer is a heterogeneous disease that ranks third and second globally in terms of incidence
and mortality rates, respectively. MicroRNAs have been implicated in the growth, progression, metastasis
and response to therapy of different tumors, including colorectal cancer. Hsa-miR-93-5p has been
reported to have oncogenic and tumor-suppressive roles in different tumor kinds. This review article aims
to present the current knowledge on the role of hsa-miR-93-5p in the processes related to colorectal carcinogenesis,
metastasis and response to chemotherapy in patients with primary and metastatic colorectal
cancer. Also, the role of hsa-miR-93-5p as a potential prognostic and predictive biomarker and
application of this molecule in the clinical practice is described.
Keywords:
hsa-miR-93-5p / kolorektalni karcinom / metastaza / odgovor na terapiju / prognostički biomarker / prediktivni biomarker / hsa-miR-93-5p / colorectal cancer / metastasis / response to therapy / prognostic biomarker / predictive biomarkerSource:
Trendovi u molekularnoj Biologiji, 2022, 2, 90-103Publisher:
- Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
Note:
- Posebno se zahvaljujem dr Aleksandri Nikolić na kritičkoj oceni ovog rada, kao i svim savetima i sugestijama za poboljšanje njegovog kvaliteta.
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CHAP AU - Despotović, Jovana PY - 2022 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1815 AB - Kolorektalni karcinom predstavlja heterogenu bolest koja zauzima treće i drugo mesto na svetu po stepenu incidence i stopi mortaliteta, respektivno. Poznato je da mikroRNK molekuli imaju ključne uloge u procesu patogeneze, progresije i metastaziranja kolorektalnog karcinoma, ali i rezistenciji na hemioterapiju. U različitim tumorima je pokazano da hsa-miR-93-5p može imati onkogenu, ali i tumor-supresorsku ulogu. Ovaj rad ima za cilj da predstavi dosadašnja saznanja o ulozi hsa-miR-93-5p u procesima vezanim za kolorektalnu karcinogenezu, metastaziranje i odgovor na hemioterapiju kod pacijenata sa kolorektalnim karcinomom. Rad takođe razmatra hsa-miR-93-5p kao potencijalni prognostički i prediktivni biomarker i primenu ovog molekula u kliničkoj praksi. AB - Colorectal cancer is a heterogeneous disease that ranks third and second globally in terms of incidence and mortality rates, respectively. MicroRNAs have been implicated in the growth, progression, metastasis and response to therapy of different tumors, including colorectal cancer. Hsa-miR-93-5p has been reported to have oncogenic and tumor-suppressive roles in different tumor kinds. This review article aims to present the current knowledge on the role of hsa-miR-93-5p in the processes related to colorectal carcinogenesis, metastasis and response to chemotherapy in patients with primary and metastatic colorectal cancer. Also, the role of hsa-miR-93-5p as a potential prognostic and predictive biomarker and application of this molecule in the clinical practice is described. PB - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo T2 - Trendovi u molekularnoj Biologiji T1 - Uloga hsa-miR-93-5p u kolorektalnom karcinomu T1 - Role of hsa-miR-93-5p in colorectal cancer EP - 103 IS - 2 SP - 90 UR - https://hdl.handle.net/21.15107/rcub_imagine_1815 ER -
@inbook{ author = "Despotović, Jovana", year = "2022", abstract = "Kolorektalni karcinom predstavlja heterogenu bolest koja zauzima treće i drugo mesto na svetu po stepenu incidence i stopi mortaliteta, respektivno. Poznato je da mikroRNK molekuli imaju ključne uloge u procesu patogeneze, progresije i metastaziranja kolorektalnog karcinoma, ali i rezistenciji na hemioterapiju. U različitim tumorima je pokazano da hsa-miR-93-5p može imati onkogenu, ali i tumor-supresorsku ulogu. Ovaj rad ima za cilj da predstavi dosadašnja saznanja o ulozi hsa-miR-93-5p u procesima vezanim za kolorektalnu karcinogenezu, metastaziranje i odgovor na hemioterapiju kod pacijenata sa kolorektalnim karcinomom. Rad takođe razmatra hsa-miR-93-5p kao potencijalni prognostički i prediktivni biomarker i primenu ovog molekula u kliničkoj praksi., Colorectal cancer is a heterogeneous disease that ranks third and second globally in terms of incidence and mortality rates, respectively. MicroRNAs have been implicated in the growth, progression, metastasis and response to therapy of different tumors, including colorectal cancer. Hsa-miR-93-5p has been reported to have oncogenic and tumor-suppressive roles in different tumor kinds. This review article aims to present the current knowledge on the role of hsa-miR-93-5p in the processes related to colorectal carcinogenesis, metastasis and response to chemotherapy in patients with primary and metastatic colorectal cancer. Also, the role of hsa-miR-93-5p as a potential prognostic and predictive biomarker and application of this molecule in the clinical practice is described.", publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo", journal = "Trendovi u molekularnoj Biologiji", booktitle = "Uloga hsa-miR-93-5p u kolorektalnom karcinomu, Role of hsa-miR-93-5p in colorectal cancer", pages = "103-90", number = "2", url = "https://hdl.handle.net/21.15107/rcub_imagine_1815" }
Despotović, J.. (2022). Uloga hsa-miR-93-5p u kolorektalnom karcinomu. in Trendovi u molekularnoj Biologiji Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 90-103. https://hdl.handle.net/21.15107/rcub_imagine_1815
Despotović J. Uloga hsa-miR-93-5p u kolorektalnom karcinomu. in Trendovi u molekularnoj Biologiji. 2022;(2):90-103. https://hdl.handle.net/21.15107/rcub_imagine_1815 .
Despotović, Jovana, "Uloga hsa-miR-93-5p u kolorektalnom karcinomu" in Trendovi u molekularnoj Biologiji, no. 2 (2022):90-103, https://hdl.handle.net/21.15107/rcub_imagine_1815 .