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Korelacija između Xmn l polimorfizma u ß-globinskom genskom lokusu l nivoa fetalnog hemoglobina u b-talasemičnih pacijenata u Srbiji / Correlation between XnmI ß-globin gene polymorphism and fetal hemoglobin level in ß-thalassemia patients in Serbia
(Društvo hematologa Srbije, Beograd, 2003)
Duž ß-globinskog genskog lokusa nalaze se polimorfna mesta koja predstavljaju sekvance koje seku određeni restrikcioni enzimi. Jednu od tih sekvenci prepoznaje XmnI restrikcioni enzim ( XmnI polimorfno mesto). Brojni podaci ...
TNF-alpha-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer
(Aepress Sro, Bratislava, 2009)
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are a major cause of morbidity and mortality worldwide. In both diseases airways inflammation plays an important role. Functional promoter polymorphism, at ...
Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis
(Elsevier, Amsterdam, 2007)
The BRCA2 tumor suppressor functions in repair of DNA by homologous recombination through regulating the action of Rad51. In turn, BRCA2 appears to be regulated by other interacting proteins. Dss1, a small interacting ...
ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells
(Springer, Dordrecht, 2009)
The aim of this study has been to identify transcription factors involved in transcriptional regulation of the human SOX18 gene expression. Structural analysis revealed that the SOX18 promoter lacks a TATA box, but is ...
Incidenca hiperhomocisteinemije i polimorfizam MTHFR C677T kod mladih bolesnika sa akutnim infarktom miokarda / Incidence of hyperhomocysteinemia and MTHFR C677T polymorphism among young patients with acute myocardial infarction
(Društvo medicinskih biohemičara Srbije, Beograd i Versita, 2009)
Hiperhomocisteinemija se smatra nezavisnim faktorom rizika za preuranjeni razvoj kardiovaskularnih bolesti. Mutacija MTHFR C677T snižava aktivnost metilentetra hidrofol atreduktaze i može dovesti do hiperhomocisteinemije. ...
DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA
(Amer Soc Biochemistry Molecular Biology Inc, Bethesda, 2009)
The C-terminal region of Brh2 (Brh2(CT)), the BRCA2 homolog in Ustilago maydis, is highly conserved and aligns with the DSS1/DNA-binding domain (DBD) of mammalian BRCA2, while the N-terminal region (Brh2(NT)) is poorly ...
Uticaj polimorfizma c.-1639g gt A VKORC1 gena na terapijski odgovor u toku primene oralnih antikoagulanasa / The c.-1639g gt A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use
(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2009)
Uvod/Cilj. Pojedinačni nukleotidni polimorfizam c.- 1639G gt A u promotorskom regionu gena za vitamin K epoksid- reduktazu (VKORC1), odgovoran je za varijabilnost odgovora u toku primene oralnih antikoagulanasa (OA). Cilj ...
The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products
(Macedonian Acad Sciences Arts, Skopje, 2009)
Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological ...
Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera / Retinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent
(Srpsko biološko društvo, Beograd, i dr., 2009)
Sox3/SOX3 gen je uključen u kontrolu razvića nervnog sistema. Naša prethodna istraživanja su pokazala da tokom neuralne indukcije NT2/D1 ćelija retinoičnom kiselinom (RK) dolazi do promene ekspresije humanog SOX3 gena. ...
Functional analysis of the buckwheat metallothionein promoter: Tissue specificity pattern and up-regulation under complex stress stimuli
(Elsevier Gmbh, Urban & Fischer Verlag, Jena, 2009)
To shed light on expression regulation of the metallothionein gene from buckwheat (FeMT3), functional promoter analysis was performed with a complete 5' regulatory region and two deletion variants, employing stably transformed ...