Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome
Authors
Drakulić, DanijelaRakonjac, Marijana
Cuturilo, Goran
Kovačević-Grujičić, Nataša
Kušić-Tišma, Jelena
Morić, Ivana
Zukić, Branka
Stevanović, Milena
Contributors
Morić, IvanaĐorđević, Valentina
Conference object (Published version)
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© 2023 Institute of Molecular Genetics and Genetic Engineering, University of Belgrade
Metadata
Show full item recordAbstract
22q11.2 deletion syndrome (22q11.2DS is caused by 22q11.2 microdeletion, one of
the strongest known risk factors for development of neurodevelopmental disorders.
About 70% patients with 22q11.2DS have speech and language impairments. In the
literature, there is no data about articulatory characteristics of phonemes of children
with 22q11.2DS, monolingual native speakers of South Slavic languages. Here we, by
applying Global Articulation Test, analyzed articulatory characteristics of phonemes of
children with 22q11.2DS, monolingual native speakers of the Serbian language (group
E1), children with a phenotype resembling 22q11.2DS but without the microdeletion
(group E2), children with non-syndromic congenital heart malformations (since children
with these malformations may exhibit a speech and language impairments) (group
E3) and their peers with typical speech-sound development (group C). Results of PCA
indicated that the groups can be distinguished based on the pronunciation... of phonemes,
and that the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩”
contributes the most to the variability between the groups. Results of AHP revealed that
the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩” was
rated the worst in the group E1. In conclusion, obtained results indicate that the presence
of 22q11.2 microdeletion influences articulation skills of carriers.
Keywords:
PCA / AHP / articulation / 22q11.2DSSource:
4th Belgrade Bioinformatics Conference, 2023, 4, 91-91Publisher:
- Belgrade : Institute of molecular genetics and genetic engineering
Funding / projects:
- This research was funded by European Union’s Horizon Europe programme (Grant Agreement Number 101060201 (STREAMLINE)),
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- Serbian Academy of Sciences and Arts (Grant number F-172)
Note:
- Book of abstract: 4th Belgrade Bioinformatics Conference, June 19-23, 2023
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Drakulić, Danijela AU - Rakonjac, Marijana AU - Cuturilo, Goran AU - Kovačević-Grujičić, Nataša AU - Kušić-Tišma, Jelena AU - Morić, Ivana AU - Zukić, Branka AU - Stevanović, Milena PY - 2023 UR - https://belbi.bg.ac.rs/ UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2036 AB - 22q11.2 deletion syndrome (22q11.2DS is caused by 22q11.2 microdeletion, one of the strongest known risk factors for development of neurodevelopmental disorders. About 70% patients with 22q11.2DS have speech and language impairments. In the literature, there is no data about articulatory characteristics of phonemes of children with 22q11.2DS, monolingual native speakers of South Slavic languages. Here we, by applying Global Articulation Test, analyzed articulatory characteristics of phonemes of children with 22q11.2DS, monolingual native speakers of the Serbian language (group E1), children with a phenotype resembling 22q11.2DS but without the microdeletion (group E2), children with non-syndromic congenital heart malformations (since children with these malformations may exhibit a speech and language impairments) (group E3) and their peers with typical speech-sound development (group C). Results of PCA indicated that the groups can be distinguished based on the pronunciation of phonemes, and that the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩” contributes the most to the variability between the groups. Results of AHP revealed that the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩” was rated the worst in the group E1. In conclusion, obtained results indicate that the presence of 22q11.2 microdeletion influences articulation skills of carriers. PB - Belgrade : Institute of molecular genetics and genetic engineering C3 - 4th Belgrade Bioinformatics Conference T1 - Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome EP - 91 SP - 91 VL - 4 UR - https://hdl.handle.net/21.15107/rcub_imagine_2036 ER -
@conference{ author = "Drakulić, Danijela and Rakonjac, Marijana and Cuturilo, Goran and Kovačević-Grujičić, Nataša and Kušić-Tišma, Jelena and Morić, Ivana and Zukić, Branka and Stevanović, Milena", year = "2023", abstract = "22q11.2 deletion syndrome (22q11.2DS is caused by 22q11.2 microdeletion, one of the strongest known risk factors for development of neurodevelopmental disorders. About 70% patients with 22q11.2DS have speech and language impairments. In the literature, there is no data about articulatory characteristics of phonemes of children with 22q11.2DS, monolingual native speakers of South Slavic languages. Here we, by applying Global Articulation Test, analyzed articulatory characteristics of phonemes of children with 22q11.2DS, monolingual native speakers of the Serbian language (group E1), children with a phenotype resembling 22q11.2DS but without the microdeletion (group E2), children with non-syndromic congenital heart malformations (since children with these malformations may exhibit a speech and language impairments) (group E3) and their peers with typical speech-sound development (group C). Results of PCA indicated that the groups can be distinguished based on the pronunciation of phonemes, and that the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩” contributes the most to the variability between the groups. Results of AHP revealed that the pronunciation of the phonemes “Č ⟨tʃ⟩”, “Dž ⟨ʤ⟩”, “Š ⟨∫⟩”, “Ž ⟨ʒ⟩”, “R”, and “Lj ⟨ʎ⟩” was rated the worst in the group E1. In conclusion, obtained results indicate that the presence of 22q11.2 microdeletion influences articulation skills of carriers.", publisher = "Belgrade : Institute of molecular genetics and genetic engineering", journal = "4th Belgrade Bioinformatics Conference", title = "Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome", pages = "91-91", volume = "4", url = "https://hdl.handle.net/21.15107/rcub_imagine_2036" }
Drakulić, D., Rakonjac, M., Cuturilo, G., Kovačević-Grujičić, N., Kušić-Tišma, J., Morić, I., Zukić, B.,& Stevanović, M.. (2023). Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome. in 4th Belgrade Bioinformatics Conference Belgrade : Institute of molecular genetics and genetic engineering., 4, 91-91. https://hdl.handle.net/21.15107/rcub_imagine_2036
Drakulić D, Rakonjac M, Cuturilo G, Kovačević-Grujičić N, Kušić-Tišma J, Morić I, Zukić B, Stevanović M. Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome. in 4th Belgrade Bioinformatics Conference. 2023;4:91-91. https://hdl.handle.net/21.15107/rcub_imagine_2036 .
Drakulić, Danijela, Rakonjac, Marijana, Cuturilo, Goran, Kovačević-Grujičić, Nataša, Kušić-Tišma, Jelena, Morić, Ivana, Zukić, Branka, Stevanović, Milena, "Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome" in 4th Belgrade Bioinformatics Conference, 4 (2023):91-91, https://hdl.handle.net/21.15107/rcub_imagine_2036 .