Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript
Samo za registrovane korisnike
2004
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Acquired amegakaryocytic thrombocytopenia (AATP) in adults is a rare disorder characterized by severe thrombocytopenia and decreased or absent megakaryocytes in an otherwise normal bone marrow. We present a 44-yr-old man in whom the diagnosis of AATP was established in January 2001. Immunophenotyping of the peripheral blood lymphocytes showed a relative increase in the subpopulation of gamma/delta T-cell receptor (TCR) positive (gamma/delta TCR+) and (CD4, CD8) negative T lymphocytes, and PCR suggested a monoclonal pattern of TCR gamma chain gene rearrangement. Cytogenetic examination of his bone marrow cells showed a normal male karyotype but RT-PCR analysis revealed a BCR-ABL (p210) fusion transcript. The inhibition of CFU-Mk growth mediated by the patient's T lymphocytes indicated that the pathogenic mechanism for AATP could be an immunological attack on megakaryocyte progenitors where the gamma/delta TCR-positive T lymphocytes are directly involved. The case emphasizes the complex ...association of T-lymphocyte monoclonal proliferation and AATP.
Ključne reči:
T-lymphocytes / gamma/delta TCR+ and BCR-ABL (p210) / acquired amegakaryocytic thrombocytopeniaIzvor:
European Journal of Haematology, 2004, 73, 5, 372-375Izdavač:
- Wiley, Hoboken
DOI: 10.1111/j.1600-0609.2004.00316.x
ISSN: 0902-4441
PubMed: 15458517
WoS: 000224241000009
Scopus: 2-s2.0-5344251613
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Colović, M AU - Pavlović, Sonja AU - Kraguljac, N AU - Čolović, Nataša AU - Janković, G AU - Sefer, D AU - Tošić, Nataša PY - 2004 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/205 AB - Acquired amegakaryocytic thrombocytopenia (AATP) in adults is a rare disorder characterized by severe thrombocytopenia and decreased or absent megakaryocytes in an otherwise normal bone marrow. We present a 44-yr-old man in whom the diagnosis of AATP was established in January 2001. Immunophenotyping of the peripheral blood lymphocytes showed a relative increase in the subpopulation of gamma/delta T-cell receptor (TCR) positive (gamma/delta TCR+) and (CD4, CD8) negative T lymphocytes, and PCR suggested a monoclonal pattern of TCR gamma chain gene rearrangement. Cytogenetic examination of his bone marrow cells showed a normal male karyotype but RT-PCR analysis revealed a BCR-ABL (p210) fusion transcript. The inhibition of CFU-Mk growth mediated by the patient's T lymphocytes indicated that the pathogenic mechanism for AATP could be an immunological attack on megakaryocyte progenitors where the gamma/delta TCR-positive T lymphocytes are directly involved. The case emphasizes the complex association of T-lymphocyte monoclonal proliferation and AATP. PB - Wiley, Hoboken T2 - European Journal of Haematology T1 - Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript EP - 375 IS - 5 SP - 372 VL - 73 DO - 10.1111/j.1600-0609.2004.00316.x ER -
@article{ author = "Colović, M and Pavlović, Sonja and Kraguljac, N and Čolović, Nataša and Janković, G and Sefer, D and Tošić, Nataša", year = "2004", abstract = "Acquired amegakaryocytic thrombocytopenia (AATP) in adults is a rare disorder characterized by severe thrombocytopenia and decreased or absent megakaryocytes in an otherwise normal bone marrow. We present a 44-yr-old man in whom the diagnosis of AATP was established in January 2001. Immunophenotyping of the peripheral blood lymphocytes showed a relative increase in the subpopulation of gamma/delta T-cell receptor (TCR) positive (gamma/delta TCR+) and (CD4, CD8) negative T lymphocytes, and PCR suggested a monoclonal pattern of TCR gamma chain gene rearrangement. Cytogenetic examination of his bone marrow cells showed a normal male karyotype but RT-PCR analysis revealed a BCR-ABL (p210) fusion transcript. The inhibition of CFU-Mk growth mediated by the patient's T lymphocytes indicated that the pathogenic mechanism for AATP could be an immunological attack on megakaryocyte progenitors where the gamma/delta TCR-positive T lymphocytes are directly involved. The case emphasizes the complex association of T-lymphocyte monoclonal proliferation and AATP.", publisher = "Wiley, Hoboken", journal = "European Journal of Haematology", title = "Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript", pages = "375-372", number = "5", volume = "73", doi = "10.1111/j.1600-0609.2004.00316.x" }
Colović, M., Pavlović, S., Kraguljac, N., Čolović, N., Janković, G., Sefer, D.,& Tošić, N.. (2004). Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript. in European Journal of Haematology Wiley, Hoboken., 73(5), 372-375. https://doi.org/10.1111/j.1600-0609.2004.00316.x
Colović M, Pavlović S, Kraguljac N, Čolović N, Janković G, Sefer D, Tošić N. Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript. in European Journal of Haematology. 2004;73(5):372-375. doi:10.1111/j.1600-0609.2004.00316.x .
Colović, M, Pavlović, Sonja, Kraguljac, N, Čolović, Nataša, Janković, G, Sefer, D, Tošić, Nataša, "Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript" in European Journal of Haematology, 73, no. 5 (2004):372-375, https://doi.org/10.1111/j.1600-0609.2004.00316.x . .