Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up
Samo za registrovane korisnike
2005
Autori
Antonijević, NebojšaStanojević, M
Milosević, R
Đorđević, Valentina
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Jauković, M
Vukcević, V
Kovač, Mirjana
![](/themes/Mirageimagine/images/orcid.png)
Miković, D
Radojković, Dragica
![](/themes/Mirageimagine/images/orcid.png)
Vasiljević, Z
Članak u časopisu (Objavljena verzija)
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We present the case of a 64 year-old female patient, with a clearly positive family history of venous thromboembolism (VTE), multiple VTE episodes (massive pulmonary embolism, ovarian venous plexus thrombosis, deep venous thrombosis with submassive pulmonary embolism and second deep venous thrombosis) and myocardial infarction. Laboratory tests revealed the resistance to the activated protein C, elevated FVIII and PAI-1. The patient was found to be a heterozygous carrier of FV Leiden, MTHFR C677T and PAI-1 4G/5G mutations. She was diagnosed with essential thrombocythemia at the age of 60. The thirty-three-year follow-up of our patient and detection of recurrent thrombotic episodes in the light of multiple coagulation defects with proved acquired risk factors, contributes to the risk stratification in the group of patients with very high risk. In case of our patient, we stress inadequacy of widely-accepted standard prevention measures. In our opinion, patients with very high risk requir...e additional mechanic and specific medicament methods of VTE prevention.
Ključne reči:
recurrent VTE / myocardial infarction / essential thrombocythemia / combined thrombophiliaIzvor:
Journal of Thrombosis and Thrombolysis, 2005, 19, 2, 93-95Izdavač:
- Springer, Dordrecht
DOI: 10.1007/s11239-005-0783-1
ISSN: 0929-5305
PubMed: 16052298
WoS: 000230909700003
Scopus: 2-s2.0-23644442050
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Antonijević, Nebojša AU - Stanojević, M AU - Milosević, R AU - Đorđević, Valentina AU - Jauković, M AU - Vukcević, V AU - Kovač, Mirjana AU - Miković, D AU - Radojković, Dragica AU - Vasiljević, Z PY - 2005 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/217 AB - We present the case of a 64 year-old female patient, with a clearly positive family history of venous thromboembolism (VTE), multiple VTE episodes (massive pulmonary embolism, ovarian venous plexus thrombosis, deep venous thrombosis with submassive pulmonary embolism and second deep venous thrombosis) and myocardial infarction. Laboratory tests revealed the resistance to the activated protein C, elevated FVIII and PAI-1. The patient was found to be a heterozygous carrier of FV Leiden, MTHFR C677T and PAI-1 4G/5G mutations. She was diagnosed with essential thrombocythemia at the age of 60. The thirty-three-year follow-up of our patient and detection of recurrent thrombotic episodes in the light of multiple coagulation defects with proved acquired risk factors, contributes to the risk stratification in the group of patients with very high risk. In case of our patient, we stress inadequacy of widely-accepted standard prevention measures. In our opinion, patients with very high risk require additional mechanic and specific medicament methods of VTE prevention. PB - Springer, Dordrecht T2 - Journal of Thrombosis and Thrombolysis T1 - Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up EP - 95 IS - 2 SP - 93 VL - 19 DO - 10.1007/s11239-005-0783-1 ER -
@article{ author = "Antonijević, Nebojša and Stanojević, M and Milosević, R and Đorđević, Valentina and Jauković, M and Vukcević, V and Kovač, Mirjana and Miković, D and Radojković, Dragica and Vasiljević, Z", year = "2005", abstract = "We present the case of a 64 year-old female patient, with a clearly positive family history of venous thromboembolism (VTE), multiple VTE episodes (massive pulmonary embolism, ovarian venous plexus thrombosis, deep venous thrombosis with submassive pulmonary embolism and second deep venous thrombosis) and myocardial infarction. Laboratory tests revealed the resistance to the activated protein C, elevated FVIII and PAI-1. The patient was found to be a heterozygous carrier of FV Leiden, MTHFR C677T and PAI-1 4G/5G mutations. She was diagnosed with essential thrombocythemia at the age of 60. The thirty-three-year follow-up of our patient and detection of recurrent thrombotic episodes in the light of multiple coagulation defects with proved acquired risk factors, contributes to the risk stratification in the group of patients with very high risk. In case of our patient, we stress inadequacy of widely-accepted standard prevention measures. In our opinion, patients with very high risk require additional mechanic and specific medicament methods of VTE prevention.", publisher = "Springer, Dordrecht", journal = "Journal of Thrombosis and Thrombolysis", title = "Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up", pages = "95-93", number = "2", volume = "19", doi = "10.1007/s11239-005-0783-1" }
Antonijević, N., Stanojević, M., Milosević, R., Đorđević, V., Jauković, M., Vukcević, V., Kovač, M., Miković, D., Radojković, D.,& Vasiljević, Z.. (2005). Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up. in Journal of Thrombosis and Thrombolysis Springer, Dordrecht., 19(2), 93-95. https://doi.org/10.1007/s11239-005-0783-1
Antonijević N, Stanojević M, Milosević R, Đorđević V, Jauković M, Vukcević V, Kovač M, Miković D, Radojković D, Vasiljević Z. Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up. in Journal of Thrombosis and Thrombolysis. 2005;19(2):93-95. doi:10.1007/s11239-005-0783-1 .
Antonijević, Nebojša, Stanojević, M, Milosević, R, Đorđević, Valentina, Jauković, M, Vukcević, V, Kovač, Mirjana, Miković, D, Radojković, Dragica, Vasiljević, Z, "Combined thrombophilic risk factors and essential thrombocythemia in patient with recurrent venous thromboembolic episodes - Thirty-three-year follow-up" in Journal of Thrombosis and Thrombolysis, 19, no. 2 (2005):93-95, https://doi.org/10.1007/s11239-005-0783-1 . .