The Microbiome-Gut-Brain Axis in Multiple Sclerosis
Mikrobiom-crevo-mozak osovina kod multiple skleroze
Authors
Radojević, DušanBajić, Svetlana Soković
Dinić, Miroslav
Bisenić, Aleksandar
Đokić, Jelena
Golić, Nataša
Article (Published version)
Metadata
Show full item recordAbstract
The microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can communicate with the CNS and modulate the physiology of the brain in health and disease, which marks them as an important MGBA factor. It is becoming increasingly evident that gut microbiome dysbiosis is implicated in the onset and severity of different neurodegenerative and psychiatric diseases including multiple sclerosis (MS). MS is a chronic disease of the CNS associated with different genetic and environmental risk factors. Neuroinflammation and demyelination in the brain and the spinal cord are hallmark features of MS. The accumulating evidence shows that the MGBA, although a relatively new concept, has an important role in MS. Therefore, the purpose of this article is to review recent resea...rch on the gut-brain connection in MS, and to highlight MS-associated gut microbiota constituents and the role of bacterial metabolites in MS.
Mikrobiom-crevo-mozak osovina (MGBA) predstavlja blisku dvosmernu vezu između creva i centralnog nervnog sistema (CNS) posredovanu imunskim sistemom, enteričnim nervnim sistemom (ENS), nervom vagusom i mikrobiomom creva. Posredstvom metabolita koje produkuju, mikroorganizmi creva, uključujući bakterije, gljive i viruse, komuniciraju sa CNS-om i tako utiču na funkcije mozga, zbog čega je mikrobiota creva prepoznata kao veoma važan faktor održavanja homeostaze MGBA. Takođe, veliki broj podataka ukazao je na povezanost disbioze mikrobioma creva i nastanka i težine simptoma različitih neurodegenerativnih i psihijatrijskih bolesti, uključujući multiplu sklerozu (MS), autoimunsku bolest nervnog sistema. MS je hronična bolest CNS-a povezana sa više genetskih faktora, kao i sa različitim sredinskim faktorima i životnim navikama. Najvažnija obeležja MS su neuroinflamacija i demijelinizacija u mozgu i kičmenoj moždini, a veliki broj istraživanja je ukazao i ...na specifične mikrobijalne markere ove bolesti. Cilj ovog rada je da pruži pregled najvažnijih podataka o povezanosti promena u sastavu i funkciji mikrobiote creva i patoloških promena karakterističnih za MS.
Keywords:
gut microbiome / multiple sclerosis / gut-brain axis / bacterial metabolites / dysbiosis / mikrobiom creva / multipla skleroza / crevo-mozak osovina / metaboliti bakterija / disbiozaSource:
Archives of Pharmacy, 2023, 73, Notebook 6, 441-462Publisher:
- Centre for Evaluation in Education and Science
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
- NextGenBiotics - The use of integrative multi-omics approach in cultivation and characterization of gut bacteria related to microbiota-gut-brain axis as a source for Next Generation Probiotics (RS-ScienceFundRS-Ideje-7744507)
URI
https://aseestant.ceon.rs/index.php/arhfarm/article/view/46986https://imagine.imgge.bg.ac.rs/handle/123456789/2294
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Radojević, Dušan AU - Bajić, Svetlana Soković AU - Dinić, Miroslav AU - Bisenić, Aleksandar AU - Đokić, Jelena AU - Golić, Nataša PY - 2023 UR - https://aseestant.ceon.rs/index.php/arhfarm/article/view/46986 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2294 AB - The microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can communicate with the CNS and modulate the physiology of the brain in health and disease, which marks them as an important MGBA factor. It is becoming increasingly evident that gut microbiome dysbiosis is implicated in the onset and severity of different neurodegenerative and psychiatric diseases including multiple sclerosis (MS). MS is a chronic disease of the CNS associated with different genetic and environmental risk factors. Neuroinflammation and demyelination in the brain and the spinal cord are hallmark features of MS. The accumulating evidence shows that the MGBA, although a relatively new concept, has an important role in MS. Therefore, the purpose of this article is to review recent research on the gut-brain connection in MS, and to highlight MS-associated gut microbiota constituents and the role of bacterial metabolites in MS. AB - Mikrobiom-crevo-mozak osovina (MGBA) predstavlja blisku dvosmernu vezu između creva i centralnog nervnog sistema (CNS) posredovanu imunskim sistemom, enteričnim nervnim sistemom (ENS), nervom vagusom i mikrobiomom creva. Posredstvom metabolita koje produkuju, mikroorganizmi creva, uključujući bakterije, gljive i viruse, komuniciraju sa CNS-om i tako utiču na funkcije mozga, zbog čega je mikrobiota creva prepoznata kao veoma važan faktor održavanja homeostaze MGBA. Takođe, veliki broj podataka ukazao je na povezanost disbioze mikrobioma creva i nastanka i težine simptoma različitih neurodegenerativnih i psihijatrijskih bolesti, uključujući multiplu sklerozu (MS), autoimunsku bolest nervnog sistema. MS je hronična bolest CNS-a povezana sa više genetskih faktora, kao i sa različitim sredinskim faktorima i životnim navikama. Najvažnija obeležja MS su neuroinflamacija i demijelinizacija u mozgu i kičmenoj moždini, a veliki broj istraživanja je ukazao i na specifične mikrobijalne markere ove bolesti. Cilj ovog rada je da pruži pregled najvažnijih podataka o povezanosti promena u sastavu i funkciji mikrobiote creva i patoloških promena karakterističnih za MS. PB - Centre for Evaluation in Education and Science T2 - Archives of Pharmacy T1 - The Microbiome-Gut-Brain Axis in Multiple Sclerosis T1 - Mikrobiom-crevo-mozak osovina kod multiple skleroze EP - 462 IS - Notebook 6 SP - 441 VL - 73 DO - 10.5937/arhfarm73-46986 ER -
@article{ author = "Radojević, Dušan and Bajić, Svetlana Soković and Dinić, Miroslav and Bisenić, Aleksandar and Đokić, Jelena and Golić, Nataša", year = "2023", abstract = "The microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can communicate with the CNS and modulate the physiology of the brain in health and disease, which marks them as an important MGBA factor. It is becoming increasingly evident that gut microbiome dysbiosis is implicated in the onset and severity of different neurodegenerative and psychiatric diseases including multiple sclerosis (MS). MS is a chronic disease of the CNS associated with different genetic and environmental risk factors. Neuroinflammation and demyelination in the brain and the spinal cord are hallmark features of MS. The accumulating evidence shows that the MGBA, although a relatively new concept, has an important role in MS. Therefore, the purpose of this article is to review recent research on the gut-brain connection in MS, and to highlight MS-associated gut microbiota constituents and the role of bacterial metabolites in MS., Mikrobiom-crevo-mozak osovina (MGBA) predstavlja blisku dvosmernu vezu između creva i centralnog nervnog sistema (CNS) posredovanu imunskim sistemom, enteričnim nervnim sistemom (ENS), nervom vagusom i mikrobiomom creva. Posredstvom metabolita koje produkuju, mikroorganizmi creva, uključujući bakterije, gljive i viruse, komuniciraju sa CNS-om i tako utiču na funkcije mozga, zbog čega je mikrobiota creva prepoznata kao veoma važan faktor održavanja homeostaze MGBA. Takođe, veliki broj podataka ukazao je na povezanost disbioze mikrobioma creva i nastanka i težine simptoma različitih neurodegenerativnih i psihijatrijskih bolesti, uključujući multiplu sklerozu (MS), autoimunsku bolest nervnog sistema. MS je hronična bolest CNS-a povezana sa više genetskih faktora, kao i sa različitim sredinskim faktorima i životnim navikama. Najvažnija obeležja MS su neuroinflamacija i demijelinizacija u mozgu i kičmenoj moždini, a veliki broj istraživanja je ukazao i na specifične mikrobijalne markere ove bolesti. Cilj ovog rada je da pruži pregled najvažnijih podataka o povezanosti promena u sastavu i funkciji mikrobiote creva i patoloških promena karakterističnih za MS.", publisher = "Centre for Evaluation in Education and Science", journal = "Archives of Pharmacy", title = "The Microbiome-Gut-Brain Axis in Multiple Sclerosis, Mikrobiom-crevo-mozak osovina kod multiple skleroze", pages = "462-441", number = "Notebook 6", volume = "73", doi = "10.5937/arhfarm73-46986" }
Radojević, D., Bajić, S. S., Dinić, M., Bisenić, A., Đokić, J.,& Golić, N.. (2023). The Microbiome-Gut-Brain Axis in Multiple Sclerosis. in Archives of Pharmacy Centre for Evaluation in Education and Science., 73(Notebook 6), 441-462. https://doi.org/10.5937/arhfarm73-46986
Radojević D, Bajić SS, Dinić M, Bisenić A, Đokić J, Golić N. The Microbiome-Gut-Brain Axis in Multiple Sclerosis. in Archives of Pharmacy. 2023;73(Notebook 6):441-462. doi:10.5937/arhfarm73-46986 .
Radojević, Dušan, Bajić, Svetlana Soković, Dinić, Miroslav, Bisenić, Aleksandar, Đokić, Jelena, Golić, Nataša, "The Microbiome-Gut-Brain Axis in Multiple Sclerosis" in Archives of Pharmacy, 73, no. Notebook 6 (2023):441-462, https://doi.org/10.5937/arhfarm73-46986 . .