The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells
Autori
Cumbo, MarijaDunjić-Manevski, Sofija
Gvozdenov, Maja
Mitić, Martina Mia
Đorđević, Valentina
Tomić, Branko
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Thrombotic disorders are some of the main comorbidities in cancer patients. So far, research has indicated that thrombin, a key regulator of hemostasis, contributes to cancer progression. However, data on its origin in tumor microenvironments remain elusive. Based on previous research, we analyzed the RNA and protein expression of prothrombin, a precursor of thrombin, in selected colorectal cancer (CRC) cell lines. Since the effect of prothrombin in cancer development has not been previously reported, we treated the cells for 24 h and 48 h with different prothrombin concentrations and assessed the effect on cell proliferation and migration. Our results show that the tested CRC cell lines expressed prothrombin and that prothrombin inhibited proliferation and migration. The presented results suggest that prothrombin may contribute to CRC etiopathology and could serve as a potential diagnostic biomarker and therapeutic target. The mechanisms underlying prothrombin expression in cancer cel...ls, potential prothrombin activation, and the underlying processes driving the described effects warrant further investigation.
Ključne reči:
prothrombin / cancer / protein expression / cell proliferation / cell migrationIzvor:
Archives of Biological Sciences, 2024, 76, 1, 111-120Izdavač:
- Serbian Biological Society, Institute for Biological Research "Siniša Stanković"
URI
https://doiserbia.nb.rs/Article.aspx?ID=0354-46642400007Chttps://imagine.imgge.bg.ac.rs/handle/123456789/2358
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Cumbo, Marija AU - Dunjić-Manevski, Sofija AU - Gvozdenov, Maja AU - Mitić, Martina Mia AU - Đorđević, Valentina AU - Tomić, Branko PY - 2024 UR - https://doiserbia.nb.rs/Article.aspx?ID=0354-46642400007C UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2358 AB - Thrombotic disorders are some of the main comorbidities in cancer patients. So far, research has indicated that thrombin, a key regulator of hemostasis, contributes to cancer progression. However, data on its origin in tumor microenvironments remain elusive. Based on previous research, we analyzed the RNA and protein expression of prothrombin, a precursor of thrombin, in selected colorectal cancer (CRC) cell lines. Since the effect of prothrombin in cancer development has not been previously reported, we treated the cells for 24 h and 48 h with different prothrombin concentrations and assessed the effect on cell proliferation and migration. Our results show that the tested CRC cell lines expressed prothrombin and that prothrombin inhibited proliferation and migration. The presented results suggest that prothrombin may contribute to CRC etiopathology and could serve as a potential diagnostic biomarker and therapeutic target. The mechanisms underlying prothrombin expression in cancer cells, potential prothrombin activation, and the underlying processes driving the described effects warrant further investigation. PB - Serbian Biological Society, Institute for Biological Research "Siniša Stanković" T2 - Archives of Biological Sciences T2 - Archives of Biological Sciences T1 - The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells EP - 120 IS - 1 SP - 111 VL - 76 UR - https://hdl.handle.net/21.15107/rcub_imagine_2358 ER -
@article{ author = "Cumbo, Marija and Dunjić-Manevski, Sofija and Gvozdenov, Maja and Mitić, Martina Mia and Đorđević, Valentina and Tomić, Branko", year = "2024", abstract = "Thrombotic disorders are some of the main comorbidities in cancer patients. So far, research has indicated that thrombin, a key regulator of hemostasis, contributes to cancer progression. However, data on its origin in tumor microenvironments remain elusive. Based on previous research, we analyzed the RNA and protein expression of prothrombin, a precursor of thrombin, in selected colorectal cancer (CRC) cell lines. Since the effect of prothrombin in cancer development has not been previously reported, we treated the cells for 24 h and 48 h with different prothrombin concentrations and assessed the effect on cell proliferation and migration. Our results show that the tested CRC cell lines expressed prothrombin and that prothrombin inhibited proliferation and migration. The presented results suggest that prothrombin may contribute to CRC etiopathology and could serve as a potential diagnostic biomarker and therapeutic target. The mechanisms underlying prothrombin expression in cancer cells, potential prothrombin activation, and the underlying processes driving the described effects warrant further investigation.", publisher = "Serbian Biological Society, Institute for Biological Research "Siniša Stanković"", journal = "Archives of Biological Sciences, Archives of Biological Sciences", title = "The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells", pages = "120-111", number = "1", volume = "76", url = "https://hdl.handle.net/21.15107/rcub_imagine_2358" }
Cumbo, M., Dunjić-Manevski, S., Gvozdenov, M., Mitić, M. M., Đorđević, V.,& Tomić, B.. (2024). The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells. in Archives of Biological Sciences Serbian Biological Society, Institute for Biological Research "Siniša Stanković"., 76(1), 111-120. https://hdl.handle.net/21.15107/rcub_imagine_2358
Cumbo M, Dunjić-Manevski S, Gvozdenov M, Mitić MM, Đorđević V, Tomić B. The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells. in Archives of Biological Sciences. 2024;76(1):111-120. https://hdl.handle.net/21.15107/rcub_imagine_2358 .
Cumbo, Marija, Dunjić-Manevski, Sofija, Gvozdenov, Maja, Mitić, Martina Mia, Đorđević, Valentina, Tomić, Branko, "The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells" in Archives of Biological Sciences, 76, no. 1 (2024):111-120, https://hdl.handle.net/21.15107/rcub_imagine_2358 .