A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research
Authors
Banićević, IvanaMilošević, Mia
Petrović, Jelena
Menshikh, Ksenia
Milivojević, Milena
Stevanović, Milena
Janković, Radmila
Cochis, Andrea
Bella, Elena Della
Stoddart, Martin
Rimondini, Lia
Stojkovska, Jasmina
Obradović, Bojana
Conference object (Published version)
Metadata
Show full item recordAbstract
Comprehensive research, particularly in evaluating drug efficacy, still heavily relies on the results obtained by the utilization of cell monolayers and animals. However, the inherent limitations of these models such as their physiological disparities from humans pose significant obstacles to acquiring reliable results thus impeding further scientific progression. To address this challenge, 3D in vitro cell culture models emerged as physiologically relevant models having the potential to enhance research and drug discovery. Our study aimed to develop a 3D in vitro cell culture model based on bone-like scaffolds in conjunction with a perfusion bioreactor (“3D Perfuse”, Innovation Center FTM, Belgrade, Serbia) for studying both physiological and pathological (i.e. tumors) bone conditions.
Keywords:
Alginate composite scaffolds / perfusion bioreactor / osteosarcoma / tumor engineering / mesenchymal stem cellsSource:
Hemijska industrija (Chemical Industry), 2024, 78, 1S, 19-19Funding / projects:
- Precision medicine for muscoloskeletal regeneration, prosthetics and active ageing (EU-H2020-860462)
- European Union’s Horizon 2020 Research and Innovation programme (GA Nos 952033)
URI
https://www.ache-pub.org.rs/index.php/HemInd/article/view/1261https://imagine.imgge.bg.ac.rs/handle/123456789/2363
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Banićević, Ivana AU - Milošević, Mia AU - Petrović, Jelena AU - Menshikh, Ksenia AU - Milivojević, Milena AU - Stevanović, Milena AU - Janković, Radmila AU - Cochis, Andrea AU - Bella, Elena Della AU - Stoddart, Martin AU - Rimondini, Lia AU - Stojkovska, Jasmina AU - Obradović, Bojana PY - 2024 UR - https://www.ache-pub.org.rs/index.php/HemInd/article/view/1261 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2363 AB - Comprehensive research, particularly in evaluating drug efficacy, still heavily relies on the results obtained by the utilization of cell monolayers and animals. However, the inherent limitations of these models such as their physiological disparities from humans pose significant obstacles to acquiring reliable results thus impeding further scientific progression. To address this challenge, 3D in vitro cell culture models emerged as physiologically relevant models having the potential to enhance research and drug discovery. Our study aimed to develop a 3D in vitro cell culture model based on bone-like scaffolds in conjunction with a perfusion bioreactor (“3D Perfuse”, Innovation Center FTM, Belgrade, Serbia) for studying both physiological and pathological (i.e. tumors) bone conditions. C3 - Hemijska industrija (Chemical Industry) T1 - A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research EP - 19 IS - 1S SP - 19 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_imagine_2363 ER -
@conference{ author = "Banićević, Ivana and Milošević, Mia and Petrović, Jelena and Menshikh, Ksenia and Milivojević, Milena and Stevanović, Milena and Janković, Radmila and Cochis, Andrea and Bella, Elena Della and Stoddart, Martin and Rimondini, Lia and Stojkovska, Jasmina and Obradović, Bojana", year = "2024", abstract = "Comprehensive research, particularly in evaluating drug efficacy, still heavily relies on the results obtained by the utilization of cell monolayers and animals. However, the inherent limitations of these models such as their physiological disparities from humans pose significant obstacles to acquiring reliable results thus impeding further scientific progression. To address this challenge, 3D in vitro cell culture models emerged as physiologically relevant models having the potential to enhance research and drug discovery. Our study aimed to develop a 3D in vitro cell culture model based on bone-like scaffolds in conjunction with a perfusion bioreactor (“3D Perfuse”, Innovation Center FTM, Belgrade, Serbia) for studying both physiological and pathological (i.e. tumors) bone conditions.", journal = "Hemijska industrija (Chemical Industry)", title = "A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research", pages = "19-19", number = "1S", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_imagine_2363" }
Banićević, I., Milošević, M., Petrović, J., Menshikh, K., Milivojević, M., Stevanović, M., Janković, R., Cochis, A., Bella, E. D., Stoddart, M., Rimondini, L., Stojkovska, J.,& Obradović, B.. (2024). A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research. in Hemijska industrija (Chemical Industry), 78(1S), 19-19. https://hdl.handle.net/21.15107/rcub_imagine_2363
Banićević I, Milošević M, Petrović J, Menshikh K, Milivojević M, Stevanović M, Janković R, Cochis A, Bella ED, Stoddart M, Rimondini L, Stojkovska J, Obradović B. A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research. in Hemijska industrija (Chemical Industry). 2024;78(1S):19-19. https://hdl.handle.net/21.15107/rcub_imagine_2363 .
Banićević, Ivana, Milošević, Mia, Petrović, Jelena, Menshikh, Ksenia, Milivojević, Milena, Stevanović, Milena, Janković, Radmila, Cochis, Andrea, Bella, Elena Della, Stoddart, Martin, Rimondini, Lia, Stojkovska, Jasmina, Obradović, Bojana, "A 3D in vitro cell culture model based on perfused bone-like scaffolds for healthy and pathological bone research" in Hemijska industrija (Chemical Industry), 78, no. 1S (2024):19-19, https://hdl.handle.net/21.15107/rcub_imagine_2363 .