FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS
Authors
Milivojević, DušanCerović, Bogdan
Nikodinović-Runić, Jasmina
Contributors
Dimkić, IvicaKekić, Dušan
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Caenorhabditis elegans is a free-living, non-parasitic,
fully transparent, bacteriovorous soil nematode.
Typically found in temperate climates, it
primarily inhabits organic-rich soil and decaying
fruit. Nearly six decades ago, Sydney Brenner
foresaw its potential as an ideal model system
for problems related developmental biology.
Over time, C. elegans has become instrumental
in investigations spanning aging, longevity,
host-pathogen interactions, developmental biology,
evolution, toxicology and ecotoxicology.
With more than 1200 research articles published
each year, today C. elegans is actively studied in
over a thousand laboratories worldwide. Despite
its small size, with adult hermaphrodites possessing
only 959 somatic cells and 302 neurons, C.
elegans exhibits a diverse array of specialized
tissues, including reproductive, digestive, endocrine,
neuromuscular, and sensory systems.
Moreover, this nematode shares a remarkable
number of conserved genes and signall...ing
pathways with humans, further enhancing its
relevance not only in biomedical research but
also in toxicology and ecotoxicology. In 1998, C.
elegans became the first multicellular organism
whose genome was completely sequenced. This
nematode is an excellent animal model for ecotoxicity
assessment because of its translucent
body, genetic manipulability, ease of cultivation,
rapid and short life cycle that is easily controlled
by temperature changes. The assessment endpoints
for the toxicology researches are various
and include number of live/dead worms, broad
size, number of eggs, embryo hatchability, locomotion
behaviours, germline apoptosis, oxidative
stress and gene expression in C. elegans. In
our laboratory, C. elegans is used in safety and ecotoxicological
evaluations of plastic degradation
products, artificial and natural materials, as well
as antimicrobial substances obtained through
the activity of specific microorganisms and their
chemical modification in the laboratory.
Keywords:
C. elegans / toxicology / environmental safetySource:
XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health, 2024, 173-173Publisher:
- Serbian Society for Microbiology
Note:
- Book of abstract: From biotechnology to human and planetary health XIII congress of microbiologists of Serbia with international participation Mikromed regio 5, ums series 24: 4th – 6th april 2024, Mona Plaza hotel, Belgrade, Serbia
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Milivojević, Dušan AU - Cerović, Bogdan AU - Nikodinović-Runić, Jasmina PY - 2024 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2384 AB - Caenorhabditis elegans is a free-living, non-parasitic, fully transparent, bacteriovorous soil nematode. Typically found in temperate climates, it primarily inhabits organic-rich soil and decaying fruit. Nearly six decades ago, Sydney Brenner foresaw its potential as an ideal model system for problems related developmental biology. Over time, C. elegans has become instrumental in investigations spanning aging, longevity, host-pathogen interactions, developmental biology, evolution, toxicology and ecotoxicology. With more than 1200 research articles published each year, today C. elegans is actively studied in over a thousand laboratories worldwide. Despite its small size, with adult hermaphrodites possessing only 959 somatic cells and 302 neurons, C. elegans exhibits a diverse array of specialized tissues, including reproductive, digestive, endocrine, neuromuscular, and sensory systems. Moreover, this nematode shares a remarkable number of conserved genes and signalling pathways with humans, further enhancing its relevance not only in biomedical research but also in toxicology and ecotoxicology. In 1998, C. elegans became the first multicellular organism whose genome was completely sequenced. This nematode is an excellent animal model for ecotoxicity assessment because of its translucent body, genetic manipulability, ease of cultivation, rapid and short life cycle that is easily controlled by temperature changes. The assessment endpoints for the toxicology researches are various and include number of live/dead worms, broad size, number of eggs, embryo hatchability, locomotion behaviours, germline apoptosis, oxidative stress and gene expression in C. elegans. In our laboratory, C. elegans is used in safety and ecotoxicological evaluations of plastic degradation products, artificial and natural materials, as well as antimicrobial substances obtained through the activity of specific microorganisms and their chemical modification in the laboratory. PB - Serbian Society for Microbiology C3 - XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health T1 - FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS EP - 173 SP - 173 UR - https://hdl.handle.net/21.15107/rcub_imagine_2384 ER -
@conference{ author = "Milivojević, Dušan and Cerović, Bogdan and Nikodinović-Runić, Jasmina", year = "2024", abstract = "Caenorhabditis elegans is a free-living, non-parasitic, fully transparent, bacteriovorous soil nematode. Typically found in temperate climates, it primarily inhabits organic-rich soil and decaying fruit. Nearly six decades ago, Sydney Brenner foresaw its potential as an ideal model system for problems related developmental biology. Over time, C. elegans has become instrumental in investigations spanning aging, longevity, host-pathogen interactions, developmental biology, evolution, toxicology and ecotoxicology. With more than 1200 research articles published each year, today C. elegans is actively studied in over a thousand laboratories worldwide. Despite its small size, with adult hermaphrodites possessing only 959 somatic cells and 302 neurons, C. elegans exhibits a diverse array of specialized tissues, including reproductive, digestive, endocrine, neuromuscular, and sensory systems. Moreover, this nematode shares a remarkable number of conserved genes and signalling pathways with humans, further enhancing its relevance not only in biomedical research but also in toxicology and ecotoxicology. In 1998, C. elegans became the first multicellular organism whose genome was completely sequenced. This nematode is an excellent animal model for ecotoxicity assessment because of its translucent body, genetic manipulability, ease of cultivation, rapid and short life cycle that is easily controlled by temperature changes. The assessment endpoints for the toxicology researches are various and include number of live/dead worms, broad size, number of eggs, embryo hatchability, locomotion behaviours, germline apoptosis, oxidative stress and gene expression in C. elegans. In our laboratory, C. elegans is used in safety and ecotoxicological evaluations of plastic degradation products, artificial and natural materials, as well as antimicrobial substances obtained through the activity of specific microorganisms and their chemical modification in the laboratory.", publisher = "Serbian Society for Microbiology", journal = "XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health", title = "FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS", pages = "173-173", url = "https://hdl.handle.net/21.15107/rcub_imagine_2384" }
Milivojević, D., Cerović, B.,& Nikodinović-Runić, J.. (2024). FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health Serbian Society for Microbiology., 173-173. https://hdl.handle.net/21.15107/rcub_imagine_2384
Milivojević D, Cerović B, Nikodinović-Runić J. FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health. 2024;:173-173. https://hdl.handle.net/21.15107/rcub_imagine_2384 .
Milivojević, Dušan, Cerović, Bogdan, Nikodinović-Runić, Jasmina, "FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS" in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health (2024):173-173, https://hdl.handle.net/21.15107/rcub_imagine_2384 .