Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment
Abstract
Alzheimer’s disease (AD), is the most common neurodegenerative disorder, sharing unclear
pathophysiology and massive social costs. Today, more than 55 million people have been diagnosed
with AD, and this number is forecast to increase more than twice by 2050. AD is tightly associated with
the presence of amyloid beta (Aβ) deposits, organised into insoluble, amyloid fibrils. Despite numerous
contemporary studies focused on the Aβ aggregation reduction, the cure for AD has not been found yet.
Our Project intends to implement the elements of molecular mechanisms underlying the remarkable
phenomenon of plant desiccation tolerance and develop a new Aβ anti-aggregation strategy. Late
Embryogenesis Abundant proteins (LEAPs) are markedly induced upon desiccation and can stabilise the
native structure of proteins and membranes by a mechanism that is not fully understood.
The primary Project aim is to investigate the structural properties of Ramonda serbica LEAPs and their
interactions... with Aβ. Firstly, we will recombinantly produce LEAPs with the highest potential to inhibit
Aβ aggregation. Further, we will analyse LEAPs’ secondary structure under different conditions, focusing
on their order-to-disorder transitions. The final aim is to identify Aβ/LEAPs interactions and assess the
Aβ anti-aggregation potential of LEAPs in vitro, which will have an impact on developing new strategies
for AD treatment. Moreover, the results of our project will be important for cryopreservation,
biotechnology, plant physiology, and agriculture. The partner groups involved in this project (Slovak: IEP
SAS) and Serbian: IMGGE) were selected based on their expertise in protein production and structure
analysis. The expertise transfer between partner laboratories will be ensured by mutual training of the
involved PhD and postdoc researchers.
Source:
Ministry of Science, Technological Development and Innovation of the Republic of Serbia, 2024Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, Program of bilateral scientific and technological cooperation between Republic of Serbia and the Slovak Republic, 2024-2026
Note:
- Principal Investigator: Dr Marija Vidović, IMGGE
- Duration period: 2024-2026
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - GEN PY - 2024 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2393 AB - Alzheimer’s disease (AD), is the most common neurodegenerative disorder, sharing unclear pathophysiology and massive social costs. Today, more than 55 million people have been diagnosed with AD, and this number is forecast to increase more than twice by 2050. AD is tightly associated with the presence of amyloid beta (Aβ) deposits, organised into insoluble, amyloid fibrils. Despite numerous contemporary studies focused on the Aβ aggregation reduction, the cure for AD has not been found yet. Our Project intends to implement the elements of molecular mechanisms underlying the remarkable phenomenon of plant desiccation tolerance and develop a new Aβ anti-aggregation strategy. Late Embryogenesis Abundant proteins (LEAPs) are markedly induced upon desiccation and can stabilise the native structure of proteins and membranes by a mechanism that is not fully understood. The primary Project aim is to investigate the structural properties of Ramonda serbica LEAPs and their interactions with Aβ. Firstly, we will recombinantly produce LEAPs with the highest potential to inhibit Aβ aggregation. Further, we will analyse LEAPs’ secondary structure under different conditions, focusing on their order-to-disorder transitions. The final aim is to identify Aβ/LEAPs interactions and assess the Aβ anti-aggregation potential of LEAPs in vitro, which will have an impact on developing new strategies for AD treatment. Moreover, the results of our project will be important for cryopreservation, biotechnology, plant physiology, and agriculture. The partner groups involved in this project (Slovak: IEP SAS) and Serbian: IMGGE) were selected based on their expertise in protein production and structure analysis. The expertise transfer between partner laboratories will be ensured by mutual training of the involved PhD and postdoc researchers. T2 - Ministry of Science, Technological Development and Innovation of the Republic of Serbia T1 - Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment UR - https://hdl.handle.net/21.15107/rcub_imagine_2393 ER -
@misc{ year = "2024", abstract = "Alzheimer’s disease (AD), is the most common neurodegenerative disorder, sharing unclear pathophysiology and massive social costs. Today, more than 55 million people have been diagnosed with AD, and this number is forecast to increase more than twice by 2050. AD is tightly associated with the presence of amyloid beta (Aβ) deposits, organised into insoluble, amyloid fibrils. Despite numerous contemporary studies focused on the Aβ aggregation reduction, the cure for AD has not been found yet. Our Project intends to implement the elements of molecular mechanisms underlying the remarkable phenomenon of plant desiccation tolerance and develop a new Aβ anti-aggregation strategy. Late Embryogenesis Abundant proteins (LEAPs) are markedly induced upon desiccation and can stabilise the native structure of proteins and membranes by a mechanism that is not fully understood. The primary Project aim is to investigate the structural properties of Ramonda serbica LEAPs and their interactions with Aβ. Firstly, we will recombinantly produce LEAPs with the highest potential to inhibit Aβ aggregation. Further, we will analyse LEAPs’ secondary structure under different conditions, focusing on their order-to-disorder transitions. The final aim is to identify Aβ/LEAPs interactions and assess the Aβ anti-aggregation potential of LEAPs in vitro, which will have an impact on developing new strategies for AD treatment. Moreover, the results of our project will be important for cryopreservation, biotechnology, plant physiology, and agriculture. The partner groups involved in this project (Slovak: IEP SAS) and Serbian: IMGGE) were selected based on their expertise in protein production and structure analysis. The expertise transfer between partner laboratories will be ensured by mutual training of the involved PhD and postdoc researchers.", journal = "Ministry of Science, Technological Development and Innovation of the Republic of Serbia", title = "Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment", url = "https://hdl.handle.net/21.15107/rcub_imagine_2393" }
(2024). Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment. in Ministry of Science, Technological Development and Innovation of the Republic of Serbia. https://hdl.handle.net/21.15107/rcub_imagine_2393
Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment. in Ministry of Science, Technological Development and Innovation of the Republic of Serbia. 2024;. https://hdl.handle.net/21.15107/rcub_imagine_2393 .
"Inhibition of Aβ Peptide Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment" in Ministry of Science, Technological Development and Innovation of the Republic of Serbia (2024), https://hdl.handle.net/21.15107/rcub_imagine_2393 .