Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19
Autori
Laban-Lazović, MarijaZečević, Marko
Kotur, Nikola
Gašić, Vladimir
Ristivojević, Bojan
Škodrić-Trifunović, Vesna
Adžić-Vukićević, Tatjana
Zukić, Branka
Pavlović, Sonja
Stanković, Biljana
Ostala autorstva
Morić, IvanaĐorđević, Valentina
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
acute phase of a SARS-CoV-2 infection. It can affect individuals who had both severe and mild
cases of COVID-19. The genetic predisposition to this condition remains largely unexplored.
This study aimed to identify genomic loci associated with Long COVID-19. The study included
92 patients with confirmed infection with SARS-CoV-2 during the delta variant wave and
treated in hospital settings. These patients were monitored for up to six months after the
acute infection. All patients were genotyped using the Illumina Infinium global screening
array, which covers over 700,000 genomic variants. Imputation was employed to expand
the number of variants to 12,001,939 using the 1kGP Phase 3 human reference panels.
We conducted a genome-wide association analysis using an in-house built pipeline on the
Cancer Genomic Cloud platform.
Our results identified association signals in the 20p11.21 genomic locus, with the lead variant
being rs1275745396 (p = 6.181x10-8), located within cystati...n genes (CST3, CST4, CST1).
The cystatin family consists of cysteine protease inhibitors, involved in various physiological
processes. Previous literature has linked serum and saliva cystatin levels to COVID-19 severity
and outcomes. Moreover, cystatin’s role in taste perception has been recognized previously,
which is in line with the well-known perturbations in sensory perception caused by COVID-19.
This study is the first to find a genetic association between cystatin genes and Long COVID-19.
Further research is necessary to elucidate the role of the cystatin protein family and the
biological processes underlying Long COVID-19. A deeper understanding of Long COVID-19
can inform the development of preventive and therapeutic strategies.
Ključne reči:
GWAS / Long COVID-19 / cystatinsIzvor:
5th Belgrade Bioinformatics Conference, 2024, 106-106Izdavač:
- Belgrade : Institute of Molecular Genetics and Genetic Engineering
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200042 (Univerzitet u Beogradu, Institut za molekularnu genetiku i genetičko inženjerstvo) (RS-MESTD-inst-2020-200042)
- Computational resources were provided by The Cancer Genomics Cloud, powered by Seven Bridges, a component of the NCI Cancer Research Data Commons (datacommons. cancer.gov), funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN261201400008C and ID/IQ Agreement No. 17X146 under Contract No. HHSN261201500003I and 75N91019D00024.
Napomena:
- Book of abstracts: 5th Belgrade Bioinformatics Conference, Serbia, Belgrade,17-20 june 2024.
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Laban-Lazović, Marija AU - Zečević, Marko AU - Kotur, Nikola AU - Gašić, Vladimir AU - Ristivojević, Bojan AU - Škodrić-Trifunović, Vesna AU - Adžić-Vukićević, Tatjana AU - Zukić, Branka AU - Pavlović, Sonja AU - Stanković, Biljana PY - 2024 UR - www.belbi.bg.ac.rs UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2466 AB - acute phase of a SARS-CoV-2 infection. It can affect individuals who had both severe and mild cases of COVID-19. The genetic predisposition to this condition remains largely unexplored. This study aimed to identify genomic loci associated with Long COVID-19. The study included 92 patients with confirmed infection with SARS-CoV-2 during the delta variant wave and treated in hospital settings. These patients were monitored for up to six months after the acute infection. All patients were genotyped using the Illumina Infinium global screening array, which covers over 700,000 genomic variants. Imputation was employed to expand the number of variants to 12,001,939 using the 1kGP Phase 3 human reference panels. We conducted a genome-wide association analysis using an in-house built pipeline on the Cancer Genomic Cloud platform. Our results identified association signals in the 20p11.21 genomic locus, with the lead variant being rs1275745396 (p = 6.181x10-8), located within cystatin genes (CST3, CST4, CST1). The cystatin family consists of cysteine protease inhibitors, involved in various physiological processes. Previous literature has linked serum and saliva cystatin levels to COVID-19 severity and outcomes. Moreover, cystatin’s role in taste perception has been recognized previously, which is in line with the well-known perturbations in sensory perception caused by COVID-19. This study is the first to find a genetic association between cystatin genes and Long COVID-19. Further research is necessary to elucidate the role of the cystatin protein family and the biological processes underlying Long COVID-19. A deeper understanding of Long COVID-19 can inform the development of preventive and therapeutic strategies. PB - Belgrade : Institute of Molecular Genetics and Genetic Engineering C3 - 5th Belgrade Bioinformatics Conference T1 - Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19 EP - 106 SP - 106 UR - https://hdl.handle.net/21.15107/rcub_imagine_2466 ER -
@conference{ author = "Laban-Lazović, Marija and Zečević, Marko and Kotur, Nikola and Gašić, Vladimir and Ristivojević, Bojan and Škodrić-Trifunović, Vesna and Adžić-Vukićević, Tatjana and Zukić, Branka and Pavlović, Sonja and Stanković, Biljana", year = "2024", abstract = "acute phase of a SARS-CoV-2 infection. It can affect individuals who had both severe and mild cases of COVID-19. The genetic predisposition to this condition remains largely unexplored. This study aimed to identify genomic loci associated with Long COVID-19. The study included 92 patients with confirmed infection with SARS-CoV-2 during the delta variant wave and treated in hospital settings. These patients were monitored for up to six months after the acute infection. All patients were genotyped using the Illumina Infinium global screening array, which covers over 700,000 genomic variants. Imputation was employed to expand the number of variants to 12,001,939 using the 1kGP Phase 3 human reference panels. We conducted a genome-wide association analysis using an in-house built pipeline on the Cancer Genomic Cloud platform. Our results identified association signals in the 20p11.21 genomic locus, with the lead variant being rs1275745396 (p = 6.181x10-8), located within cystatin genes (CST3, CST4, CST1). The cystatin family consists of cysteine protease inhibitors, involved in various physiological processes. Previous literature has linked serum and saliva cystatin levels to COVID-19 severity and outcomes. Moreover, cystatin’s role in taste perception has been recognized previously, which is in line with the well-known perturbations in sensory perception caused by COVID-19. This study is the first to find a genetic association between cystatin genes and Long COVID-19. Further research is necessary to elucidate the role of the cystatin protein family and the biological processes underlying Long COVID-19. A deeper understanding of Long COVID-19 can inform the development of preventive and therapeutic strategies.", publisher = "Belgrade : Institute of Molecular Genetics and Genetic Engineering", journal = "5th Belgrade Bioinformatics Conference", title = "Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19", pages = "106-106", url = "https://hdl.handle.net/21.15107/rcub_imagine_2466" }
Laban-Lazović, M., Zečević, M., Kotur, N., Gašić, V., Ristivojević, B., Škodrić-Trifunović, V., Adžić-Vukićević, T., Zukić, B., Pavlović, S.,& Stanković, B.. (2024). Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19. in 5th Belgrade Bioinformatics Conference Belgrade : Institute of Molecular Genetics and Genetic Engineering., 106-106. https://hdl.handle.net/21.15107/rcub_imagine_2466
Laban-Lazović M, Zečević M, Kotur N, Gašić V, Ristivojević B, Škodrić-Trifunović V, Adžić-Vukićević T, Zukić B, Pavlović S, Stanković B. Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19. in 5th Belgrade Bioinformatics Conference. 2024;:106-106. https://hdl.handle.net/21.15107/rcub_imagine_2466 .
Laban-Lazović, Marija, Zečević, Marko, Kotur, Nikola, Gašić, Vladimir, Ristivojević, Bojan, Škodrić-Trifunović, Vesna, Adžić-Vukićević, Tatjana, Zukić, Branka, Pavlović, Sonja, Stanković, Biljana, "Genome-wide association study identified genetic signal in cystatin genes associated with Long COVID-19" in 5th Belgrade Bioinformatics Conference (2024):106-106, https://hdl.handle.net/21.15107/rcub_imagine_2466 .