Pattern of trisomy 1q in hematological malignancies: a single institution experience
Само за регистроване кориснике
2008
Аутори
Đorđević, VesnaDenčić-Fekete, Marija
Jovanović, Jelica
Drakulić, Danijela
Stevanović, Milena
Janković, Gradimir
Gotić, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
An extra copy of 1q usually originates from the translocated unbalanced derivative chromosome, isochromosome, or "jumping translocation." We report a pattern of partial trisomies and unbalanced whole-arm translocations of 1q in 10 patients: 5 with myelodysplastic syndrome, 3 with acute myeloid leukemia, and a single patient with acute lymphoblastic leukemia and myeloproliferative syndrome. The trisomy of 1q was registered as the sole karyotype aberration in one patient, while it was accompanied by a limited number of additional chromosomal changes in nine patients. These patients are a subset of a larger group of 92 adults carrying a wide variety of chromosome 1 anomalies within a complex cytogenetic context observed over a period between 1994 and 2006 in a panel of 3,786 hematologic patients at the Institute of Hematology in Belgrade. Conventional cytogenetics was supplemented by fluorescence in situ hybridization with a probe specific for the paracentric region of 1q. Whole-arm 1q tr...anslocations involved chromosomes Y, 7, 14, 15, 16, and 19. This study suggests that gain of 1q as the sole cytogenetic abnormality may be sufficiently mutagenic to favor leukemogenesis and hematopoietic tissue degeneration (trilineage myelodysplasia).
Извор:
Cancer Genetics and Cytogenetics, 2008, 186, 1, 12-18Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Изучавање регулације експресије и функције хуманих SOX гена (RS-MESTD-MPN2006-2010-143028)
- Молекуларно генетски маркери клонског преображаја матичних ћелија хематопоезе (RS-MESTD-MPN2006-2010-145061)
DOI: 10.1016/j.cancergencyto.2008.05.003
ISSN: 0165-4608
PubMed: 18786437
WoS: 000260039000003
Scopus: 2-s2.0-51249121800
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Đorđević, Vesna AU - Denčić-Fekete, Marija AU - Jovanović, Jelica AU - Drakulić, Danijela AU - Stevanović, Milena AU - Janković, Gradimir AU - Gotić, Mirjana PY - 2008 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/322 AB - An extra copy of 1q usually originates from the translocated unbalanced derivative chromosome, isochromosome, or "jumping translocation." We report a pattern of partial trisomies and unbalanced whole-arm translocations of 1q in 10 patients: 5 with myelodysplastic syndrome, 3 with acute myeloid leukemia, and a single patient with acute lymphoblastic leukemia and myeloproliferative syndrome. The trisomy of 1q was registered as the sole karyotype aberration in one patient, while it was accompanied by a limited number of additional chromosomal changes in nine patients. These patients are a subset of a larger group of 92 adults carrying a wide variety of chromosome 1 anomalies within a complex cytogenetic context observed over a period between 1994 and 2006 in a panel of 3,786 hematologic patients at the Institute of Hematology in Belgrade. Conventional cytogenetics was supplemented by fluorescence in situ hybridization with a probe specific for the paracentric region of 1q. Whole-arm 1q translocations involved chromosomes Y, 7, 14, 15, 16, and 19. This study suggests that gain of 1q as the sole cytogenetic abnormality may be sufficiently mutagenic to favor leukemogenesis and hematopoietic tissue degeneration (trilineage myelodysplasia). PB - Elsevier Science Inc, New York T2 - Cancer Genetics and Cytogenetics T1 - Pattern of trisomy 1q in hematological malignancies: a single institution experience EP - 18 IS - 1 SP - 12 VL - 186 DO - 10.1016/j.cancergencyto.2008.05.003 ER -
@article{ author = "Đorđević, Vesna and Denčić-Fekete, Marija and Jovanović, Jelica and Drakulić, Danijela and Stevanović, Milena and Janković, Gradimir and Gotić, Mirjana", year = "2008", abstract = "An extra copy of 1q usually originates from the translocated unbalanced derivative chromosome, isochromosome, or "jumping translocation." We report a pattern of partial trisomies and unbalanced whole-arm translocations of 1q in 10 patients: 5 with myelodysplastic syndrome, 3 with acute myeloid leukemia, and a single patient with acute lymphoblastic leukemia and myeloproliferative syndrome. The trisomy of 1q was registered as the sole karyotype aberration in one patient, while it was accompanied by a limited number of additional chromosomal changes in nine patients. These patients are a subset of a larger group of 92 adults carrying a wide variety of chromosome 1 anomalies within a complex cytogenetic context observed over a period between 1994 and 2006 in a panel of 3,786 hematologic patients at the Institute of Hematology in Belgrade. Conventional cytogenetics was supplemented by fluorescence in situ hybridization with a probe specific for the paracentric region of 1q. Whole-arm 1q translocations involved chromosomes Y, 7, 14, 15, 16, and 19. This study suggests that gain of 1q as the sole cytogenetic abnormality may be sufficiently mutagenic to favor leukemogenesis and hematopoietic tissue degeneration (trilineage myelodysplasia).", publisher = "Elsevier Science Inc, New York", journal = "Cancer Genetics and Cytogenetics", title = "Pattern of trisomy 1q in hematological malignancies: a single institution experience", pages = "18-12", number = "1", volume = "186", doi = "10.1016/j.cancergencyto.2008.05.003" }
Đorđević, V., Denčić-Fekete, M., Jovanović, J., Drakulić, D., Stevanović, M., Janković, G.,& Gotić, M.. (2008). Pattern of trisomy 1q in hematological malignancies: a single institution experience. in Cancer Genetics and Cytogenetics Elsevier Science Inc, New York., 186(1), 12-18. https://doi.org/10.1016/j.cancergencyto.2008.05.003
Đorđević V, Denčić-Fekete M, Jovanović J, Drakulić D, Stevanović M, Janković G, Gotić M. Pattern of trisomy 1q in hematological malignancies: a single institution experience. in Cancer Genetics and Cytogenetics. 2008;186(1):12-18. doi:10.1016/j.cancergencyto.2008.05.003 .
Đorđević, Vesna, Denčić-Fekete, Marija, Jovanović, Jelica, Drakulić, Danijela, Stevanović, Milena, Janković, Gradimir, Gotić, Mirjana, "Pattern of trisomy 1q in hematological malignancies: a single institution experience" in Cancer Genetics and Cytogenetics, 186, no. 1 (2008):12-18, https://doi.org/10.1016/j.cancergencyto.2008.05.003 . .