GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality
Samo za registrovane korisnike
2008
Autori
Kwakowsky, AndreaSchwirtlich, Marija
Kooy, Frank
Abraham, Istvan
Mate, Zoltan
Katarova, Zoya
Szabo, Gabor
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the vertebrate nervous system, serves as a signaling molecule modulating diverse processes during embryonic development. Earlier we have demonstrated that different forms of glutamic acid decarboxylase (GAD) are differentially regulated during mouse lens development. Here we show that the developing lens expresses also components of GABA signaling downstream of GAD. Multiple GAB(A) and GABA(B) receptor subunits as well as the GABA transporters show expression profiles highly correlated with the expression of different GADS. GABA receptors (GABAR) and the vesicular GABA transporter localize at the apical/basal membranes of the lens epithelia and differentiating fibers and may be involved in conventional GABAR-mediated signaling, while the membrane GABA transporters may also function as Na+/Cl-/GABA carriers. The functionality of GABAR was verified by calcium imaging in whole lenses. Our data suggest that GABA synth...esized locally by GAD, acts through GABA receptors by modulating the intracellular calcium levels. Developmental Dynamics 237:3830-3841, 2008.
Ključne reči:
vesicular GABA transporter (VGAT) / non-neuronal GABA / membrane GABA transporters (GAT1-4) / lens development / intracellular calcium / GAD / GABA(B) receptor subunits / GABA(A) receptor subunitsIzvor:
Developmental Dynamics, 2008, 237, 12, 3830-3841Izdavač:
- Wiley, Hoboken
DOI: 10.1002/dvdy.21768
ISSN: 1058-8388
PubMed: 18985723
WoS: 000261679300034
Scopus: 2-s2.0-57149086087
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kwakowsky, Andrea AU - Schwirtlich, Marija AU - Kooy, Frank AU - Abraham, Istvan AU - Mate, Zoltan AU - Katarova, Zoya AU - Szabo, Gabor PY - 2008 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/326 AB - Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the vertebrate nervous system, serves as a signaling molecule modulating diverse processes during embryonic development. Earlier we have demonstrated that different forms of glutamic acid decarboxylase (GAD) are differentially regulated during mouse lens development. Here we show that the developing lens expresses also components of GABA signaling downstream of GAD. Multiple GAB(A) and GABA(B) receptor subunits as well as the GABA transporters show expression profiles highly correlated with the expression of different GADS. GABA receptors (GABAR) and the vesicular GABA transporter localize at the apical/basal membranes of the lens epithelia and differentiating fibers and may be involved in conventional GABAR-mediated signaling, while the membrane GABA transporters may also function as Na+/Cl-/GABA carriers. The functionality of GABAR was verified by calcium imaging in whole lenses. Our data suggest that GABA synthesized locally by GAD, acts through GABA receptors by modulating the intracellular calcium levels. Developmental Dynamics 237:3830-3841, 2008. PB - Wiley, Hoboken T2 - Developmental Dynamics T1 - GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality EP - 3841 IS - 12 SP - 3830 VL - 237 DO - 10.1002/dvdy.21768 ER -
@article{ author = "Kwakowsky, Andrea and Schwirtlich, Marija and Kooy, Frank and Abraham, Istvan and Mate, Zoltan and Katarova, Zoya and Szabo, Gabor", year = "2008", abstract = "Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the vertebrate nervous system, serves as a signaling molecule modulating diverse processes during embryonic development. Earlier we have demonstrated that different forms of glutamic acid decarboxylase (GAD) are differentially regulated during mouse lens development. Here we show that the developing lens expresses also components of GABA signaling downstream of GAD. Multiple GAB(A) and GABA(B) receptor subunits as well as the GABA transporters show expression profiles highly correlated with the expression of different GADS. GABA receptors (GABAR) and the vesicular GABA transporter localize at the apical/basal membranes of the lens epithelia and differentiating fibers and may be involved in conventional GABAR-mediated signaling, while the membrane GABA transporters may also function as Na+/Cl-/GABA carriers. The functionality of GABAR was verified by calcium imaging in whole lenses. Our data suggest that GABA synthesized locally by GAD, acts through GABA receptors by modulating the intracellular calcium levels. Developmental Dynamics 237:3830-3841, 2008.", publisher = "Wiley, Hoboken", journal = "Developmental Dynamics", title = "GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality", pages = "3841-3830", number = "12", volume = "237", doi = "10.1002/dvdy.21768" }
Kwakowsky, A., Schwirtlich, M., Kooy, F., Abraham, I., Mate, Z., Katarova, Z.,& Szabo, G.. (2008). GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality. in Developmental Dynamics Wiley, Hoboken., 237(12), 3830-3841. https://doi.org/10.1002/dvdy.21768
Kwakowsky A, Schwirtlich M, Kooy F, Abraham I, Mate Z, Katarova Z, Szabo G. GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality. in Developmental Dynamics. 2008;237(12):3830-3841. doi:10.1002/dvdy.21768 .
Kwakowsky, Andrea, Schwirtlich, Marija, Kooy, Frank, Abraham, Istvan, Mate, Zoltan, Katarova, Zoya, Szabo, Gabor, "GABA Neurotransmitter Signaling in the Developing Mouse Lens: Dynamic Regulation of Components and Functionality" in Developmental Dynamics, 237, no. 12 (2008):3830-3841, https://doi.org/10.1002/dvdy.21768 . .