Toxicity of oral cadmium intake: Impact on gut immunity
Samo za registrovane korisnike
2015
Autori
Ninkov, Marina![](/themes/Mirageimagine/images/orcid.png)
Popov Aleksandrov, Aleksandra
![](/themes/Mirageimagine/images/orcid.png)
Demenesku, Jelena
Mirkov, Ivana
![](/themes/Mirageimagine/images/orcid.png)
Mileusnić, Dina
![](/themes/Mirageimagine/images/orcid.png)
Petrović, Anja
![](/themes/Mirageimagine/images/orcid.png)
Grigorov, Ilijana
![](/themes/Mirageimagine/images/orcid.png)
Zolotarevski, Lidija
Tolinački, Maja
![](/themes/Mirageimagine/images/orcid.png)
Kataranovski, Dragan
Brceski, Ilija
![](/themes/Mirageimagine/images/orcid.png)
Kataranovski, Milena
![](/themes/Mirageimagine/images/orcid.png)
Članak u časopisu (Objavljena verzija)
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast ...to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor.
Ključne reči:
Rats / Oral cadmium intake / Mesenteric lymph nodes immune priming / Intestinal (duodenum) inflammationIzvor:
Toxicology Letters, 2015, 237, 2, 89-99Izdavač:
- Elsevier Ireland Ltd, Clare
Finansiranje / projekti:
- Imunomodulatorni efekti ksenobiotika i biotičkih faktora životne sredine na populacije mišolikih glodara (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.toxlet.2015.06.002
ISSN: 0378-4274
PubMed: 26051590
WoS: 000357391500004
Scopus: 2-s2.0-84931264431
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Ninkov, Marina AU - Popov Aleksandrov, Aleksandra AU - Demenesku, Jelena AU - Mirkov, Ivana AU - Mileusnić, Dina AU - Petrović, Anja AU - Grigorov, Ilijana AU - Zolotarevski, Lidija AU - Tolinački, Maja AU - Kataranovski, Dragan AU - Brceski, Ilija AU - Kataranovski, Milena PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/801 AB - Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. PB - Elsevier Ireland Ltd, Clare T2 - Toxicology Letters T1 - Toxicity of oral cadmium intake: Impact on gut immunity EP - 99 IS - 2 SP - 89 VL - 237 DO - 10.1016/j.toxlet.2015.06.002 ER -
@article{ author = "Ninkov, Marina and Popov Aleksandrov, Aleksandra and Demenesku, Jelena and Mirkov, Ivana and Mileusnić, Dina and Petrović, Anja and Grigorov, Ilijana and Zolotarevski, Lidija and Tolinački, Maja and Kataranovski, Dragan and Brceski, Ilija and Kataranovski, Milena", year = "2015", abstract = "Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Toxicology Letters", title = "Toxicity of oral cadmium intake: Impact on gut immunity", pages = "99-89", number = "2", volume = "237", doi = "10.1016/j.toxlet.2015.06.002" }
Ninkov, M., Popov Aleksandrov, A., Demenesku, J., Mirkov, I., Mileusnić, D., Petrović, A., Grigorov, I., Zolotarevski, L., Tolinački, M., Kataranovski, D., Brceski, I.,& Kataranovski, M.. (2015). Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters Elsevier Ireland Ltd, Clare., 237(2), 89-99. https://doi.org/10.1016/j.toxlet.2015.06.002
Ninkov M, Popov Aleksandrov A, Demenesku J, Mirkov I, Mileusnić D, Petrović A, Grigorov I, Zolotarevski L, Tolinački M, Kataranovski D, Brceski I, Kataranovski M. Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters. 2015;237(2):89-99. doi:10.1016/j.toxlet.2015.06.002 .
Ninkov, Marina, Popov Aleksandrov, Aleksandra, Demenesku, Jelena, Mirkov, Ivana, Mileusnić, Dina, Petrović, Anja, Grigorov, Ilijana, Zolotarevski, Lidija, Tolinački, Maja, Kataranovski, Dragan, Brceski, Ilija, Kataranovski, Milena, "Toxicity of oral cadmium intake: Impact on gut immunity" in Toxicology Letters, 237, no. 2 (2015):89-99, https://doi.org/10.1016/j.toxlet.2015.06.002 . .