Lessons learned - resolving the enigma of genetic factors in IBS
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2016
Authors
Gazouli, MariaWouters, Mira M.
Kapur-Pojskić, Lejla
Bengtson, May-Bente
Friedman, Eitan
Nikčević, Gordana
Demetriou, Christiana A.
Mulak, Agata
Santos, Javier
Niesler, Beate
Article (Published version)
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Show full item recordAbstract
IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In t...his Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.
Source:
Nature Reviews Gastroenterology & Hepatology, 2016, 13, 2, 77-87Publisher:
- Nature Portfolio, Berlin
Funding / projects:
- COST (COoperation in Science and Technology) programme [BM1106]
Note:
- Peer-reviewed manuscript: https://imagine.imgge.bg.ac.rs/handle/123456789/1625
Related info:
DOI: 10.1038/nrgastro.2015.206
ISSN: 1759-5045
PubMed: 26726033
WoS: 000369313600007
Scopus: 2-s2.0-84956753155
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Gazouli, Maria AU - Wouters, Mira M. AU - Kapur-Pojskić, Lejla AU - Bengtson, May-Bente AU - Friedman, Eitan AU - Nikčević, Gordana AU - Demetriou, Christiana A. AU - Mulak, Agata AU - Santos, Javier AU - Niesler, Beate PY - 2016 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/977 AB - IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future. PB - Nature Portfolio, Berlin T2 - Nature Reviews Gastroenterology & Hepatology T1 - Lessons learned - resolving the enigma of genetic factors in IBS EP - 87 IS - 2 SP - 77 VL - 13 DO - 10.1038/nrgastro.2015.206 ER -
@article{ author = "Gazouli, Maria and Wouters, Mira M. and Kapur-Pojskić, Lejla and Bengtson, May-Bente and Friedman, Eitan and Nikčević, Gordana and Demetriou, Christiana A. and Mulak, Agata and Santos, Javier and Niesler, Beate", year = "2016", abstract = "IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.", publisher = "Nature Portfolio, Berlin", journal = "Nature Reviews Gastroenterology & Hepatology", title = "Lessons learned - resolving the enigma of genetic factors in IBS", pages = "87-77", number = "2", volume = "13", doi = "10.1038/nrgastro.2015.206" }
Gazouli, M., Wouters, M. M., Kapur-Pojskić, L., Bengtson, M., Friedman, E., Nikčević, G., Demetriou, C. A., Mulak, A., Santos, J.,& Niesler, B.. (2016). Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology Nature Portfolio, Berlin., 13(2), 77-87. https://doi.org/10.1038/nrgastro.2015.206
Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson M, Friedman E, Nikčević G, Demetriou CA, Mulak A, Santos J, Niesler B. Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology. 2016;13(2):77-87. doi:10.1038/nrgastro.2015.206 .
Gazouli, Maria, Wouters, Mira M., Kapur-Pojskić, Lejla, Bengtson, May-Bente, Friedman, Eitan, Nikčević, Gordana, Demetriou, Christiana A., Mulak, Agata, Santos, Javier, Niesler, Beate, "Lessons learned - resolving the enigma of genetic factors in IBS" in Nature Reviews Gastroenterology & Hepatology, 13, no. 2 (2016):77-87, https://doi.org/10.1038/nrgastro.2015.206 . .