Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat
Samo za registrovane korisnike
1996
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E(1) (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal.
Ključne reči:
transferrin receptor / ferritin / beta-globin / band 3 protein / b/b rat / alpha-globin / +/b ratIzvor:
Experientia, 1996, 52, 8, 807-811Izdavač:
- Birkhauser Verlag AG
DOI: 10.1007/BF01923994
ISSN: 0014-4754
PubMed: 8774753
WoS: A1996VC25600011
Scopus: 2-s2.0-0029741692
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Savković, S AU - Pavlović, Sonja AU - Mitrović, T AU - Joksimović, M AU - Marjanović, J AU - Glisin, V AU - Popović, Z PY - 1996 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/97 AB - The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E(1) (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal. PB - Birkhauser Verlag AG T2 - Experientia T1 - Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat EP - 811 IS - 8 SP - 807 VL - 52 DO - 10.1007/BF01923994 ER -
@article{ author = "Savković, S and Pavlović, Sonja and Mitrović, T and Joksimović, M and Marjanović, J and Glisin, V and Popović, Z", year = "1996", abstract = "The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E(1) (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal.", publisher = "Birkhauser Verlag AG", journal = "Experientia", title = "Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat", pages = "811-807", number = "8", volume = "52", doi = "10.1007/BF01923994" }
Savković, S., Pavlović, S., Mitrović, T., Joksimović, M., Marjanović, J., Glisin, V.,& Popović, Z.. (1996). Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat. in Experientia Birkhauser Verlag AG., 52(8), 807-811. https://doi.org/10.1007/BF01923994
Savković S, Pavlović S, Mitrović T, Joksimović M, Marjanović J, Glisin V, Popović Z. Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat. in Experientia. 1996;52(8):807-811. doi:10.1007/BF01923994 .
Savković, S, Pavlović, Sonja, Mitrović, T, Joksimović, M, Marjanović, J, Glisin, V, Popović, Z, "Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat" in Experientia, 52, no. 8 (1996):807-811, https://doi.org/10.1007/BF01923994 . .