TY  - CONF
AU  - Karanović, Jelena
AU  - Beraković, Doroteja
AU  - Katrašnik, Mojca
AU  - Pantović-Stefanović, Maja
AU  - Radenković, Lana
AU  - Garai, Nemanja
AU  - Ivković, Maja
AU  - Savić-Pavićević, Dušanka
AU  - Zupanc, Tomaž
AU  - Videtič Paska, Alja
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2197
AB  - Introduction: Suicidal behavior ranges between suicidal ideation and completed suicide. Completed
suicide accounts for over 700,000 deaths worldwide, while attempted suicide is 20 times more frequent.
Genetic background is an important factor contributing to suicidal behavior, and candidate genes linked
to several neurotransmitter systems have been investigated. Alternations in glutamate, γ-aminobutyric
acid (GABA) and polyamine systems have been detected in suicidal behavior. Our aim was to differentiate
genetic predispositions underlying two different types of suicidal behavior, attempted and completed
suicide, in two Balkan populations.
Methods: The study sample included 173 suicide attempters with comorbid psychiatric disorders (major
depressive disorder, bipolar affective disorder, or schizophrenia), 216 non-suicidal psychiatric patients and
172 healthy controls from Serbia, and 333 suicide completers and 356 non-suicidal autopsy controls
from Slovenia. Variants in the genes GRIN2B (rs2268115 and rs220557), GABRG2 (rs424740), and ODC1
(rs1049500 and rs2302614) were genotyped by TaqMan assays and analyzed using PLINK.
Results: The CA genotype of rs220557 in the GRIN2B gene increases the risk for completed suicide
(OR=1.51, p=0.021), and particularly violent suicide (OR=1.49, p=0.037), compared to controls. In the
ODC1 gene, the CA genotype of rs2302614 decreases the risk for completed suicide compared to suicide
attempt (OR=0.32, p=0.012). Marginally, the AC haplotype for variants rs1049500-rs2302614 in the ODC1
gene decreases the risk for completed suicide compared to suicide attempt (OR=0.50, p=0.052).
Conclusion: Specific genetic variants of the glutamate and the polyamine systems are differently distributed
among diverse suicidal phenotypes, thus providing further information on the implication of
these systems in suicidality.
PB  - Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade
C3  - CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia
T1  - Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in suicide attempt and completed suicide In two Balkan populations
EP  - 50
SP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2197
ER  - 

@conference{
author = "Karanović, Jelena and Beraković, Doroteja and Katrašnik, Mojca and Pantović-Stefanović, Maja and Radenković, Lana and Garai, Nemanja and Ivković, Maja and Savić-Pavićević, Dušanka and Zupanc, Tomaž and Videtič Paska, Alja",
year = "2023",
abstract = "Introduction: Suicidal behavior ranges between suicidal ideation and completed suicide. Completed
suicide accounts for over 700,000 deaths worldwide, while attempted suicide is 20 times more frequent.
Genetic background is an important factor contributing to suicidal behavior, and candidate genes linked
to several neurotransmitter systems have been investigated. Alternations in glutamate, γ-aminobutyric
acid (GABA) and polyamine systems have been detected in suicidal behavior. Our aim was to differentiate
genetic predispositions underlying two different types of suicidal behavior, attempted and completed
suicide, in two Balkan populations.
Methods: The study sample included 173 suicide attempters with comorbid psychiatric disorders (major
depressive disorder, bipolar affective disorder, or schizophrenia), 216 non-suicidal psychiatric patients and
172 healthy controls from Serbia, and 333 suicide completers and 356 non-suicidal autopsy controls
from Slovenia. Variants in the genes GRIN2B (rs2268115 and rs220557), GABRG2 (rs424740), and ODC1
(rs1049500 and rs2302614) were genotyped by TaqMan assays and analyzed using PLINK.
Results: The CA genotype of rs220557 in the GRIN2B gene increases the risk for completed suicide
(OR=1.51, p=0.021), and particularly violent suicide (OR=1.49, p=0.037), compared to controls. In the
ODC1 gene, the CA genotype of rs2302614 decreases the risk for completed suicide compared to suicide
attempt (OR=0.32, p=0.012). Marginally, the AC haplotype for variants rs1049500-rs2302614 in the ODC1
gene decreases the risk for completed suicide compared to suicide attempt (OR=0.50, p=0.052).
Conclusion: Specific genetic variants of the glutamate and the polyamine systems are differently distributed
among diverse suicidal phenotypes, thus providing further information on the implication of
these systems in suicidality.",
publisher = "Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade",
journal = "CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia",
title = "Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in suicide attempt and completed suicide In two Balkan populations",
pages = "50-50",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2197"
}

Karanović, J., Beraković, D., Katrašnik, M., Pantović-Stefanović, M., Radenković, L., Garai, N., Ivković, M., Savić-Pavićević, D., Zupanc, T.,& Videtič Paska, A.. (2023). Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in suicide attempt and completed suicide In two Balkan populations. in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia
Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade., 50-50.
https://hdl.handle.net/21.15107/rcub_imagine_2197

Karanović J, Beraković D, Katrašnik M, Pantović-Stefanović M, Radenković L, Garai N, Ivković M, Savić-Pavićević D, Zupanc T, Videtič Paska A. Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in suicide attempt and completed suicide In two Balkan populations. in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia. 2023;:50-50.
https://hdl.handle.net/21.15107/rcub_imagine_2197 .

Karanović, Jelena, Beraković, Doroteja, Katrašnik, Mojca, Pantović-Stefanović, Maja, Radenković, Lana, Garai, Nemanja, Ivković, Maja, Savić-Pavićević, Dušanka, Zupanc, Tomaž, Videtič Paska, Alja, "Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in suicide attempt and completed suicide In two Balkan populations" in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia (2023):50-50,
https://hdl.handle.net/21.15107/rcub_imagine_2197 .