TY  - JOUR
AU  - Zivković, Jelena
AU  - Savikin, Katarina
AU  - Stanisavljević, Nemanja
AU  - Zdunić, Gordana
AU  - Stanojković, Tatjana
AU  - Samardžić, Jelena
PY  - 2018
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1133
AB  - Decoctions obtained from dried apple and pear fruits were subjected to in vitro digestion in the presence of a food matrix in order to determine changes in the polyphenol content and antiproliferative activity. The total phenolic and total proanthocyanidins contents were determined using spectrophotometrical methods, and the phenolic compounds were analyzed by RP-HPLC/DAD before and after digestion. Chlorogenic acid and phlorizin dihydrate were the major identified compounds. The addition of a food matrix immediately decreased the contents of individual and total phenolics. After digestion, they were slightly elevated but still lower than in the initial samples. Antiproliferative activity was investigated on human epithelial carcinoma cell line (HeLa), human colon carcinoma (LS174) and human foetal lung fibroblast (MRC-5) cells. The exhibited growth inhibition was not correlated with the content of phenolics in the tested samples, indicating that it could not be explained solely by their content. With the exception of the apple decoction effect on HeLa cells, the digestion process resulted in significant increases in the antiproliferative activity.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion
EP  - 1326
IS  - 12
SP  - 1315
VL  - 83
DO  - 10.2298/JSC180604073Z
ER  - 

@article{
author = "Zivković, Jelena and Savikin, Katarina and Stanisavljević, Nemanja and Zdunić, Gordana and Stanojković, Tatjana and Samardžić, Jelena",
year = "2018",
abstract = "Decoctions obtained from dried apple and pear fruits were subjected to in vitro digestion in the presence of a food matrix in order to determine changes in the polyphenol content and antiproliferative activity. The total phenolic and total proanthocyanidins contents were determined using spectrophotometrical methods, and the phenolic compounds were analyzed by RP-HPLC/DAD before and after digestion. Chlorogenic acid and phlorizin dihydrate were the major identified compounds. The addition of a food matrix immediately decreased the contents of individual and total phenolics. After digestion, they were slightly elevated but still lower than in the initial samples. Antiproliferative activity was investigated on human epithelial carcinoma cell line (HeLa), human colon carcinoma (LS174) and human foetal lung fibroblast (MRC-5) cells. The exhibited growth inhibition was not correlated with the content of phenolics in the tested samples, indicating that it could not be explained solely by their content. With the exception of the apple decoction effect on HeLa cells, the digestion process resulted in significant increases in the antiproliferative activity.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion",
pages = "1326-1315",
number = "12",
volume = "83",
doi = "10.2298/JSC180604073Z"
}

Zivković, J., Savikin, K., Stanisavljević, N., Zdunić, G., Stanojković, T.,& Samardžić, J.. (2018). Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(12), 1315-1326.
https://doi.org/10.2298/JSC180604073Z

Zivković J, Savikin K, Stanisavljević N, Zdunić G, Stanojković T, Samardžić J. Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion. in Journal of the Serbian Chemical Society. 2018;83(12):1315-1326.
doi:10.2298/JSC180604073Z .

Zivković, Jelena, Savikin, Katarina, Stanisavljević, Nemanja, Zdunić, Gordana, Stanojković, Tatjana, Samardžić, Jelena, "Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion" in Journal of the Serbian Chemical Society, 83, no. 12 (2018):1315-1326,
https://doi.org/10.2298/JSC180604073Z . .