TY  - JOUR
AU  - Zivković, Jelena
AU  - Savikin, Katarina
AU  - Stanisavljević, Nemanja
AU  - Zdunić, Gordana
AU  - Stanojković, Tatjana
AU  - Samardžić, Jelena
PY  - 2018
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1133
AB  - Decoctions obtained from dried apple and pear fruits were subjected to in vitro digestion in the presence of a food matrix in order to determine changes in the polyphenol content and antiproliferative activity. The total phenolic and total proanthocyanidins contents were determined using spectrophotometrical methods, and the phenolic compounds were analyzed by RP-HPLC/DAD before and after digestion. Chlorogenic acid and phlorizin dihydrate were the major identified compounds. The addition of a food matrix immediately decreased the contents of individual and total phenolics. After digestion, they were slightly elevated but still lower than in the initial samples. Antiproliferative activity was investigated on human epithelial carcinoma cell line (HeLa), human colon carcinoma (LS174) and human foetal lung fibroblast (MRC-5) cells. The exhibited growth inhibition was not correlated with the content of phenolics in the tested samples, indicating that it could not be explained solely by their content. With the exception of the apple decoction effect on HeLa cells, the digestion process resulted in significant increases in the antiproliferative activity.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion
EP  - 1326
IS  - 12
SP  - 1315
VL  - 83
DO  - 10.2298/JSC180604073Z
ER  - 

@article{
author = "Zivković, Jelena and Savikin, Katarina and Stanisavljević, Nemanja and Zdunić, Gordana and Stanojković, Tatjana and Samardžić, Jelena",
year = "2018",
abstract = "Decoctions obtained from dried apple and pear fruits were subjected to in vitro digestion in the presence of a food matrix in order to determine changes in the polyphenol content and antiproliferative activity. The total phenolic and total proanthocyanidins contents were determined using spectrophotometrical methods, and the phenolic compounds were analyzed by RP-HPLC/DAD before and after digestion. Chlorogenic acid and phlorizin dihydrate were the major identified compounds. The addition of a food matrix immediately decreased the contents of individual and total phenolics. After digestion, they were slightly elevated but still lower than in the initial samples. Antiproliferative activity was investigated on human epithelial carcinoma cell line (HeLa), human colon carcinoma (LS174) and human foetal lung fibroblast (MRC-5) cells. The exhibited growth inhibition was not correlated with the content of phenolics in the tested samples, indicating that it could not be explained solely by their content. With the exception of the apple decoction effect on HeLa cells, the digestion process resulted in significant increases in the antiproliferative activity.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion",
pages = "1326-1315",
number = "12",
volume = "83",
doi = "10.2298/JSC180604073Z"
}

Zivković, J., Savikin, K., Stanisavljević, N., Zdunić, G., Stanojković, T.,& Samardžić, J.. (2018). Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(12), 1315-1326.
https://doi.org/10.2298/JSC180604073Z

Zivković J, Savikin K, Stanisavljević N, Zdunić G, Stanojković T, Samardžić J. Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion. in Journal of the Serbian Chemical Society. 2018;83(12):1315-1326.
doi:10.2298/JSC180604073Z .

Zivković, Jelena, Savikin, Katarina, Stanisavljević, Nemanja, Zdunić, Gordana, Stanojković, Tatjana, Samardžić, Jelena, "Chemical composition and antiproliferative potential of dried wild apple and pear tea before and after in vitro simulated digestion" in Journal of the Serbian Chemical Society, 83, no. 12 (2018):1315-1326,
https://doi.org/10.2298/JSC180604073Z . .

TY  - JOUR
AU  - Stojković, Dejan S.
AU  - Davidović, Slobodan
AU  - Zivković, Jelena
AU  - Glamoclija, Jasmina
AU  - Cirić, Ana
AU  - Stevanović, Milena
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
PY  - 2013
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/658
AB  - Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Frontiers in Life Science
T1  - Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
EP  - 223
IS  - 3-4
SP  - 218
VL  - 7
DO  - 10.1080/21553769.2014.901925
ER  - 

@article{
author = "Stojković, Dejan S. and Davidović, Slobodan and Zivković, Jelena and Glamoclija, Jasmina and Cirić, Ana and Stevanović, Milena and Ferreira, Isabel C. F. R. and Soković, Marina",
year = "2013",
abstract = "Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Frontiers in Life Science",
title = "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid",
pages = "223-218",
number = "3-4",
volume = "7",
doi = "10.1080/21553769.2014.901925"
}

Stojković, D. S., Davidović, S., Zivković, J., Glamoclija, J., Cirić, A., Stevanović, M., Ferreira, I. C. F. R.,& Soković, M.. (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science
Taylor & Francis Ltd, Abingdon., 7(3-4), 218-223.
https://doi.org/10.1080/21553769.2014.901925

Stojković DS, Davidović S, Zivković J, Glamoclija J, Cirić A, Stevanović M, Ferreira ICFR, Soković M. Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science. 2013;7(3-4):218-223.
doi:10.1080/21553769.2014.901925 .

Stojković, Dejan S., Davidović, Slobodan, Zivković, Jelena, Glamoclija, Jasmina, Cirić, Ana, Stevanović, Milena, Ferreira, Isabel C. F. R., Soković, Marina, "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid" in Frontiers in Life Science, 7, no. 3-4 (2013):218-223,
https://doi.org/10.1080/21553769.2014.901925 . .

TY  - JOUR
AU  - Popović, Visnja
AU  - Zivković, Jelena
AU  - Davidović, Slobodan
AU  - Stevanović, Milena
AU  - Stojković, Dejan
PY  - 2013
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/664
AB  - Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Topics in Medicinal Chemistry
T1  - Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
EP  - 2806
IS  - 21
SP  - 2791
VL  - 13
DO  - 10.2174/15680266113136660198
ER  - 

@article{
author = "Popović, Visnja and Zivković, Jelena and Davidović, Slobodan and Stevanović, Milena and Stojković, Dejan",
year = "2013",
abstract = "Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Topics in Medicinal Chemistry",
title = "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action",
pages = "2806-2791",
number = "21",
volume = "13",
doi = "10.2174/15680266113136660198"
}

Popović, V., Zivković, J., Davidović, S., Stevanović, M.,& Stojković, D.. (2013). Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(21), 2791-2806.
https://doi.org/10.2174/15680266113136660198

Popović V, Zivković J, Davidović S, Stevanović M, Stojković D. Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry. 2013;13(21):2791-2806.
doi:10.2174/15680266113136660198 .

Popović, Visnja, Zivković, Jelena, Davidović, Slobodan, Stevanović, Milena, Stojković, Dejan, "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action" in Current Topics in Medicinal Chemistry, 13, no. 21 (2013):2791-2806,
https://doi.org/10.2174/15680266113136660198 . .