TY  - JOUR
AU  - Milić, Petar
AU  - Rajković, Katarina
AU  - Nikolić, Goran
AU  - Jeremić, Sanja
AU  - Đurašević, Mirjana
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0263876223000618
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1922
AB  - The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.
T2  - Chemical Engineering Research and Design
T2  - Chemical Engineering Research and DesignChemical Engineering Research and Design
T1  - Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology
EP  - 445
SP  - 439
VL  - 191
DO  - 10.1016/j.cherd.2023.01.051
ER  - 

@article{
author = "Milić, Petar and Rajković, Katarina and Nikolić, Goran and Jeremić, Sanja and Đurašević, Mirjana",
year = "2023",
abstract = "The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.",
journal = "Chemical Engineering Research and Design, Chemical Engineering Research and DesignChemical Engineering Research and Design",
title = "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology",
pages = "445-439",
volume = "191",
doi = "10.1016/j.cherd.2023.01.051"
}

Milić, P., Rajković, K., Nikolić, G., Jeremić, S.,& Đurašević, M.. (2023). Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design, 191, 439-445.
https://doi.org/10.1016/j.cherd.2023.01.051

Milić P, Rajković K, Nikolić G, Jeremić S, Đurašević M. Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design. 2023;191:439-445.
doi:10.1016/j.cherd.2023.01.051 .

Milić, Petar, Rajković, Katarina, Nikolić, Goran, Jeremić, Sanja, Đurašević, Mirjana, "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology" in Chemical Engineering Research and Design, 191 (2023):439-445,
https://doi.org/10.1016/j.cherd.2023.01.051 . .

TY  - JOUR
AU  - Milić, Petar
AU  - Rajković, Katarina
AU  - Nikolić, Goran
AU  - Jeremić, Sanja
AU  - Đurašević, Mirjana
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0263876223000618
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1888
AB  - The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.
T2  - Chemical Engineering Research and Design
T2  - Chemical Engineering Research and DesignChemical Engineering Research and Design
T1  - Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology
EP  - 445
SP  - 439
VL  - 191
DO  - 10.1016/j.cherd.2023.01.051
ER  - 

@article{
author = "Milić, Petar and Rajković, Katarina and Nikolić, Goran and Jeremić, Sanja and Đurašević, Mirjana",
year = "2023",
abstract = "The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.",
journal = "Chemical Engineering Research and Design, Chemical Engineering Research and DesignChemical Engineering Research and Design",
title = "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology",
pages = "445-439",
volume = "191",
doi = "10.1016/j.cherd.2023.01.051"
}

Milić, P., Rajković, K., Nikolić, G., Jeremić, S.,& Đurašević, M.. (2023). Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design, 191, 439-445.
https://doi.org/10.1016/j.cherd.2023.01.051

Milić P, Rajković K, Nikolić G, Jeremić S, Đurašević M. Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design. 2023;191:439-445.
doi:10.1016/j.cherd.2023.01.051 .

Milić, Petar, Rajković, Katarina, Nikolić, Goran, Jeremić, Sanja, Đurašević, Mirjana, "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology" in Chemical Engineering Research and Design, 191 (2023):439-445,
https://doi.org/10.1016/j.cherd.2023.01.051 . .

TY  - JOUR
AU  - Rajković, Katarina
AU  - Drobac, Milica
AU  - Milić, Petar
AU  - Vučić, Vesna
AU  - Arsić, Aleksandra
AU  - Perić, Mirjana
AU  - Radunović, Milena
AU  - Jeremić, Sanja
AU  - Arsenijević, Jelena
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1805
AB  - Juglans nigra (Black walnut) is a source of health-promoting
biologically active compounds used in traditional medicine. The investigation of
bioactive compounds in black walnut could lead to its broader application, as
well as application of its by-products. Therefore, this study aimed to characterize
J. nigra nut and green husk based on chemical analysis of their petroleum ether
and ethanol extracts obtained by ultrasonic and reflux extraction methods,
respectively. Different extract fractions were tested for their antimicrobial
activities using Gram-negative bacteria (Escherichia coli, Pseudomonas
aeruginosa), Gram-positive bacteria (Enterococcus faecalis Staphylococcus
aureus) and yeast (reference strain and clinical isolates of Candida albicans).
Ethanol extracts analysis, performed by High Performance Liquid
Chromatography (HPLC), singled out the ellagic acid as the most dominant
compound in nut (55.0 ± 1.3 × 10-3 kg m-3
) and green husk (114.1 ± 0.5× 10-3 kg
m-3
) extracts. Non-polar compounds were evaluated using Gas Chromatography
(GC) analysis of petroleum ether extracts. Juglans nigra nut and green husk
contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid
(C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic
(C18:1n-9), and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids,
linoleic (C18:2n-6), γ-linolenic (C18:3n-6), and α-linolenic (C18:3n-3) acids.
Ethanol extracts of both J. nigra nut and green husk showed antimicrobial
activity against C. albicans which is the most common cause of yeast infections.
AB  - Juglans nigra (црни орах) као извор биолошки активних једињења користе се у
традиционалној медицини. Истраживање биоактивних једињења присутних у црном ораху
довело би до шире примене његових производа. Зато ова студија има за циљ да
окарактерише орашаст плод и зелену љуску Ј. nigra на основу хемијске анализе њихових
петролетарских и етанолних екстраката, добијених ултразвучним и рефлукс методама
екстракције. Антимикробна активност различитих фракција екстракта је тестирана
коришћењем Грам-негативних бактерија (Escherichia coli, Pseudomonas aeruginosa), Грамозитивних бактерија (Enterococcus faecalis Staphylococcus aureus) и квасница (референтни
сој и клинички изолати Candida albicans). Анализа течном хроматографијом високих
перформанси, издвојила је елагинску киселину као најдоминантније једињење у етанолним
екстрактима орашастог плода (55,0 ± 1,3 × 10-3 kg m-3) и зелене љуске (114,1 ± 0,5 × 10-3
g m-3). Неполарна једињења су процењена применом гасне хроматографске анализе
петролетарских екстракта. Орашаст плод и зелена љуска садрже две засићене масне
киселине, палмитинску (C16:0) и стеаринску киселину (C18:0), затим мононезасићене
масне киселине, палмитолеинску (C16:1n-7), олеинску (C18:1n-9), и вакценску киселину
(C18:1n-7), као и полинезасићене масне киселине, линолну (C18:2n-6), γ-линоленску
(C18:3n-6) и α-линоленску (C18: 3n-3) киселину. Етанолни екстракти орашастог плода и
зелене љуске показали су антимикробну активност нa сојевима C. albicans која је најчешћи
узрочник гљивичних инфекција.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk
T1  - Hemijska karakterizacija i antimikrobna aktivnost orašastog ploda i zelene ljuske Juglans nigra l.
T1  - Xемијска карактеризација и антимикробна активност орашастог плода и зелене љуске Juglans nigra l.
DO  - doi.org/10.2298/JSC230210024R
ER  - 

@article{
author = "Rajković, Katarina and Drobac, Milica and Milić, Petar and Vučić, Vesna and Arsić, Aleksandra and Perić, Mirjana and Radunović, Milena and Jeremić, Sanja and Arsenijević, Jelena",
year = "2023",
abstract = "Juglans nigra (Black walnut) is a source of health-promoting
biologically active compounds used in traditional medicine. The investigation of
bioactive compounds in black walnut could lead to its broader application, as
well as application of its by-products. Therefore, this study aimed to characterize
J. nigra nut and green husk based on chemical analysis of their petroleum ether
and ethanol extracts obtained by ultrasonic and reflux extraction methods,
respectively. Different extract fractions were tested for their antimicrobial
activities using Gram-negative bacteria (Escherichia coli, Pseudomonas
aeruginosa), Gram-positive bacteria (Enterococcus faecalis Staphylococcus
aureus) and yeast (reference strain and clinical isolates of Candida albicans).
Ethanol extracts analysis, performed by High Performance Liquid
Chromatography (HPLC), singled out the ellagic acid as the most dominant
compound in nut (55.0 ± 1.3 × 10-3 kg m-3
) and green husk (114.1 ± 0.5× 10-3 kg
m-3
) extracts. Non-polar compounds were evaluated using Gas Chromatography
(GC) analysis of petroleum ether extracts. Juglans nigra nut and green husk
contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid
(C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic
(C18:1n-9), and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids,
linoleic (C18:2n-6), γ-linolenic (C18:3n-6), and α-linolenic (C18:3n-3) acids.
Ethanol extracts of both J. nigra nut and green husk showed antimicrobial
activity against C. albicans which is the most common cause of yeast infections., Juglans nigra (црни орах) као извор биолошки активних једињења користе се у
традиционалној медицини. Истраживање биоактивних једињења присутних у црном ораху
довело би до шире примене његових производа. Зато ова студија има за циљ да
окарактерише орашаст плод и зелену љуску Ј. nigra на основу хемијске анализе њихових
петролетарских и етанолних екстраката, добијених ултразвучним и рефлукс методама
екстракције. Антимикробна активност различитих фракција екстракта је тестирана
коришћењем Грам-негативних бактерија (Escherichia coli, Pseudomonas aeruginosa), Грамозитивних бактерија (Enterococcus faecalis Staphylococcus aureus) и квасница (референтни
сој и клинички изолати Candida albicans). Анализа течном хроматографијом високих
перформанси, издвојила је елагинску киселину као најдоминантније једињење у етанолним
екстрактима орашастог плода (55,0 ± 1,3 × 10-3 kg m-3) и зелене љуске (114,1 ± 0,5 × 10-3
g m-3). Неполарна једињења су процењена применом гасне хроматографске анализе
петролетарских екстракта. Орашаст плод и зелена љуска садрже две засићене масне
киселине, палмитинску (C16:0) и стеаринску киселину (C18:0), затим мононезасићене
масне киселине, палмитолеинску (C16:1n-7), олеинску (C18:1n-9), и вакценску киселину
(C18:1n-7), као и полинезасићене масне киселине, линолну (C18:2n-6), γ-линоленску
(C18:3n-6) и α-линоленску (C18: 3n-3) киселину. Етанолни екстракти орашастог плода и
зелене љуске показали су антимикробну активност нa сојевима C. albicans која је најчешћи
узрочник гљивичних инфекција.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk, Hemijska karakterizacija i antimikrobna aktivnost orašastog ploda i zelene ljuske Juglans nigra l., Xемијска карактеризација и антимикробна активност орашастог плода и зелене љуске Juglans nigra l.",
doi = "doi.org/10.2298/JSC230210024R"
}

Rajković, K., Drobac, M., Milić, P., Vučić, V., Arsić, A., Perić, M., Radunović, M., Jeremić, S.,& Arsenijević, J.. (2023). Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society..
https://doi.org/doi.org/10.2298/JSC230210024R

Rajković K, Drobac M, Milić P, Vučić V, Arsić A, Perić M, Radunović M, Jeremić S, Arsenijević J. Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk. in Journal of the Serbian Chemical Society. 2023;.
doi:doi.org/10.2298/JSC230210024R .

Rajković, Katarina, Drobac, Milica, Milić, Petar, Vučić, Vesna, Arsić, Aleksandra, Perić, Mirjana, Radunović, Milena, Jeremić, Sanja, Arsenijević, Jelena, "Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk" in Journal of the Serbian Chemical Society (2023),
https://doi.org/doi.org/10.2298/JSC230210024R . .

TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Jeremić, Sanja
AU  - Milić, Petar S.
AU  - Kostić, Marina
AU  - Arsić-Arsenijević, Valentina
AU  - Gavrilović, Marijana
AU  - Krstić, Boro
PY  - 2017
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1008
AB  - Ultrasound-assisted extraction (US-AE) of total extractive substances from the herb Lady's Bedstraw (Galium verum L.) is useful extraction method for its application in food manufacturing. The effect of different temperatures (T) and solventto-solid ratios (S) on the US-AE extraction yield was studied in this paper. The influence and optimum of the operating parameters (T and S) was investigated using response surface methodology (RSM). The T and S had impact on extraction yield. RSM showed that the optimal extraction parameters, which gave a maximum extraction yield of 18.7%, were T of 40 oC and S of 30 kg kg(-1). Using modeled optimized conditions, detected relative difference between predicted and experimental yield was 3.3 %. RSM successfully predicted optimal parameters and proved as useful tool for standardization of extraction conditions for bioactive components from plants important for food industry.
PB  - Budapest Univ Technology Economics, Budapest
T2  - Periodica Polytechnica-Chemical Engineering
T1  - Optimization of Ultrasound-Assisted Extraction of Total Extractive Substances from Galium verum L
EP  - 205
IS  - 3
SP  - 200
VL  - 61
DO  - 10.3311/PPch.9580
ER  - 

@article{
author = "Rajković, Katarina M. and Jeremić, Sanja and Milić, Petar S. and Kostić, Marina and Arsić-Arsenijević, Valentina and Gavrilović, Marijana and Krstić, Boro",
year = "2017",
abstract = "Ultrasound-assisted extraction (US-AE) of total extractive substances from the herb Lady's Bedstraw (Galium verum L.) is useful extraction method for its application in food manufacturing. The effect of different temperatures (T) and solventto-solid ratios (S) on the US-AE extraction yield was studied in this paper. The influence and optimum of the operating parameters (T and S) was investigated using response surface methodology (RSM). The T and S had impact on extraction yield. RSM showed that the optimal extraction parameters, which gave a maximum extraction yield of 18.7%, were T of 40 oC and S of 30 kg kg(-1). Using modeled optimized conditions, detected relative difference between predicted and experimental yield was 3.3 %. RSM successfully predicted optimal parameters and proved as useful tool for standardization of extraction conditions for bioactive components from plants important for food industry.",
publisher = "Budapest Univ Technology Economics, Budapest",
journal = "Periodica Polytechnica-Chemical Engineering",
title = "Optimization of Ultrasound-Assisted Extraction of Total Extractive Substances from Galium verum L",
pages = "205-200",
number = "3",
volume = "61",
doi = "10.3311/PPch.9580"
}

Rajković, K. M., Jeremić, S., Milić, P. S., Kostić, M., Arsić-Arsenijević, V., Gavrilović, M.,& Krstić, B.. (2017). Optimization of Ultrasound-Assisted Extraction of Total Extractive Substances from Galium verum L. in Periodica Polytechnica-Chemical Engineering
Budapest Univ Technology Economics, Budapest., 61(3), 200-205.
https://doi.org/10.3311/PPch.9580

Rajković KM, Jeremić S, Milić PS, Kostić M, Arsić-Arsenijević V, Gavrilović M, Krstić B. Optimization of Ultrasound-Assisted Extraction of Total Extractive Substances from Galium verum L. in Periodica Polytechnica-Chemical Engineering. 2017;61(3):200-205.
doi:10.3311/PPch.9580 .

Rajković, Katarina M., Jeremić, Sanja, Milić, Petar S., Kostić, Marina, Arsić-Arsenijević, Valentina, Gavrilović, Marijana, Krstić, Boro, "Optimization of Ultrasound-Assisted Extraction of Total Extractive Substances from Galium verum L" in Periodica Polytechnica-Chemical Engineering, 61, no. 3 (2017):200-205,
https://doi.org/10.3311/PPch.9580 . .