TY  - JOUR
AU  - Jelicić, Jelena
AU  - Todorovic-Balint, Milena
AU  - Perunicić-Jovanović, Maja
AU  - Boricić, Novica
AU  - Micev, Marjan
AU  - Stojsić, Jelena
AU  - Antić, Darko
AU  - Anđelić, Boško
AU  - Bila, Jelena
AU  - Balint, Bela
AU  - Pavlović, Sonja
AU  - Mihaljević, Biljana
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/944
AB  - Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3 % DLBCL patients, 81.8 % primary CNS DLBCL and 92.3 % FL. Absolute lymphocyte count-ALC/Absolute monocyte count-AMC  gt  2.6 in DLBCL and ALC/AMC a parts per thousand yenaEuro parts per thousand 4.7 in FL were associated with better event-free survival (EFS) and overall survival (OS) (p  lt  0.05). In DLBCL, MVD  gt  42 blood vessels/0.36 mm(2) correlated with primary resistant disease (p  lt  0.0001), poorer EFS and OS (p = 0.014). High CD44s expression in FL correlated with inferior EFS and OS (p  lt  0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/AMC was independent parameter that affected OS (HR 3.27, 95 % CI 1.51-7.09, p = 0.003) along with the NCCN-IPI (HR 1.39, 95 % CI 1.08-1.79, p = 0.01). Furthermore, in FL, ALC/AMC mostly influenced OS (HR 5.21, 95 % CI 1.17-23.21, p = 0.03), followed with the FLIPI (HR 3.98, 95 % CI 1.06-14.95, p = 0.041). In DLBCL and FL, ALC/AMC is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify patients with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s).
PB  - Springer, Dordrecht
T2  - Pathology & Oncology Research
T1  - The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas
EP  - 577
IS  - 3
SP  - 567
VL  - 22
DO  - 10.1007/s12253-015-0032-7
ER  - 

@article{
author = "Jelicić, Jelena and Todorovic-Balint, Milena and Perunicić-Jovanović, Maja and Boricić, Novica and Micev, Marjan and Stojsić, Jelena and Antić, Darko and Anđelić, Boško and Bila, Jelena and Balint, Bela and Pavlović, Sonja and Mihaljević, Biljana",
year = "2016",
abstract = "Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3 % DLBCL patients, 81.8 % primary CNS DLBCL and 92.3 % FL. Absolute lymphocyte count-ALC/Absolute monocyte count-AMC  gt  2.6 in DLBCL and ALC/AMC a parts per thousand yenaEuro parts per thousand 4.7 in FL were associated with better event-free survival (EFS) and overall survival (OS) (p  lt  0.05). In DLBCL, MVD  gt  42 blood vessels/0.36 mm(2) correlated with primary resistant disease (p  lt  0.0001), poorer EFS and OS (p = 0.014). High CD44s expression in FL correlated with inferior EFS and OS (p  lt  0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/AMC was independent parameter that affected OS (HR 3.27, 95 % CI 1.51-7.09, p = 0.003) along with the NCCN-IPI (HR 1.39, 95 % CI 1.08-1.79, p = 0.01). Furthermore, in FL, ALC/AMC mostly influenced OS (HR 5.21, 95 % CI 1.17-23.21, p = 0.03), followed with the FLIPI (HR 3.98, 95 % CI 1.06-14.95, p = 0.041). In DLBCL and FL, ALC/AMC is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify patients with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s).",
publisher = "Springer, Dordrecht",
journal = "Pathology & Oncology Research",
title = "The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas",
pages = "577-567",
number = "3",
volume = "22",
doi = "10.1007/s12253-015-0032-7"
}

Jelicić, J., Todorovic-Balint, M., Perunicić-Jovanović, M., Boricić, N., Micev, M., Stojsić, J., Antić, D., Anđelić, B., Bila, J., Balint, B., Pavlović, S.,& Mihaljević, B.. (2016). The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas. in Pathology & Oncology Research
Springer, Dordrecht., 22(3), 567-577.
https://doi.org/10.1007/s12253-015-0032-7

Jelicić J, Todorovic-Balint M, Perunicić-Jovanović M, Boricić N, Micev M, Stojsić J, Antić D, Anđelić B, Bila J, Balint B, Pavlović S, Mihaljević B. The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas. in Pathology & Oncology Research. 2016;22(3):567-577.
doi:10.1007/s12253-015-0032-7 .

Jelicić, Jelena, Todorovic-Balint, Milena, Perunicić-Jovanović, Maja, Boricić, Novica, Micev, Marjan, Stojsić, Jelena, Antić, Darko, Anđelić, Boško, Bila, Jelena, Balint, Bela, Pavlović, Sonja, Mihaljević, Biljana, "The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas" in Pathology & Oncology Research, 22, no. 3 (2016):567-577,
https://doi.org/10.1007/s12253-015-0032-7 . .