TY  - JOUR
AU  - Bogdanović, Aleksandar
AU  - Despotović, Jovana
AU  - Galun, Danijel
AU  - Bidzić, Nemanja
AU  - Nikolić, Aleksandra
AU  - Rosić, Jovana
AU  - Krivokapić, Zoran
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1490
AB  - Purpose: There are limited data on expression of epithelial-mesenchymal transition (EMT) markers in patients with colorectal liver metastases (CRLM). The study aim was to evaluate the expression and prognostic significance of E-cadherin (CDH1), fibronectin (FN1) and vimentin (VIM) in patients with CRLM after curative-intent liver resection. Patients and Methods: Thirty patients with CRLM managed by curative-intent liver resection were included in this prospective pilot study. Blood samples, colorectal liver metastases and surrounding non-tumor liver tissue were collected. Expression of CDH1, FN1 and VIM was analyzed by quantitative real-time polymerase chain reaction. Expression in CRLM and non-tumor liver tissue was compared, while expression in serum was correlated with CRLM expression. One-year recurrence-free survival was compared between patients with low and high CDH1, FN1 and VIM expression. Results: The expression of CDH1 was similar in CRLM and non-tumor liver tissues, while FN1 and VIM expression was significantly lower in metastatic tissue (P=0.003 and pP lt  0.001, respectively). Serum expression of CDH1 and VIM was detected in 66.7% and 93.3% of patients, respectively, while FN1 was not detected in any of the patients. The correlation of CDH1 and VIM expression between CRLM and serum was not statistically significant. Decreased CDH1 expression in CRLM and decreased VIM expression in serum were associated with early recurrence after surgical treatment of CRLM. Conclusion: Lower expression of CDH1 in CRLM and lower serum expression of VIM were found to be associated with early recurrence after liver resection for CRLM.
PB  - Dove Medical Press Ltd, Albany
T2  - Cancer Management and Research
T1  - Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection
EP  - 171
SP  - 163
VL  - 13
DO  - 10.2147/CMAR.S287974
ER  - 

@article{
author = "Bogdanović, Aleksandar and Despotović, Jovana and Galun, Danijel and Bidzić, Nemanja and Nikolić, Aleksandra and Rosić, Jovana and Krivokapić, Zoran",
year = "2021",
abstract = "Purpose: There are limited data on expression of epithelial-mesenchymal transition (EMT) markers in patients with colorectal liver metastases (CRLM). The study aim was to evaluate the expression and prognostic significance of E-cadherin (CDH1), fibronectin (FN1) and vimentin (VIM) in patients with CRLM after curative-intent liver resection. Patients and Methods: Thirty patients with CRLM managed by curative-intent liver resection were included in this prospective pilot study. Blood samples, colorectal liver metastases and surrounding non-tumor liver tissue were collected. Expression of CDH1, FN1 and VIM was analyzed by quantitative real-time polymerase chain reaction. Expression in CRLM and non-tumor liver tissue was compared, while expression in serum was correlated with CRLM expression. One-year recurrence-free survival was compared between patients with low and high CDH1, FN1 and VIM expression. Results: The expression of CDH1 was similar in CRLM and non-tumor liver tissues, while FN1 and VIM expression was significantly lower in metastatic tissue (P=0.003 and pP lt  0.001, respectively). Serum expression of CDH1 and VIM was detected in 66.7% and 93.3% of patients, respectively, while FN1 was not detected in any of the patients. The correlation of CDH1 and VIM expression between CRLM and serum was not statistically significant. Decreased CDH1 expression in CRLM and decreased VIM expression in serum were associated with early recurrence after surgical treatment of CRLM. Conclusion: Lower expression of CDH1 in CRLM and lower serum expression of VIM were found to be associated with early recurrence after liver resection for CRLM.",
publisher = "Dove Medical Press Ltd, Albany",
journal = "Cancer Management and Research",
title = "Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection",
pages = "171-163",
volume = "13",
doi = "10.2147/CMAR.S287974"
}

Bogdanović, A., Despotović, J., Galun, D., Bidzić, N., Nikolić, A., Rosić, J.,& Krivokapić, Z.. (2021). Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection. in Cancer Management and Research
Dove Medical Press Ltd, Albany., 13, 163-171.
https://doi.org/10.2147/CMAR.S287974

Bogdanović A, Despotović J, Galun D, Bidzić N, Nikolić A, Rosić J, Krivokapić Z. Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection. in Cancer Management and Research. 2021;13:163-171.
doi:10.2147/CMAR.S287974 .

Bogdanović, Aleksandar, Despotović, Jovana, Galun, Danijel, Bidzić, Nemanja, Nikolić, Aleksandra, Rosić, Jovana, Krivokapić, Zoran, "Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection" in Cancer Management and Research, 13 (2021):163-171,
https://doi.org/10.2147/CMAR.S287974 . .