TY  - CONF
AU  - Jovanović, I.
AU  - Nikolić, Aleksandra
AU  - Dragičević, Sandra
AU  - Jović, M.
AU  - Janković, R.
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2082
AB  - Background & objectives: Autophagy is a crucial cellular mechanism that coordinates various physiological processes. Many cancers can activate autophagy and make the tumour more aggressive. In this study, we analysed autophagy in ovarian cancers. Methods: We included 122 patients with ovarian cancers. Tissue microarray was made for immunohistochemical analysis of p62, LC3, and Beclin1 expressions. Their expressions were correlated with tumour histology type, differentiation, and stage. The percentage of positive tumour cells was estimated from the total number of tumour cells. Samples with positive cells were stratified into three ranges of positivity: <10%; 10–50%; >50%. Results: There was a strong positive correlation between p62 and LC3 expression, while both markers were in negative correlation with Beclin1. The expression of each analysed marker showed a statistically significant association with tumour histological type, stage, and differentiation (p<0.001). While p62 and LC3 were more prominently expressed in patients with high-grade serous ovarian cancer (HGSOC), Beclin 1 expression was lower in HGSOC and more prominent in other histology types. A higher expression of  p62 and LC3 was observed in later tumour stages, while the oppo- site was observed for Beclin1 expression. Tumour differentiation  positively correlated with p62 and LC3 expression, and negatively with Beclin1 expression.  Conclusion: The expression of p62 and LC3 was more promi- nent in HGSOC in comparison to other histology types, while  Beclin1 expression was more prominent in carcinomas other than in HGSOC. While p62 and LC3 expression was associated with higher tumour stages and tumour grades, the opposite was found for Beclin1. Prominent p62 and LC3 expression in combination with weak Beclin1 expression in HGSOC indicate the potential for application of autophagy inhibitors in patients with this tumour subtype.
PB  - Springer
C3  - Virchows Archiv, 34 th European Congress of Pathology - Abstracts
T1  - Expression of autophagy markers in ovarian cancer
EP  - S256
IS  - Supplement 1
SP  - S256
SP  - E-PS-09-003
VL  - 481
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2082
ER  - 

@conference{
author = "Jovanović, I. and Nikolić, Aleksandra and Dragičević, Sandra and Jović, M. and Janković, R.",
year = "2022",
abstract = "Background & objectives: Autophagy is a crucial cellular mechanism that coordinates various physiological processes. Many cancers can activate autophagy and make the tumour more aggressive. In this study, we analysed autophagy in ovarian cancers. Methods: We included 122 patients with ovarian cancers. Tissue microarray was made for immunohistochemical analysis of p62, LC3, and Beclin1 expressions. Their expressions were correlated with tumour histology type, differentiation, and stage. The percentage of positive tumour cells was estimated from the total number of tumour cells. Samples with positive cells were stratified into three ranges of positivity: <10%; 10–50%; >50%. Results: There was a strong positive correlation between p62 and LC3 expression, while both markers were in negative correlation with Beclin1. The expression of each analysed marker showed a statistically significant association with tumour histological type, stage, and differentiation (p<0.001). While p62 and LC3 were more prominently expressed in patients with high-grade serous ovarian cancer (HGSOC), Beclin 1 expression was lower in HGSOC and more prominent in other histology types. A higher expression of  p62 and LC3 was observed in later tumour stages, while the oppo- site was observed for Beclin1 expression. Tumour differentiation  positively correlated with p62 and LC3 expression, and negatively with Beclin1 expression.  Conclusion: The expression of p62 and LC3 was more promi- nent in HGSOC in comparison to other histology types, while  Beclin1 expression was more prominent in carcinomas other than in HGSOC. While p62 and LC3 expression was associated with higher tumour stages and tumour grades, the opposite was found for Beclin1. Prominent p62 and LC3 expression in combination with weak Beclin1 expression in HGSOC indicate the potential for application of autophagy inhibitors in patients with this tumour subtype.",
publisher = "Springer",
journal = "Virchows Archiv, 34 th European Congress of Pathology - Abstracts",
title = "Expression of autophagy markers in ovarian cancer",
pages = "S256-S256-E-PS-09-003",
number = "Supplement 1",
volume = "481",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2082"
}

Jovanović, I., Nikolić, A., Dragičević, S., Jović, M.,& Janković, R.. (2022). Expression of autophagy markers in ovarian cancer. in Virchows Archiv, 34 th European Congress of Pathology - Abstracts
Springer., 481(Supplement 1), S256-S256.
https://hdl.handle.net/21.15107/rcub_imagine_2082

Jovanović I, Nikolić A, Dragičević S, Jović M, Janković R. Expression of autophagy markers in ovarian cancer. in Virchows Archiv, 34 th European Congress of Pathology - Abstracts. 2022;481(Supplement 1):S256-S256.
https://hdl.handle.net/21.15107/rcub_imagine_2082 .

Jovanović, I., Nikolić, Aleksandra, Dragičević, Sandra, Jović, M., Janković, R., "Expression of autophagy markers in ovarian cancer" in Virchows Archiv, 34 th European Congress of Pathology - Abstracts, 481, no. Supplement 1 (2022):S256-S256,
https://hdl.handle.net/21.15107/rcub_imagine_2082 .