TY  - JOUR
AU  - Jovanović, Emilija
AU  - Babić, Tamara
AU  - Dragičević, Sandra
AU  - Kmezic, Stefan
AU  - Nikolić, Aleksandra
PY  - 2023
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.3890
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2223
AB  - The role of tetraspanin CD81 in malignant transformation is best studied in colorectal cancer, and it appears that other transcripts beside the fully coding mRNA may also be dysregulated in malignant cells. Recent data from a comprehensive pan-cancer transcriptome analysis demonstrated differential activity of two alternative CD81 gene promoters in malignant versus nonmalignant gut mucosa. The promoter active in gut mucosa gives rise to transcripts CD81-203 and CD81-213, while the promoter active in colon and rectal cancer gives rise to transcripts CD81-205 and CD81-215. Our study aimed to explore the biomarker potential of the transcripts from the alternative CD81 gene promoters in colon cancer, as well as to investigate their structure and potential function using in silico tools. The analysis of the transcripts' expression in several colon cell lines cultivated in 2D and 3D and a set of colon cancer and healthy gut mucosa samples by qPCR and RNA sequencing suggested their low expression and stromal origin. Expression patterns in tumor and nontumor tissue along with in silico data suppose that the transcript CD81-215 may be a noncoding RNA of stromal origin with possible involvement in signaling related to malignant transformation.
T2  - Cell Biochemistry and Function
T1  - Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer
IS  - n/a
VL  - n/a
DO  - 10.1002/cbf.3890
ER  - 

@article{
author = "Jovanović, Emilija and Babić, Tamara and Dragičević, Sandra and Kmezic, Stefan and Nikolić, Aleksandra",
year = "2023",
abstract = "The role of tetraspanin CD81 in malignant transformation is best studied in colorectal cancer, and it appears that other transcripts beside the fully coding mRNA may also be dysregulated in malignant cells. Recent data from a comprehensive pan-cancer transcriptome analysis demonstrated differential activity of two alternative CD81 gene promoters in malignant versus nonmalignant gut mucosa. The promoter active in gut mucosa gives rise to transcripts CD81-203 and CD81-213, while the promoter active in colon and rectal cancer gives rise to transcripts CD81-205 and CD81-215. Our study aimed to explore the biomarker potential of the transcripts from the alternative CD81 gene promoters in colon cancer, as well as to investigate their structure and potential function using in silico tools. The analysis of the transcripts' expression in several colon cell lines cultivated in 2D and 3D and a set of colon cancer and healthy gut mucosa samples by qPCR and RNA sequencing suggested their low expression and stromal origin. Expression patterns in tumor and nontumor tissue along with in silico data suppose that the transcript CD81-215 may be a noncoding RNA of stromal origin with possible involvement in signaling related to malignant transformation.",
journal = "Cell Biochemistry and Function",
title = "Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer",
number = "n/a",
volume = "n/a",
doi = "10.1002/cbf.3890"
}

Jovanović, E., Babić, T., Dragičević, S., Kmezic, S.,& Nikolić, A.. (2023). Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer. in Cell Biochemistry and Function, n/a(n/a).
https://doi.org/10.1002/cbf.3890

Jovanović E, Babić T, Dragičević S, Kmezic S, Nikolić A. Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer. in Cell Biochemistry and Function. 2023;n/a(n/a).
doi:10.1002/cbf.3890 .

Jovanović, Emilija, Babić, Tamara, Dragičević, Sandra, Kmezic, Stefan, Nikolić, Aleksandra, "Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer" in Cell Biochemistry and Function, n/a, no. n/a (2023),
https://doi.org/10.1002/cbf.3890 . .