TY  - CONF
AU  - Erić, Katarina
AU  - Miladinov, Marko
AU  - Dragičević, Sandra
AU  - Rosić, Jovana
AU  - Barišić, Goran
AU  - Marković, Velimir
AU  - Zeljić, Katarina
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2099
AB  - Patients with locally advanced rectal cancer are mainly treated with chemoradiotherapy (CRT) before
surgery. Less than 20% of patients respond completely to neoadjuvant CRT. To avoid unnecessary treatment, biomarkers
are being sought to identi fy pati ents with rectal cancer who do not respond to therapy. The HOX Transcript Anti sense
Intergenic RNA (HOTAIR) is a long non-coding trans-acti ng RNA molecule that is frequently deregulated in cancers of
the digestive tract and plays a role in chemoresistance. The aim of this study was to investigate HOTAIR as a potential
biomarker for predicting treatment response in patients with rectal cancer.
PB  - Belgrade :  Serbian Association on for Cancer Research
C3  - 6th Congress of the Serbian Association for Cancer Research (SDIR)
T1  - Expression of long non-coding RNA HOTAIR in rectal cancer as a potential predictor of response to chemoradiotherapy
EP  - 82
IS  - 1
SP  - 82
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2099
ER  - 

@conference{
author = "Erić, Katarina and Miladinov, Marko and Dragičević, Sandra and Rosić, Jovana and Barišić, Goran and Marković, Velimir and Zeljić, Katarina",
year = "2023",
abstract = "Patients with locally advanced rectal cancer are mainly treated with chemoradiotherapy (CRT) before
surgery. Less than 20% of patients respond completely to neoadjuvant CRT. To avoid unnecessary treatment, biomarkers
are being sought to identi fy pati ents with rectal cancer who do not respond to therapy. The HOX Transcript Anti sense
Intergenic RNA (HOTAIR) is a long non-coding trans-acti ng RNA molecule that is frequently deregulated in cancers of
the digestive tract and plays a role in chemoresistance. The aim of this study was to investigate HOTAIR as a potential
biomarker for predicting treatment response in patients with rectal cancer.",
publisher = "Belgrade :  Serbian Association on for Cancer Research",
journal = "6th Congress of the Serbian Association for Cancer Research (SDIR)",
title = "Expression of long non-coding RNA HOTAIR in rectal cancer as a potential predictor of response to chemoradiotherapy",
pages = "82-82",
number = "1",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2099"
}

Erić, K., Miladinov, M., Dragičević, S., Rosić, J., Barišić, G., Marković, V.,& Zeljić, K.. (2023). Expression of long non-coding RNA HOTAIR in rectal cancer as a potential predictor of response to chemoradiotherapy. in 6th Congress of the Serbian Association for Cancer Research (SDIR)
Belgrade :  Serbian Association on for Cancer Research.(1), 82-82.
https://hdl.handle.net/21.15107/rcub_imagine_2099

Erić K, Miladinov M, Dragičević S, Rosić J, Barišić G, Marković V, Zeljić K. Expression of long non-coding RNA HOTAIR in rectal cancer as a potential predictor of response to chemoradiotherapy. in 6th Congress of the Serbian Association for Cancer Research (SDIR). 2023;(1):82-82.
https://hdl.handle.net/21.15107/rcub_imagine_2099 .

Erić, Katarina, Miladinov, Marko, Dragičević, Sandra, Rosić, Jovana, Barišić, Goran, Marković, Velimir, Zeljić, Katarina, "Expression of long non-coding RNA HOTAIR in rectal cancer as a potential predictor of response to chemoradiotherapy" in 6th Congress of the Serbian Association for Cancer Research (SDIR), no. 1 (2023):82-82,
https://hdl.handle.net/21.15107/rcub_imagine_2099 .

TY  - JOUR
AU  - Rosić, Jovana
AU  - Miladinov, Marko
AU  - Dragičević, Sandra
AU  - Erić, Katarina
AU  - Bogdanović, Aleksandar
AU  - Krivokapić, Zoran
AU  - Nikolić, Aleksandra
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1769
AB  - Considering the impact of SMAD7 deregulation in colorectal cancer (CRC) progression and the
significance of single nucleotide variant (SNV)-mediated disruptions of microRNA (miRNA)-dependent regulation
for cancer susceptibility, our study aimed to analyze genetic variation in the SMAD7 3′ untranslated region (
3′UTR) in CRC, measure differences in allelic mRNA expression, and evaluate its interference with miRNAmediated
post-transcriptional regulation.
Patients and Methods: This study included 80 patients with different CRC stages and six human colon cancer cell
lines of various histological origins. SMAD7 3′ UTR was analyzed by direct sequencing, followed by the relative
quantification of differential allelic expression of detected variants by allele-specific qRT-PCR. In silico tools were
employed for predictions of regulatory consequences of detected variants.
Results: A total of four different SNVs in one cell line and nine patients were found, among which were a novel
somatic point variant and three already known germline variants (rs16950113, rs1050799536, and
rs1043778717). All evaluated SNVs exhibited variable extents of allelic imbalance in expression. In silico analysis
predicted significant effects of SNVs on miRNA binding efficiency, with each SNV disrupting existing and
creating new target sites for one or more miRNAs.
Conclusion: Imbalance observed in the expression of SNV alleles altering miRNA binding suggests that all
investigated SNVs are potential contributing factors impacting SMAD7 expression regulation in CRC that further
studies should investigate.
PB  - Elsevier
T2  - Gene
T1  - Genetic analysis and allele-specific expression of SMAD7 3′UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance
SP  - 147217
VL  - 859
DO  - doi.org/10.1016/j.gene.2023.147217
ER  - 

@article{
author = "Rosić, Jovana and Miladinov, Marko and Dragičević, Sandra and Erić, Katarina and Bogdanović, Aleksandar and Krivokapić, Zoran and Nikolić, Aleksandra",
year = "2023",
abstract = "Considering the impact of SMAD7 deregulation in colorectal cancer (CRC) progression and the
significance of single nucleotide variant (SNV)-mediated disruptions of microRNA (miRNA)-dependent regulation
for cancer susceptibility, our study aimed to analyze genetic variation in the SMAD7 3′ untranslated region (
3′UTR) in CRC, measure differences in allelic mRNA expression, and evaluate its interference with miRNAmediated
post-transcriptional regulation.
Patients and Methods: This study included 80 patients with different CRC stages and six human colon cancer cell
lines of various histological origins. SMAD7 3′ UTR was analyzed by direct sequencing, followed by the relative
quantification of differential allelic expression of detected variants by allele-specific qRT-PCR. In silico tools were
employed for predictions of regulatory consequences of detected variants.
Results: A total of four different SNVs in one cell line and nine patients were found, among which were a novel
somatic point variant and three already known germline variants (rs16950113, rs1050799536, and
rs1043778717). All evaluated SNVs exhibited variable extents of allelic imbalance in expression. In silico analysis
predicted significant effects of SNVs on miRNA binding efficiency, with each SNV disrupting existing and
creating new target sites for one or more miRNAs.
Conclusion: Imbalance observed in the expression of SNV alleles altering miRNA binding suggests that all
investigated SNVs are potential contributing factors impacting SMAD7 expression regulation in CRC that further
studies should investigate.",
publisher = "Elsevier",
journal = "Gene",
title = "Genetic analysis and allele-specific expression of SMAD7 3′UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance",
pages = "147217",
volume = "859",
doi = "doi.org/10.1016/j.gene.2023.147217"
}

Rosić, J., Miladinov, M., Dragičević, S., Erić, K., Bogdanović, A., Krivokapić, Z.,& Nikolić, A.. (2023). Genetic analysis and allele-specific expression of SMAD7 3′UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance. in Gene
Elsevier., 859, 147217.
https://doi.org/doi.org/10.1016/j.gene.2023.147217

Rosić J, Miladinov M, Dragičević S, Erić K, Bogdanović A, Krivokapić Z, Nikolić A. Genetic analysis and allele-specific expression of SMAD7 3′UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance. in Gene. 2023;859:147217.
doi:doi.org/10.1016/j.gene.2023.147217 .

Rosić, Jovana, Miladinov, Marko, Dragičević, Sandra, Erić, Katarina, Bogdanović, Aleksandar, Krivokapić, Zoran, Nikolić, Aleksandra, "Genetic analysis and allele-specific expression of SMAD7 3′UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance" in Gene, 859 (2023):147217,
https://doi.org/doi.org/10.1016/j.gene.2023.147217 . .

TY  - CONF
AU  - Davidović, Slobodan
AU  - Stanković, Milica
AU  - Erić, Pavle
AU  - Erić, Katarina
PY  - 2023
UR  - https://belbi.bg.ac.rs/
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2019
AB  - White-tailed eagle is the biggest bird of prey in Central and Southeast Europe. In Serbia
it inhabits the Vojvodina province and the valleys of Danube, Sava, Tisa and Tamiš.
Anthropogenic pressure on its habitats in Europe caused a decline in its numbers, but
due to the strict laws protecting both species and its habitats, birds’ numbers are now
steady and increasing. In Serbia, as a strictly protected species it is a subject of different
conservation programs. The available genetic data for this population are scarce and it
is necessary to assess its genetic diversity to improve the existing conservation efforts.
ND1 and Cytb mitochondrial genes can be used to estimate the populations’ adaptation to
different environmental conditions and their variability can potentially be used to evaluate
differentiation between populations.
To assess the genetic diversity of White-tailed eagle in Serbia we used mitochondrial ND1
and Cytb nucleotide sequences from 40 unrelated birds collected in nests. ND1 and Cytb
nucleotide sequences variability was evaluated using standard parameters of genetic
diversity (PGD). Acquired values were compared with the available data for the variability
of the D-loop region which showed that combined ND1/Cytb nucleotide sequences PGD
provide comparable results. Using publicly available sequences we reconstructed haplotype
networks for ND1, Cytb, ND1/Cytb and D-loop which further showed the applicability of ND1/
Cytb in population genetics analyses. Phylogeny reconstructed using combined ND1/Cytb
sequences identified two branches in Serbian white-tailed eagles. Although the majority of
substitutions were nonsynonymous, no selective pressure was detected.
Our data suggest that combined ND1/Cytb sequence variability provides sufficient
information to be used for population comparison, population differentiation analyses
and phylogeny reconstruction, but also gives a tool to potentially identify adaptations to
different environmental conditions.
PB  - Belgrade : Institute of molecular genetics and genetic engineering
C3  - 4th Belgrade Bioinformatics Conference
T1  - Evaluating ND1 and Cytb mitochondrial genes as markers for diversity analysis of protected White-tailed eagle species from Serbia
EP  - 79
SP  - 79
VL  - 4
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2019
ER  - 

@conference{
author = "Davidović, Slobodan and Stanković, Milica and Erić, Pavle and Erić, Katarina",
year = "2023",
abstract = "White-tailed eagle is the biggest bird of prey in Central and Southeast Europe. In Serbia
it inhabits the Vojvodina province and the valleys of Danube, Sava, Tisa and Tamiš.
Anthropogenic pressure on its habitats in Europe caused a decline in its numbers, but
due to the strict laws protecting both species and its habitats, birds’ numbers are now
steady and increasing. In Serbia, as a strictly protected species it is a subject of different
conservation programs. The available genetic data for this population are scarce and it
is necessary to assess its genetic diversity to improve the existing conservation efforts.
ND1 and Cytb mitochondrial genes can be used to estimate the populations’ adaptation to
different environmental conditions and their variability can potentially be used to evaluate
differentiation between populations.
To assess the genetic diversity of White-tailed eagle in Serbia we used mitochondrial ND1
and Cytb nucleotide sequences from 40 unrelated birds collected in nests. ND1 and Cytb
nucleotide sequences variability was evaluated using standard parameters of genetic
diversity (PGD). Acquired values were compared with the available data for the variability
of the D-loop region which showed that combined ND1/Cytb nucleotide sequences PGD
provide comparable results. Using publicly available sequences we reconstructed haplotype
networks for ND1, Cytb, ND1/Cytb and D-loop which further showed the applicability of ND1/
Cytb in population genetics analyses. Phylogeny reconstructed using combined ND1/Cytb
sequences identified two branches in Serbian white-tailed eagles. Although the majority of
substitutions were nonsynonymous, no selective pressure was detected.
Our data suggest that combined ND1/Cytb sequence variability provides sufficient
information to be used for population comparison, population differentiation analyses
and phylogeny reconstruction, but also gives a tool to potentially identify adaptations to
different environmental conditions.",
publisher = "Belgrade : Institute of molecular genetics and genetic engineering",
journal = "4th Belgrade Bioinformatics Conference",
title = "Evaluating ND1 and Cytb mitochondrial genes as markers for diversity analysis of protected White-tailed eagle species from Serbia",
pages = "79-79",
volume = "4",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2019"
}

Davidović, S., Stanković, M., Erić, P.,& Erić, K.. (2023). Evaluating ND1 and Cytb mitochondrial genes as markers for diversity analysis of protected White-tailed eagle species from Serbia. in 4th Belgrade Bioinformatics Conference
Belgrade : Institute of molecular genetics and genetic engineering., 4, 79-79.
https://hdl.handle.net/21.15107/rcub_imagine_2019

Davidović S, Stanković M, Erić P, Erić K. Evaluating ND1 and Cytb mitochondrial genes as markers for diversity analysis of protected White-tailed eagle species from Serbia. in 4th Belgrade Bioinformatics Conference. 2023;4:79-79.
https://hdl.handle.net/21.15107/rcub_imagine_2019 .

Davidović, Slobodan, Stanković, Milica, Erić, Pavle, Erić, Katarina, "Evaluating ND1 and Cytb mitochondrial genes as markers for diversity analysis of protected White-tailed eagle species from Serbia" in 4th Belgrade Bioinformatics Conference, 4 (2023):79-79,
https://hdl.handle.net/21.15107/rcub_imagine_2019 .