TY  - JOUR
AU  - Kwakowsky, Andrea
AU  - Schwirtlich, Marija
AU  - Zhang, Qi
AU  - Eisenstat, David D.
AU  - Erdelyi, Ferenc
AU  - Baranyi, Maria
AU  - Katarova, Zoya D.
AU  - Szabo, Gabor
PY  - 2007
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/279
AB  - Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid.. decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages.
PB  - Wiley-Liss, Hoboken
T2  - Developmental Dynamics
T1  - GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5
EP  - 3544
IS  - 12
SP  - 3532
VL  - 236
DO  - 10.1002/dvdy.21361
ER  - 

@article{
author = "Kwakowsky, Andrea and Schwirtlich, Marija and Zhang, Qi and Eisenstat, David D. and Erdelyi, Ferenc and Baranyi, Maria and Katarova, Zoya D. and Szabo, Gabor",
year = "2007",
abstract = "Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid.. decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages.",
publisher = "Wiley-Liss, Hoboken",
journal = "Developmental Dynamics",
title = "GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5",
pages = "3544-3532",
number = "12",
volume = "236",
doi = "10.1002/dvdy.21361"
}

Kwakowsky, A., Schwirtlich, M., Zhang, Q., Eisenstat, D. D., Erdelyi, F., Baranyi, M., Katarova, Z. D.,& Szabo, G.. (2007). GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5. in Developmental Dynamics
Wiley-Liss, Hoboken., 236(12), 3532-3544.
https://doi.org/10.1002/dvdy.21361

Kwakowsky A, Schwirtlich M, Zhang Q, Eisenstat DD, Erdelyi F, Baranyi M, Katarova ZD, Szabo G. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5. in Developmental Dynamics. 2007;236(12):3532-3544.
doi:10.1002/dvdy.21361 .

Kwakowsky, Andrea, Schwirtlich, Marija, Zhang, Qi, Eisenstat, David D., Erdelyi, Ferenc, Baranyi, Maria, Katarova, Zoya D., Szabo, Gabor, "GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5" in Developmental Dynamics, 236, no. 12 (2007):3532-3544,
https://doi.org/10.1002/dvdy.21361 . .