TY  - JOUR
AU  - Vukotić, Goran
AU  - Matić, Ivana
AU  - Begović, Jelena
AU  - Besu, Irina
AU  - Kojić, Milan
AU  - Đokić, Jelena
AU  - Juranić, Zorica
AU  - Strahinić, Ivana
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/928
AB  - The level of humoral immunoreactivity to total cows' milk proteins (TCMP) in sera of patients suffering from recurrent oral ulcerations, gastrointestinal diseases or haematological malignancies was investigated. TCMP were also hydrolysed with two different species of lactobacilli and dramatic changes in the levels of specific IgG and IgE were found with statistically significant decreases in the levels of specific antibodies in sera from all patient groups. The levels below cut-off values of IgG specific for TCMP hydrolysates were detected in sera from all patients, while values of IgE for hydrolysates obtained with Lactobacillus helveticus BGRA43 and Lactobacillus zeae LMG17315were below cut-off in 85% and 97% of patients, respectively. Competitive ELISA confirmed the specificity of antibodies for immunogenic TCMP epitopes, demonstrating that lactobacilli hydrolyse TCMP by degrading immunogenic epitopes, and could therefore be used in processing of milk proteins to obtain products suitable for patients with altered immune response on TCMP.
PB  - Elsevier Sci Ltd, Oxford
T2  - International Dairy Journal
T1  - Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases
EP  - 7
SP  - 1
VL  - 63
DO  - 10.1016/j.idairyj.2016.07.009
ER  - 

@article{
author = "Vukotić, Goran and Matić, Ivana and Begović, Jelena and Besu, Irina and Kojić, Milan and Đokić, Jelena and Juranić, Zorica and Strahinić, Ivana",
year = "2016",
abstract = "The level of humoral immunoreactivity to total cows' milk proteins (TCMP) in sera of patients suffering from recurrent oral ulcerations, gastrointestinal diseases or haematological malignancies was investigated. TCMP were also hydrolysed with two different species of lactobacilli and dramatic changes in the levels of specific IgG and IgE were found with statistically significant decreases in the levels of specific antibodies in sera from all patient groups. The levels below cut-off values of IgG specific for TCMP hydrolysates were detected in sera from all patients, while values of IgE for hydrolysates obtained with Lactobacillus helveticus BGRA43 and Lactobacillus zeae LMG17315were below cut-off in 85% and 97% of patients, respectively. Competitive ELISA confirmed the specificity of antibodies for immunogenic TCMP epitopes, demonstrating that lactobacilli hydrolyse TCMP by degrading immunogenic epitopes, and could therefore be used in processing of milk proteins to obtain products suitable for patients with altered immune response on TCMP.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "International Dairy Journal",
title = "Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases",
pages = "7-1",
volume = "63",
doi = "10.1016/j.idairyj.2016.07.009"
}

Vukotić, G., Matić, I., Begović, J., Besu, I., Kojić, M., Đokić, J., Juranić, Z.,& Strahinić, I.. (2016). Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases. in International Dairy Journal
Elsevier Sci Ltd, Oxford., 63, 1-7.
https://doi.org/10.1016/j.idairyj.2016.07.009

Vukotić G, Matić I, Begović J, Besu I, Kojić M, Đokić J, Juranić Z, Strahinić I. Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases. in International Dairy Journal. 2016;63:1-7.
doi:10.1016/j.idairyj.2016.07.009 .

Vukotić, Goran, Matić, Ivana, Begović, Jelena, Besu, Irina, Kojić, Milan, Đokić, Jelena, Juranić, Zorica, Strahinić, Ivana, "Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases" in International Dairy Journal, 63 (2016):1-7,
https://doi.org/10.1016/j.idairyj.2016.07.009 . .