Mitić, Gorana P.

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  • Mitić, Gorana P. (1)
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Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis

Vucković, Biljana A.; Đerić, Mirjana J.; Tomić, Branko; Đorđević, Valentina; Bajkin, Branislav V.; Mitić, Gorana P.

(Lippincott Williams & Wilkins, Philadelphia, 2018) 

TY  - JOUR
AU  - Vucković, Biljana A.
AU  - Đerić, Mirjana J.
AU  - Tomić, Branko
AU  - Đorđević, Valentina
AU  - Bajkin, Branislav V.
AU  - Mitić, Gorana P.
PY  - 2018
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1177
AB  - Objective of our study is to determine whether decreased fibrinolytic activity or plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism influence the risk of venous thrombosis. Our case-control study included 100 patients with venous thrombosis, and 100 random controls. When patients were compared with random controls, unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Decreased fibrinolytic activity yielded a 2.7-fold increase in risk for venous thrombosis than physiological fibrinolytic activity (OR 2.70; 95% CI 1.22-5.98), when comparing patients with random controls. Adjustment for several putative confounders did not change the estimate (OR 3.02; 95% CI 1.26-7.22). Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20). Decreased fibrinolytic activity increased, whereas PAI-1 4G/5G polymorphism did not influence venous thrombosis risk in this study.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Blood Coagulation & Fibrinolysis
T1  - Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis
EP  - 24
IS  - 1
SP  - 19
VL  - 29
DO  - 10.1097/MBC.0000000000000656
ER  - 
@article{
author = "Vucković, Biljana A. and Đerić, Mirjana J. and Tomić, Branko and Đorđević, Valentina and Bajkin, Branislav V. and Mitić, Gorana P.",
year = "2018",
abstract = "Objective of our study is to determine whether decreased fibrinolytic activity or plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism influence the risk of venous thrombosis. Our case-control study included 100 patients with venous thrombosis, and 100 random controls. When patients were compared with random controls, unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Decreased fibrinolytic activity yielded a 2.7-fold increase in risk for venous thrombosis than physiological fibrinolytic activity (OR 2.70; 95% CI 1.22-5.98), when comparing patients with random controls. Adjustment for several putative confounders did not change the estimate (OR 3.02; 95% CI 1.26-7.22). Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20). Decreased fibrinolytic activity increased, whereas PAI-1 4G/5G polymorphism did not influence venous thrombosis risk in this study.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Blood Coagulation & Fibrinolysis",
title = "Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis",
pages = "24-19",
number = "1",
volume = "29",
doi = "10.1097/MBC.0000000000000656"
}
Vucković, B. A., Đerić, M. J., Tomić, B., Đorđević, V., Bajkin, B. V.,& Mitić, G. P.. (2018). Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis. in Blood Coagulation & Fibrinolysis
Lippincott Williams & Wilkins, Philadelphia., 29(1), 19-24.
https://doi.org/10.1097/MBC.0000000000000656
Vucković BA, Đerić MJ, Tomić B, Đorđević V, Bajkin BV, Mitić GP. Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis. in Blood Coagulation & Fibrinolysis. 2018;29(1):19-24.
doi:10.1097/MBC.0000000000000656 .
Vucković, Biljana A., Đerić, Mirjana J., Tomić, Branko, Đorđević, Valentina, Bajkin, Branislav V., Mitić, Gorana P., "Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis" in Blood Coagulation & Fibrinolysis, 29, no. 1 (2018):19-24,
https://doi.org/10.1097/MBC.0000000000000656 . .
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